Correction to: Birch Bark Extract: A Review in Epidermolysis Bullosa
(Source: Drugs)
Source: Drugs - September 21, 2023 Category: Drugs & Pharmacology Source Type: research
C-type lectin receptor expression is a hallmark of neutrophils infiltrating the skin in epidermolysis bullosa acquisita
DiscussionCollectively, our results suggest that while the upregulation of Clec4n, Clec4d, and Clec4e is a hallmark of activated dermal neutrophil populations, their individual contribution to the pathogenesis of EBA is dispensable. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - September 20, 2023 Category: Allergy & Immunology Source Type: research
Inflammation-mediated fibroblast activation and immune dysregulation in collagen VII-deficient skin
Inflammation is known to play a critical role in all stages of tumorigenesis; however, less is known about how it predisposes the tissue microenvironment preceding tumor formation. Recessive dystrophic epidermolysis bullosa (RDEB), a skin-blistering disease secondary to COL7A1 mutations and associated with chronic wounding, inflammation, fibrosis, and cutaneous squamous cell carcinoma (cSCC), models this dynamic. Here, we used single-cell RNA sequencing (scRNAseq) to analyze gene expression patterns in skin cells from a mouse model of RDEB. We uncovered a complex landscape within the RDEB dermal microenvironment that exhib...
Source: Frontiers in Immunology - September 20, 2023 Category: Allergy & Immunology Source Type: research
Infrahyoid flap ‐ a good substitute of free flaps for oral reconstruction during COVID‐19 pandemic
ConclusionsInfrahyoid flap is a viable alternative to free flap for repairing medium-sized oral defects in compromised patients and during COVID-19 pandemic.This article is protected by copyright. All rights reserved. (Source: Surgical Practice)
Source: Surgical Practice - September 19, 2023 Category: Surgery Authors: Tam ‐Lin Chow,
Siu‐Chung Fung,
Calvin K. P. Tsui,
Jeren Jin Mun Lim Tags: ORIGINAL ARTICLE Source Type: research
(New) antenatal ultrasound signs of fetal junctional epidermolysis bullosa: A case report and systematic review of literature
We describe a marked perioral hipoecogenicity as a novel sign of skin-mucous denudation, which could be helpful for future diagnosis. A review of literature, focused specifically on the antenatal sonography role, is also reported. Prenatal ultrasound-based diagnosis of epidermolysis bullosa is difficult, especially in apparently low risk contexts, but may be possible.PMID:37717401 | DOI:10.1016/j.ejogrb.2023.08.379 (Source: Reproductive Biology)
Source: Reproductive Biology - September 17, 2023 Category: Reproduction Medicine Authors: Valentina Tosto Beatriz Herrero Tamara Illescas Maria De la Calle Fernandez-Miranda Barbara Moreno-Sanz Raul de Lucas Jos è Luis Bartha Eugenia Antolin Source Type: research
(New) antenatal ultrasound signs of fetal junctional epidermolysis bullosa: A case report and systematic review of literature
We describe a marked perioral hipoecogenicity as a novel sign of skin-mucous denudation, which could be helpful for future diagnosis. A review of literature, focused specifically on the antenatal sonography role, is also reported. Prenatal ultrasound-based diagnosis of epidermolysis bullosa is difficult, especially in apparently low risk contexts, but may be possible.PMID:37717401 | DOI:10.1016/j.ejogrb.2023.08.379 (Source: Reproductive Biology)
Source: Reproductive Biology - September 17, 2023 Category: Reproduction Medicine Authors: Valentina Tosto Beatriz Herrero Tamara Illescas Maria De la Calle Fernandez-Miranda Barbara Moreno-Sanz Raul de Lucas Jos è Luis Bartha Eugenia Antolin Source Type: research
PRIMA-1MET/APR-246 can partially rescue in vitro cell adhesion of patient-derived junctional epidermolysis bullosa epidermal cells.
The epithelial transcription factor tumor protein 63, p63, is critical for basal epithelial cell adhesion and wound healing (Pecorari et al., 2022). TP63 (the gene encoding p63) regulates ITGB4, one of the major integrin receptors for laminin-332 (LM332). Moreover, TP63 is also known to regulate ZNF750 (Sen et al., 2012) which in turn controls LM332 gene expression (LAMA3, LAMB3, LAMC2) (Soares et al., 2019). p63 function is dysregulated in several acquired and congenital skin diseases; notably, pathogenic variants in TP63 are responsible for several ectodermal dysplasia subtypes (Peschel et al., 2022), including Ankyloble...
Source: Journal of Investigative Dermatology - September 16, 2023 Category: Dermatology Authors: Cl ément Berthy, Laurent Gagnoux-Palacios, Marine Madrange, Christine Bodemer, Nicolas Cagnard, Smail Hadj-Rabia, Isabelle Petit, Daniel Aberdam Tags: Letters to the Editor Source Type: research
PRIMA-1MET/APR-246 Can Partially Rescue In Vitro Cell Adhesion of Patient-Derived Junctional Epidermolysis Bullosa Epidermal Cells
The epithelial transcription factor TP63 is critical for basal epithelial cell adhesion and wound healing (Pecorari et al., 2022). TP63 (the gene encoding p63) regulates ITGB4, one of the major integrin receptors for laminin-332 (LM332). Moreover, TP63 is also known to regulate ZNF750 (Sen et al., 2012), which in turn controls LM332 gene expression (LAMA3, LAMB3, LAMC2) (Soares et al., 2019). p63 function is dys regulated in several acquired and congenital skin diseases; notably, pathogenic variants in TP63 are responsible for several ectodermal dysplasia subtypes (Peschel et al., 2022), including ankyloblepharon-ecto...
Source: Journal of Investigative Dermatology - September 16, 2023 Category: Dermatology Authors: Cl ément Berthy, Laurent Gagnoux-Palacios, Marine Madrange, Christine Bodemer, Nicolas Cagnard, Smail Hadj-Rabia, Isabelle Petit, Daniel Aberdam Tags: Letters to the Editor Source Type: research
Plectin deficiency in fibroblasts deranges intermediate filament and organelle morphology, migration, and adhesion
In this study, we performed a comprehensive cell biological analysis of dermal fibroblasts from three different EBS-MD patients, where PLEC expression analyses revealed preserved mRNA levels in all cases, whereas full-length plectin protein content was significantly reduced or completely absent. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - September 14, 2023 Category: Dermatology Authors: Michaela M. Zrelski, Sabrina H ösele, Monika Kustermann, Petra Fichtinger, Delf Kah, Ioannis Athanasiou, Philipp R. Esser, Anja Wagner, Rebecca Herzog, Klaus Kratochwill, Wolfgang H. Goldmann, Dimitra Kiritsi, Lilli Winter Tags: Original Article Source Type: research
miR-200b-mediated reversion of a spectrum of epithelial to mesenchymal transition states in recessive dystrophic epidermolysis bullosa squamous cell carcinomas
CONCLUSIONS: In summary, RDEB-SCCs exist in different EMT states and the level of miR-200b is indicative of how far an RDEB-SCC has gone down the EMT path. Moreover, reintroduction of miR-200b significantly reduced mesenchymal features.PMID:37681509 | DOI:10.1093/bjd/ljad335 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 8, 2023 Category: Dermatology Authors: Julia Illmer Roland Zauner Josefina Pi ñón Hofbauer Monika Wimmer Stefanie Gruner Michael Ablinger Johannes Bischof Sonja Dorfer Stefan Hainzl Vanessa Tober Shir Bergson Ofer Sarig Liat Samuelov Christina Guttmann-Gruber Ruby Shalom-Feuerstein Eli Sprec Source Type: research
Differential diagnosis of stage 2, 3 and 4 pressure injuries of the pelvis and lower extremity: a case series
J Wound Care. 2023 Sep 1;32(Sup9):S22-S36. doi: 10.12968/jowc.2023.32.Sup9.S22.ABSTRACTConstant, unrelieved pressure of local tissue, particularly over bony prominences, may provoke damage that progresses to necrosis and pressure injury (PI). Differentiating PIs from conditions of similar appearance is imperative to minimising complications and implementing prompt treatment. This case series describes several conditions that may be mistaken for a PI. Outlined are the key differences in patient history, presentation and clinical cues that assist in correctly identifying the true pathology behind these conditions. Conditions...
Source: Herpes - September 8, 2023 Category: Infectious Diseases Authors: Jennifer Caudill Tim Chrisman Joanna Chen Kelsee Zajac Richard Simman Source Type: research
miR-200b-mediated reversion of a spectrum of epithelial to mesenchymal transition states in recessive dystrophic epidermolysis bullosa squamous cell carcinomas
CONCLUSIONS: In summary, RDEB-SCCs exist in different EMT states and the level of miR-200b is indicative of how far an RDEB-SCC has gone down the EMT path. Moreover, reintroduction of miR-200b significantly reduced mesenchymal features.PMID:37681509 | DOI:10.1093/bjd/ljad335 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 8, 2023 Category: Dermatology Authors: Julia Illmer Roland Zauner Josefina Pi ñón Hofbauer Monika Wimmer Stefanie Gruner Michael Ablinger Johannes Bischof Sonja Dorfer Stefan Hainzl Vanessa Tober Shir Bergson Ofer Sarig Liat Samuelov Christina Guttmann-Gruber Ruby Shalom-Feuerstein Eli Sprec Source Type: research
miR-200b-mediated reversion of a spectrum of epithelial to mesenchymal transition states in recessive dystrophic epidermolysis bullosa squamous cell carcinomas
CONCLUSIONS: In summary, RDEB-SCCs exist in different EMT states and the level of miR-200b is indicative of how far an RDEB-SCC has gone down the EMT path. Moreover, reintroduction of miR-200b significantly reduced mesenchymal features.PMID:37681509 | DOI:10.1093/bjd/ljad335 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 8, 2023 Category: Dermatology Authors: Julia Illmer Roland Zauner Josefina Pi ñón Hofbauer Monika Wimmer Stefanie Gruner Michael Ablinger Johannes Bischof Sonja Dorfer Stefan Hainzl Vanessa Tober Shir Bergson Ofer Sarig Liat Samuelov Christina Guttmann-Gruber Ruby Shalom-Feuerstein Eli Sprec Source Type: research
Differential diagnosis of stage 2, 3 and 4 pressure injuries of the pelvis and lower extremity: a case series
J Wound Care. 2023 Sep 1;32(Sup9):S22-S36. doi: 10.12968/jowc.2023.32.Sup9.S22.ABSTRACTConstant, unrelieved pressure of local tissue, particularly over bony prominences, may provoke damage that progresses to necrosis and pressure injury (PI). Differentiating PIs from conditions of similar appearance is imperative to minimising complications and implementing prompt treatment. This case series describes several conditions that may be mistaken for a PI. Outlined are the key differences in patient history, presentation and clinical cues that assist in correctly identifying the true pathology behind these conditions. Conditions...
Source: Herpes - September 8, 2023 Category: Infectious Diseases Authors: Jennifer Caudill Tim Chrisman Joanna Chen Kelsee Zajac Richard Simman Source Type: research
