Epidermolysis Bullosa Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Why are squamous cancers so aggressive in Recessive Dystrophic Epidermolysis Bullosa? Can we find new therapeutic approaches?
Br J Dermatol. 2023 Oct 13:ljad392. doi: 10.1093/bjd/ljad392. Online ahead of print.NO ABSTRACTPMID:37831585 | DOI:10.1093/bjd/ljad392 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 13, 2023 Category: Dermatology Authors: Ryan O'Shaughnessy Source Type: research

Genetic diagnosis of a rare COL7A1 variant causing dystrophic epidermolysis bullosa pruriginosa through whole ‑exome sequencing
In conclusion, the present study provides evidence for the involvement of the COL7A1 G2287R gene variant in the development of DEB-Pr and highlights the potential utility of cfDNA in genetic disease diagnosis.PMID:37822584 | PMC:PMC10562958 | DOI:10.3892/etm.2023.12201 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - October 12, 2023 Category: General Medicine Authors: Yanhui Yang Yangmin Gao Mengna Zhang Hua Qian Ke Zhao Weijuan Wang Yanxiu Ma Dan Zhang Xiaoguang Li Fengming Hu Xiaoming Sun Source Type: research

Challenges in the Transfer and Scale-Up of Mini-Tableting: Case Study with Losartan Potassium
Eur J Pharm Biopharm. 2023 Oct 9:S0939-6411(23)00261-8. doi: 10.1016/j.ejpb.2023.10.001. Online ahead of print.ABSTRACTMini-tablets (MTs) with losartan potassium were developed to treat the rare disease Epidermolysis Bullosa. The focus was placed on transfer and scale-up of a direct compressible formulation from the compaction simulator STYL'One Evo (CS) to the rotary tablet press Korsch XM 12 (RP). Transfer of tabletability and compactibility profiles from CS to RP did not show good agreement, e.g. at a tableting pressure of 125 MPa mean tensile strengths (TS) of 4 MPa on CS and 1-1.5 MPa on RP were reached. These results...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 11, 2023 Category: Drugs & Pharmacology Authors: Valentin ë Lura Stefan Klinken J örg Breitkreutz Source Type: research

Involvement of palms and soles in patients with autoimmune bullous diseases: a comparative analysis of a diagnostically relevant localization
We present our own clinical-laboratory experience concerning presentations of skin lesions on palms and soles in the pemphigus diseases group, pemphigoid diseases group, epidermolysis bullosa acquisita (EBA), and lichen planus pemphigoides (LPP) and discuss the pertinent literature.MethodsLesions on palms and soles were assessed retrospectively on the basis of just photographic archives from the beginning of 2014 to March 2023. We comparatively evaluated 462 Slavic patients with AIBD.ResultsPalmoplantar involvement was observed in only 21 patients with AIBD (12 females and 9 males). There was no statistically significant d...
Source: Frontiers in Immunology - October 10, 2023 Category: Allergy & Immunology Source Type: research

Retrospective analysis of autoimmune bullous diseases in Middle Franconia
This study shows that the incidence of each AIBDs in Middle Franconia is low and comparable (PV, PF, LAD, EBA) or lower (BP, MMP, DH) than in other studies and regions. BP is the most common newly diagnosed AIBD in Middle Franconia.DiscussionDue to the chronic and sometimes severe course of AIBDs, repeated in-house treatments are often necessary. To date, mainly topically and systemically applied corticosteroids in combination with immunomodulators are used as first-line therapy. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - October 10, 2023 Category: Allergy & Immunology Source Type: research

Harmonization of outcomes in epidermolysis bullosa - report of the Core Outcome Sets for Epidermolysis Bullosa (COSEB) kick-off meeting
Br J Dermatol. 2023 Oct 4:ljad361. doi: 10.1093/bjd/ljad361. Online ahead of print.NO ABSTRACTPMID:37792735 | DOI:10.1093/bjd/ljad361 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 4, 2023 Category: Dermatology Authors: Eva W H Korte Phyllis I Spuls Peter C van den Akker Dimitra Kiritsi Martin Laimer Anna M G Pasmooij Rainer Riedl Elizabeth Vroom Verena Wally Tobias Welponer Maria C Bolling Source Type: research

Infrahyoid flap —a good substitute for free flaps in oral reconstruction during the COVID‐19 pandemic
ConclusionsThe infrahyoid flap proves to be a viable alternative to free flaps for the repair of medium-sized oral defects, especially in compromised patients and during the COVID-19 pandemic. (Source: Surgical Practice)
Source: Surgical Practice - September 30, 2023 Category: Surgery Authors: Tam ‐Lin Chow, Siu‐Chung Fung, Calvin K. P. Tsui, Jeren Jin Mun Lim Tags: ORIGINAL ARTICLE Source Type: research

Correction to: The aggressive behaviour of squamous cell carcinoma in epidermolysis bullosa: analysis of clinical outcomes and tumour characteristics in the Dutch EB Registry
Br J Dermatol. 2023 Sep 23:ljad341. doi: 10.1093/bjd/ljad341. Online ahead of print.NO ABSTRACTPMID:37740985 | DOI:10.1093/bjd/ljad341 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 23, 2023 Category: Dermatology Source Type: research

Genes, Vol. 14, Pages 1835: Independent COL17A1 Variants in Cats with Junctional Epidermolysis Bullosa
This study highlights the complexity of EB in animals and contributes to a better understanding of the genotype-phenotype correlation in COL17A1-related JEB. (Source: Genes)
Source: Genes - September 22, 2023 Category: Genetics & Stem Cells Authors: Sarah Kiener Heather Troyer Daniel Ruvolo Paula Grest Sara Soto Anna Letko Vidhya Jagannathan Tosso Leeb Elizabeth A. Mauldin Ching Yang Ana Rostaher Tags: Article Source Type: research