The horror of darkened hearts
In 2016, I published A Tale of Two Epidemics in the Harvard Health Blog. Sadly, our current pandemic has joined with health professional burnout and the opioid epidemic to gobsmack us with virus-infused spittle. Although doctors and nurses have stepped up heroically to save lives, many of us are depressed and dispirited. We’ve gotten sick.Read more …The horror of darkened hearts originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 20, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/steve-adelman" rel="tag" data-wpel-link="internal" > Steve Adelman, MD < /a > < /span > Tags: Physician Psychiatry Source Type: blogs
Fight Aging! Newsletter, April 18th 2022
In conclusion, our results suggest that SAH extends lifespan by inducing MetR or mimicking its downstream effects. Since the lifespan-extending effects of SAH are conserved in yeast and nematodes, and MetR extends the lifespan of many species, exposure to SAH is expected to have multiple benefits across evolutionary boundaries. Our findings offer the enticing possibility that in humans the benefits of a MetR diet can be achieved by promoting Met reduction with SAH. The use of endogenous metabolites, such as SAH, is considered safer than drugs and other substances, suggesting that it may be one of the most feasible ways to ...
Source: Fight Aging! - April 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrially Targeted Tamoxifen as a Senolytic Drug
Researchers here note that mitochondrially targeted tamoxifen, developed as a cancer therapeutic, is sufficiently senolytic to treat conditions in which senescent cells play a significant role. They have chosen to target type 2 diabetes, a case of following the money given the present epidemic of obesity. It is actually quite surprising that few of the groups developing novel senolytic drugs have set their sights on diabetes, given the solid evidence of the past few years for the pathology of both type 1 diabetes and type 2 diabetes to be mediated in large part by cellular senescence.
Senescent cells play an impor...
Source: Fight Aging! - April 13, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Contemplating Health Data Rights as Civil Rights
BY ERIC PERAKSLIS ON BEHALF OF THE LIGHT COLLECTIVE
Recently, despite decades of experience in cybersecurity, privacy, and data science, I got sent back to school.
As a member of the Council of the Wise at the Light Collective, a patient advocacy group with a focus on healthcare technology and privacy, I attended a town hall event entitled “No Aggregation Without Representation,” which featured four eminently qualified leaders of the BIPOC and data advocacy communities: Dr Maya Rockeymore Cummings, Tiah Tomlin-Harris, Jillian Simmons, JD and Valencia Robinson. I was unprepared for the ownership and au...
Source: The Health Care Blog - March 25, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy civil rights Healthcare data Source Type: blogs
We ’re failing people with opioid use disorder [PODCAST]
“We know regulators can move quickly to confront a health crisis because we have seen it in action. During COVID, the nation eased regulatory burdens at all levels of government to help health systems and doctors leverage technology and change the way they deliver care and to drive vaccine innovation. During the AIDS epidemic, weRead more …We’re failing people with opioid use disorder [PODCAST] originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 24, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/the-podcast-by-kevinmd" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Podcast Medications Source Type: blogs
A tale of liberty
The childish refusal of so many Americans to take simple actions and endure what is at most a minor inconvenience to save the lives of their neighbors in the name of " liberty " has reminded me of many of the paradigmatic tales in public health history. I ' m going to give you one: the story of milk.From the late 19th to the late 20th Century, life expectancy in the U.S. and other wealthy countries essentially doubled. In 1880 life expectancy at birth in the U.S. was about 40 years. Now it ' s nearly 80. (We ' ve actually lost ground recently but that ' s another story.) While the death rate at all ages has declined, the b...
Source: Stayin' Alive - March 19, 2022 Category: American Health Source Type: blogs
How Do We Know If COVID Is Over?
Is it the end of COVID? – we hear this very question more and more often these days. This topic has been analysed over and over in the past two years, I also wrote about it more than once. Here, at the beginning, we outlined possible scenarios on how the pandemic will develop. By now we can determine that we ended up somewhere between #2 and #3.
We also discussed how widespread vaccination is the way to go, and how it will contribute to getting back our lives.
The speculation on finally getting over it is not surprising. It is in line with recent reports, and the discussion about the pandemic entering the endem...
Source: The Medical Futurist - March 15, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Covid-19 public health covid19 pandemic endemic end of covid Source Type: blogs
Blame to go around on the opioid epidemic
The Purdue Pharma settlement gave family members of people who were harmed by opioid prescribingthe opportunity to confront Purdue family members, a dramatic spectacle that represents some measure of justice but casts blame for the disaster of the opioid epidemic on one family. That is not the whole story, or really a true story. Prior to the 1980s, opioids were generally prescribed in the U.S. only for short-term use, after surgery or severe injury, or for people who were terminally ill.In the 1980s, for reasons which are not entirely clear, attitudes in the medical profession began to shift and physicians began to t...
Source: Stayin' Alive - March 14, 2022 Category: American Health Source Type: blogs
Sunday Sermonette: You didn't really expect it to make any sense, did you?
With Chapter 24 we come to the end of the Book of Samuel. The division seems arbitrary -- David is still around for the first couple of chapters of Kings. I suspect it has to do with the conventional length of a scroll rather than any literary consideration. In any event, this chapter is completely incoherent.God is angry at Israel for no apparent reason, so he orders David to take a census, which is somehow supposed to be a punishment? Note that Moses took several censuses, in fact that is the reason for the title of the Book of Numbers, in which there are three. Saul also took a census. This was never any problem. Anyway...
Source: Stayin' Alive - March 13, 2022 Category: American Health Source Type: blogs
Joint statement from the UK government, CEPI, IFPMA, ABPI, BIA, BIO and DCVMN on delivering the 100 Days Mission
Department of Health and Social Care - This joint statement between UK government, the Coalition for Epidemic Preparedness Innovations (CEPI) and industry associations commits to taking forward specific steps needed for future pandemic preparedness.Joint statementMore detail (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - March 8, 2022 Category: UK Health Authors: The King ' s Fund Library Tags: Covid-19 Source Type: blogs
Fight Aging! Newsletter, February 28th 2022
In conclusion, as BMI and waist circumference are related to elevations of immune markers in the IL-6 pathway, chronic inflammation might be an important mediator of the relationship between BMI and frailty.
Fat Tissue Becomes Dysfunctional with Age as Mitochondria Falter
https://www.fightaging.org/archives/2022/02/fat-tissue-becomes-dysfunctional-with-age-as-mitochondria-falter/
Mitochondria are effectively power plants, hundreds of them working in every cell to produce chemical energy store molecules to power cellular processes. Mitochondrial function declines with age, unfortunately, for underlying r...
Source: Fight Aging! - February 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
From MDPI: " The Transition to Noncommunicable Disease: How to Reduce Its Unsustainable Global Burden by Increasing Cognitive Access to Health Self-Management "
https://www.mdpi.com/1396952:The Transition to Noncommunicable Disease: How to Reduce Its Unsustainable Global Burden by Increasing Cognitive Access to Health Self-ManagementAbstract: The global epidemic of noncommunicable diseases (NCDs), such as cardiovascular disease and diabetes, is creating unsustainable burdens on health systems worldwide. NCDs are treatable but not curable. They are less amenable to top-down prevention and control than are the infectious diseases now in retreat. NCDs are mostly preventable, but only individuals themselves have the power to prevent and manage the diseases to which the enticements of ...
Source: Intelligent Insights on Intelligence Theories and Tests (aka IQ's Corner) - February 25, 2022 Category: Neuroscience Source Type: blogs
Pithiatism Redux
BY MARTIN SAMUELS
Those of us in medicine have all seen the famous painting of the Tuesday afternoon lessons at the Salpȇtrière in Paris in the 19th century. In Pierre Aristide André Brouillet’s painting, one can clearly see the great professor, Jean-Martin Charcot, holding forth while the patient, Blanche Whitman, is being supported by a tall young man, Joseph Jules Francois Felix Babinski, the Chef de Clinique (the chief resident) and allegedly the favorite to succeed Charcot. He never did as he was failed repeatedly on the exam necessary to become a faculty member at the university by a jealous, xenophobic, anti...
Source: The Health Care Blog - February 25, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Patients Physicians Andre Brouillet Martin Samuels Mental Health Patient Care Pithiatism Source Type: blogs
Harm Reduction
One of the very worst public policy mistakes of the 20th Century, one which is still with us, was the criminalization of what we now like to call Substance Use Disorder (SUD). The laws were enforced with literally grotesque inequity, filling the jails and prisons with Black and Latino people for " offenses " that white people committed at the same or even higher rates but were seldom prosecuted for. Imprisoning people is ineffective at treating SUD, but even so it is wrong to imprison people for falling victim to misfortune. It is extremely expensive, and it makes it nearly impossible for people to build a successful...
Source: Stayin' Alive - February 22, 2022 Category: American Health Source Type: blogs
Against Testosterone Treatments for Older People
This cutting opinion piece is written in opposition to the prevalence of testosterone therapy, offered in many cases with the (dubious) promise of it being a way to push back the advance of aging. Hormone therapies in general are not to be taken lightly, but are widely used. Anyone should be free to try whatever they feel may work for them, but this approach may not be justified for most people given the balance of risk and benefit. That isn't a justification for restriction of personal freedom, but rather for greater efforts to educate in the face of overly enthusiastic marketing.
It is not easy in the present en...
Source: Fight Aging! - February 22, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
