Conducting clinical trials in sub-Saharan Africa: challenges and lessons learned from the Malawi Cryptosporidium study
ConclusionThis study demonstrated that initiating and implementing human experimental trials in sub-Saharan Africa can be challenging. However, solutions exist and successful execution requires careful planning, ongoing evaluation, responsiveness to new developments, and oversight of all trial operations. (Source: Trials)
Source: Trials - July 24, 2020 Category: Research Source Type: clinical trials
Evaluating interventions to improve test, treat, and track (T3) malaria strategy among over-the-counter medicine sellers (OTCMS) in some rural communities of Fanteakwa North district, Ghana: study protocol for a cluster randomized controlled trial
DiscussionThe trial will provide evidence on the combined effectiveness of provider and community interventions in improving adherence to the T3 initiative among OTCMS in rural Ghana.Ethical clearanceNMIMR-IRB CPN 086/18-19Trial registrationISRCTN registryISRCTN77836926. Registered on 4 November 2019. (Source: Trials)
Source: Trials - July 7, 2020 Category: Research Source Type: clinical trials
The SARS-CoV-2 Ivermectin Navarra-ISGlobal Trial (SAINT) to Evaluate the Potential of Ivermectin to Reduce COVID-19 Transmission in low risk, non-severe COVID-19 patients in the first 48 hours after symptoms onset: A structured summary of a study protocol for a randomized control pilot trial
AbstractObjectivesThe primary objective is to determine the efficacy of a single dose of ivermectin, administered to low risk, non-severe COVID-19 patients in the first 48 hours after symptom onset to reduce the proportion of patients with detectable SARS-CoV-2 RNA by Polymerase Chain Reaction (PCR) test from nasopharyngeal swab at day 7 post-treatment.The secondary objectives are:To assess the efficacy of ivermectin to reduce the SARS-CoV-2 viral load in the nasopharyngeal swab at day 7 post treatment.To assess the efficacy of ivermectin to improve symptom progression in treated patients.To assess the proportion of seroco...
Source: Trials - June 7, 2020 Category: Research Source Type: clinical trials
Study on Physiologic Requirement and Dietary Recommended Nutrient Intake (RNI) of Iodine in Children
Condition: Nutritional Requirements Intervention: Other: no intervention Sponsors: Tianjin Medical University; Shandong Institute for Endemic Disease Control and Research Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - June 5, 2020 Category: Research Source Type: clinical trials
