Protocol for a randomized clinical trial exploring the effect of antimicrobial agents on the penile microbiota, immunology and HIV susceptibility of Ugandan men
DiscussionThere is a critical need to develop acceptable, simple, and effective means of HIV prevention in men unwilling to undergo PC. This trial will provide insight into the causative role of the foreskin microbiota on HIV susceptibility, and the impact of simple microbiota-focused clinical interventions. This may pave the way for future clinical trials using low-cost, nonsurgical intervention(s) to reduce HIV risk in uncircumcised heterosexual men.Trial registrationClinicalTrials.gov,NCT03412071. Retrospectively registered on 26 January 2018. (Source: Trials)
Source: Trials - July 18, 2019 Category: Research Source Type: clinical trials
Efficacy of the In2Care ® auto-dissemination device for reducing dengue transmission: study protocol for a parallel, two-armed cluster randomised trial in the Philippines
DiscussionFor decades, it has been commonly accepted that an integrated approach to mosquito control is required. The World Health Organization (WHO) Global Strategic Framework for Integrated Vector Management recommends a range of interventions, in combination, to increase control impact to reduce transmission. This efficacy trial of the first commercial product using the AD approach will be informative in assessing the general utility of AD in reducing not only adult vector densities but, more importantly, reducing the incidence of dengue. The AD technique may complement source reduction and larviciding campaigns by more...
Source: Trials - May 13, 2019 Category: Research Source Type: clinical trials
Phase 1b/2a Trial to Evaluate LEP-F1 + GLA-SE in Areas Endemic for Leprosy
Condition: Leprosy Interventions: Biological: LEP-F1 + GLA-SE; Biological: Placebo Sponsors: IDRI; Oswaldo Cruz Institute Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - May 13, 2019 Category: Research Source Type: clinical trials
Reducing the Risk of P. Vivax After Falciparum Infections in Co-endemic Areas - a Randomized Controlled Trial
Condition: Malaria Intervention: Drug: primaquine Sponsors: Menzies School of Health Research; International Centre for Diarrhoeal Disease Research, Bangladesh; Tribhuvan University, Nepal; Arba Minch University, Ethiopia Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 16, 2019 Category: Research Source Type: clinical trials
