Typhoidal Salmonella human challenge studies: ethical and practical challenges and considerations for low-resource settings
AbstractTyphoidalSalmonella is a major global problem affecting more than 12 million people annually. Controlled human infection models (CHIMs) in high-resource settings have had an important role in accelerating the development of conjugate vaccines againstSalmonella Typhi.The typhoidalSalmonella model has an established safety profile in over 2000 volunteers in high-income settings, and trial protocols, with modification, could be readily transferred to new study sites. To date, a typhoidalSalmonella CHIM has not been conducted in a low-resource setting, although it is being considered.Our article describes the challenge...
Source: Trials - December 18, 2019 Category: Research Source Type: clinical trials
Phase II Multicenter Study of Talimogene Laherparepvec in Classic or Endemic Kaposi Sarcoma
Condition: Kaposi Sarcoma Intervention: Drug: Talimogene laherparepvec Sponsor: Assistance Publique - Hôpitaux de Paris Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 22, 2019 Category: Research Source Type: clinical trials
