Precision Medicine and the Reinvention of Human Disease (Book Index)
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book ' s index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 198, 220geAcq...
Source: Specified Life - January 23, 2018 Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
It ’s Not the Death, It’s the Dying: Moral Distress in Palliative Care
by Vickie LeffEvery day, we get involved in unbelievable and incredible situations. Tragedy, sadness, horrific trauma, despair, and hopelessness all wrap themselves around the cases we drop into. We step onto the stage and become part of the story.Moral distress – the discomfort, angst, and frustration related to situations in which we think we know the “right thing” to do, but cannot due to the situation – is endemic to palliative care and hospice work. Some examples are:Aggressive chemotherapy for a dying cancer patient with days to live.Dumping the truth on a patient overwhelmed and alone.Following the trea...
Source: Pallimed: A Hospice and Palliative Medicine Blog - January 19, 2018 Category: Palliative Care Tags: moral distress social work social worker Vickie Leff Source Type: blogs
A Clinical Trial By Any Other Name …
By ARTHUR CAPLAN and KELLY McBRIDE FOLKERS
Mosquito borne illnesses pose a significant threat to human health. In the past several years, drug makers have begun developing vaccines for viruses like dengue, Zika, and chikungunya, all of which pose unique risks to billions across the globe. One of them just went terribly, terribly wrong.
Sanofi Pasteur, the vaccine division of the multinational pharmaceutical company Sanofi, has the problem. In a press release distributed last Wednesday, Sanofi reported that new analysis of long-term safety data for its dengue vaccine, Dengvaxia®, revealed that the vaccine may not be safe ...
Source: The Health Care Blog - December 7, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Dengue Source Type: blogs
Funtabulously Frivolous Friday Five 215
LITFL • Life in the Fast Lane Medical Blog
LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 215.
Question 1
Sir Robert Jones from last week’s FFFF came from a strong line of ‘bone setters’, who was his uncle and what device did Jones promote that his uncle invented in World War one to reduce mortality in wounded soldiers?
+ Reveal the Fu...
Source: Life in the Fast Lane - November 24, 2017 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five Congenital central Hypoventilation syndrome Femur fracture Hugh Owen Thomas John Stapp Jones melioidosis murphy's law Nightcliff Gardner's disease Ondine Ondine's curse Religio Medici Thomas Browne Thomas sp Source Type: blogs
Stash House Stings: When the Government Can Invent Crimes and Criminals
Imagine a friend approaches you with an opportunity for what he believes will be easy money: a guy he met knows where some local drug dealers store their merchandise —a great big pile of it, fifty kilos, lightly guarded. Your friend’s guy thinks it could be grabbed relatively easily and flipped for a hefty profit. The whole thing sounds sketchy to you, but cash is tight this month and stealing from drug dealers does not feel like the most morally objectionab le of crimes. Perhaps not the most sophisticated sort (andhaving watched a bit too much TV), you soon find yourself in a van on your way to the score.Except there ...
Source: Cato-at-liberty - November 22, 2017 Category: American Health Authors: Trevor Burrus, Reilly Stephens Source Type: blogs
Christopher Robin: a sad story
Jump to follow-up
Today we went to see the film, Goodbye Christopher Robin. It was very good. I, like most children, read Pooh books as a child.
Image from Wikipedia
I got interested in their Author, A.A. Milne, when I discovered that he’d done a mathematics degree at Cambridge. So had my scientific hero A.V. Hill, and (through twitter) I met AV’s granddaughter, Alison Hill. I learned that AV loved to quote A.A.Milne’s poem, OBE.
O.B.E.
I know a Captain of Industry,
Who made big bombs for the R.F.C.,
And collared a lot of £ s. d.–
And he–thank God!–h...
Source: DC's goodscience - November 8, 2017 Category: Science Authors: David Colquhoun Tags: A.V. Hill AA Milne AV Hill Christopher Robin PTSD Winnie the Pooh Source Type: blogs
Christopher Robin: a sad story
Jump to follow-up
Today we went to see the film Goodbye Christopher Robin. It was very good. I, like most children, read Pooh books as a child.
Image from Wikipedia
I got interested in their author, A.A. Milne, when I discovered that he’d done a mathematics degree at Cambridge. So had my scientific hero A.V. Hill, and (through twitter) I met AV’s granddaughter, Alison Hill. I learned that AV loved to quote A.A.Milne’s poem, OBE.
O.B.E.
I know a Captain of Industry,
Who made big bombs for the R.F.C.,
And collared a lot of £ s. d.–
And he–thank God!–ha...
Source: DC's goodscience - November 8, 2017 Category: Science Authors: David Colquhoun Tags: A.V. Hill AA Milne AV Hill Christopher Robin PTSD Winnie the Pooh Source Type: blogs
The challenge of “ evidence based ” sore throat guidelines
CONCLUSION Although the evidence for the management of acute sore throat is easily available, national guidelines are different with regard to the choice of evidence and the interpretation for clinical practice. Also a transparent and standardized guideline development method is lacking. These findings are important in the context of appropriate antibiotic use, the problem of growing antimicrobial resistance, and costs for the community.
We assume that the word “evidence” is all inclusive. How can 9 guidelines on one subject differ significantly? The first problem occurs in selecting the evidence. Like ...
Source: DB's Medical Rants - October 23, 2017 Category: Internal Medicine Authors: rcentor Tags: Medical Rants Source Type: blogs
Digital Maps Help Fight Epidemics
Have you ever thought that it would be possible to monitor drug overdoses, Zika cases or the spread of the flu in real time? Have you ever imagined that satellites wouldbe able to tell how and where a malaria epidemic will happen months before the actual outbreak? It is mind-blowing how, in the last years, digital maps developed to a level where they serve as effective tools for evaluating, monitoring and even predicting health events. That’s why I decided to give a comprehensive overview of digital maps in healthcare.
John Snow, cholera and the revolution of maps in healthcare
Before Game of Thrones monopolized John Sn...
Source: The Medical Futurist - October 12, 2017 Category: Information Technology Authors: nora Tags: Future of Medicine Healthcare Design Mobile Health digital health digital technology epidemics epidemiology gc4 Innovation interactive maps Source Type: blogs
Chikungunya Outbreak Halts Blood Collection in Parts of Rome
As a former blood banker, I often take notice of the relationship between blood donation and infectious disease, a sensitivity that harks back to the AIDS era. A recent article noted that blood donations were being halted in parts of Rome because of an outbreak of Chikungunya (see:Outbreak of disease carried by mosquitoes halts blood donation in Rome), Below is an excerpt from it:Italian health officials have banned residents across half of Rome from donating blood because of an outbreak of the painful, mosquito-borne illness Chikungunya. At least 17 people in southeastern Rome have been diagnosed with the virus sinc...
Source: Lab Soft News - September 18, 2017 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Blood banking Clinical Lab Industry News Clinical Lab Testing Medical Consumerism Medical Research Source Type: blogs
Hookworm in the United States
The following background data on hookworm in the United States are abstracted from Gideon www.GideonOnlne.com. Primary references are available on request.
Hookworm was formerly common in the South and Southeast, with highest rates among children. 7,391 cases of ancylostomiasis were officially notified through optional reporting during 1967 to 1969, including 4,831 (65.4%) from Georgia. In 1987, 68.7% of positive state laboratory reports were submitted from California, Wisconsin, Rhode Island, Colorado and Washington.
Prevalence surveys:
Year(s) / Region / Details
1909-1914 / South / 40% of the general population
194...
Source: GIDEON blog - September 16, 2017 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: General Source Type: blogs
The Shame of US Health Care Dysfunction: Hookworm Returns to Alabama
ConclusionsAs we have noted endlessly, the US spends more per capita on health care than any other developed country. US politicians used to make the claim that the country has the best health care system in the world, often to ward off any attempts at true health care reform. However, US rankings on various measures - some of which may be disputed - of health care processes and outcomes have been decidedly mediocre. (See for example the latest Commonwealth Fund studyhere.)The new study of hookworm prevalence was not based on a big, systematic, or geographically diverse sample. However it is strikin...
Source: Health Care Renewal - September 7, 2017 Category: Health Management Tags: government health care foundations public health Source Type: blogs
Answer to Case 459
Answer:Strongyloides stercoralisinfection.Seen here are numerous rhabditiformS. stercoralislarvae, some possible filariform larvae, and embryonated eggs with viable larvae within. This level of infection is consistent withStrongyloideshyperinfection and warrants a rapid call to the clinical team to alert them to the diagnosis.There were a lot of great comments on this case. Florida Fan, Angelica Maria and Khalid Elfeel nicely discussed the presence of the short buccal cavity and genital primordium - keys feature for differentiating the rhabditiform (L1) larvae ofS. stercoralisfrom the similar-appearing larvae of the hookwo...
Source: Creepy Dreadful Wonderful Parasites - September 3, 2017 Category: Parasitology Source Type: blogs
Answer to Case 457
Answer:Cyclospora cayetanensisoocystsThanks again to Florida Fan for providing these colorful images. Idzi Potters mentioned thatC. cayetanensisoocysts also produce beautiful autofluorescence. Instructions for observing their autofluorescence can be foundHERE) Below is an image that Florida Fan gave me a while back which nicely highlights this phenomenon (oocysts are denoted by arrows):Examination for autofluorescencing oocysts can be a quick way to screen forC. cayetanensisin stool, keeping in mind that other objects (including many non-parasites) will also exhibit autofluorescence. The regular size and smooth round shape...
Source: Creepy Dreadful Wonderful Parasites - August 20, 2017 Category: Parasitology Source Type: blogs
