Pediatric Conjunctivitis a Simple Diagnosis Until It Isn’t
​Conjunctivitis is a common condition and easy enough to treat, but several uncommon conjunctivitis syndromes require more care and should not be missed.Conjunctivitis is either infectious (viral or bacterial) or noninfectious (allergic or nonallergic). Viral infections are more common in adults, bacterial ones in children, usually caused by Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Adults tend to have more S. aureus infections, while the other pathogens are more common in children. An adenovirus is typically responsible for viral-associated infections in conjunct...
Source: M2E Too! Mellick's Multimedia EduBlog - March 1, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, October 8th 2018
This article, unfortunately paywalled, is interesting to note as a mark of the now increasingly energetic expansion of commercial efforts in longevity science. David Sinclair has been building a private equity company to work in many areas relevant to this present generation of commercial longevity science; while I'm not sold on his primary research interests as the basis for meaningful treatments for aging, he is diversifying considerably here, including into senolytics, the clearance of senescent cells demonstrated to produce rejuvenation in animal studies. This sort of approach to business mixes aspects of investing and...
Source: Fight Aging! - October 7, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Commentary on Recent Research into Mitochondrial DNA and Aging
Today I'll point out a commentary on recent research in which a method of degrading mitochondrial function was shown to produce aspects of accelerated aging in mice. The commentary is somewhat more approachable than the paper it comments on. The challenge here is the same as in any form of research in which something vital is broken in animal biochemistry, and wherein the result looks a lot like a faster pace of aging. These forms of artificial breakage are almost never relevant to the understanding of normal aging; they create an entirely different state of metabolism and decline.
It is true that normal aging is a ...
Source: Fight Aging! - October 1, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, July 30th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - July 29, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Breaking and Then Fixing Mouse Biochemistry is Not Reversing Aging
A recent example of research in which researchers break the mitochondrial biochemistry of mice and then reverse that breakage is doing the rounds in the press, being pitched as a reversal of aging. It is not a reversal of aging, however, and I'd say that the researchers involved still have to prove that the particular breakage that they engineered is in fact relevant in normal aging. The appearance of similar outcomes between the breakage and aging does not mean that it is relevant.
Why is this the case? Aging is an accumulation of specific forms of biochemical damage that leads to widespread tissue dysfunction. Giv...
Source: Fight Aging! - July 23, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Tropical Travel Trouble 007 Mega Malaria Extravaganza
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
aka Tropical Travel Trouble 007
When you think tropical medicine, malaria has to be near the top. It can be fairly complex and fortunately treatment has become a lot simpler. This post is designed to walk you through the basic principals with links to more in depth teaching if your niche is travel medicine, laboratory diagnostics or management of severe or cerebral malaria. If you stubbled on this post while drinking a cup of tea or sitting on the throne and want a few basi...
Source: Life in the Fast Lane - April 5, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Clinical Cases Tropical Medicine malaria Plasmodium plasmodium falciparum plasmodium knowles plasmodium malariae plasmodium ovale plasmodium vivax Source Type: blogs
Tropical Travel Trouble 006 Watery Diarrhoea
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
aka Tropical Travel Trouble 006
Our medical student who caught shigella on a Nepalese elective has a thirst for adventure. They plan to help at a Bangladesh refugee camp but the latest CDC report states there have been some cases of cholera. They’ve done a little bit of reading and want your help to teach them all about cholera and how they may prepare and best serve their new community.
Questions:
Q1. What is cholera and how is it transmitted?
Answer and interpreta...
Source: Life in the Fast Lane - March 27, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Clinical Cases Tropical Medicine cholera diarrhoea john snow ORS rice water diarrhoea watery diarrhoea Source Type: blogs
Funtabulously Frivolous Friday Five 231
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 231.
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Question 1:
You find yourself on holiday in Africa helping out with a dermatology clinic (yes, your forte as an emergency physician). In the queue is a young boy who describes a papular â€...
Source: Life in the Fast Lane - March 22, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five anthrax cholera Dilip Mahalanabis Dr Bayford dysentery dysphagia lusoria ORS saber shins Thomas Hodgkin wool-sorters disease yaws Source Type: blogs
Funtabulously Frivolous Friday Five 224
LITFL • Life in the Fast Lane Medical Blog
LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 224.
Question 1
Which children’s author wrote “The Pocket Book of Boners”?
+ Reveal the Funtabulous Answer
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Dr Seuss
It was one of the bestselling b...
Source: Life in the Fast Lane - February 2, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five boners coffee cups Dr Seuss Dr Thomas Neill Cream faecal matter mazzotti reaction onchocerciasis penile injury Zippers Source Type: blogs
Fight Aging! Newsletter, October 30th 2017
In this study, the researchers showed a causal link between dynamic changes in the shapes of mitochondrial networks and longevity.
The scientists used C. elegans (nematode worms), which live just two weeks and thus enable the study of aging in real time in the lab. Mitochondrial networks inside cells typically toggle between fused and fragmented states. The researchers found that restricting the worms' diet, or mimicking dietary restriction through genetic manipulation of an energy-sensing protein called AMP-activated protein kinase (AMPK), maintained the mitochondrial networks in a fused or "youthful" state. In add...
Source: Fight Aging! - October 29, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Interview with Yuri Deigin of Youthereum Genetics: the Merging of an Initial Coin Offering and Pluripotency Factors
Initial coin offerings (ICOs) are driving most of the light and heat in the blockchain world these days. People are raising enormous sums in cryptocurrencies for ventures with somewhere between little plausibility and ordinary levels of startup plausibility. In many ways it looks a lot like the last years of the internet bubble way back when; there are a lot of parallels. The flows of funding may be driven by some combination of people bypassing Chinese currency controls, early holders of Bitcoins and Ether diversifying their holdings within the blockchain ecosystem, and various large investment concerns whose owners have ...
Source: Fight Aging! - October 27, 2017 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
MKSAP: 46-year-old man with fever, dysuria, and urinary frequency
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 46-year-old man is evaluated for fever, dysuria, and urinary frequency of 1 day’s duration. He also notes a sensation of deep pelvic pain near the rectum. He has no urethral discharge or testicular pain. He states that he felt well before the current illness and has no other symptoms. Medical history is unremarkable. He is not sexually active. He takes no medications.
On physical examination, temperature is 38.8 °C (101.8 °F), blood pressure is 130/80 mm Hg, pulse rate is 100/min, and respiration rate ...
Source: Kevin, M.D. - Medical Weblog - September 9, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Infectious Disease Primary Care Urology Source Type: blogs
Skin Grafts for Gene Therapy Could Treat Type II Diabetes and Obesity
Scientists at the University of Chicago genetically modified skin cells to produce glucagon-like peptide 1 (GLP1) protein that is beneficial in diabetes and reduces appetite, and these investigators grew the cells in a dish to form a skin graft. The grafts could potentially be used to treat diabetes and obesity, and could provide a new way to perform gene therapy for a variety of diseases.
When normal and gene-altered mice ate the high-fat diet — along with varying levels of doxycycline to induce GLP1 release — mice expressing GLP1 (left) gained less weight gain while normal mice (right) grew fat. Credit: Wu L...
Source: Medgadget - August 4, 2017 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Medicine News Source Type: blogs
MKSAP: 21-year-old woman with mosquito bites
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 21-year-old woman is evaluated for mosquito bites on her arms and legs that she received 1 week ago that she has been scratching regularly. One of the bites on her left thigh is now painful with a small amount of drainage. She otherwise feels well, has no significant medical history, and takes no medications.
On physical examination, vital signs are normal. A weeping red papule with overlying honey-colored crust is present on the anterior left thigh. There is no surrounding or extension of the redness, no lymp...
Source: Kevin, M.D. - Medical Weblog - July 1, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Infectious disease Source Type: blogs
Pharmaceutical Product Hopping: A Proposed Framework For Antitrust Analysis
Skyrocketing drug prices are in the news. Overnight price increases have riveted the attention of the public, media, and politicians of all stripes. But one reason for high prices has flown under the radar. When drug companies reformulate their product, switching from one version of a drug to another, the price doesn’t dramatically increase. Instead, it stays at a high level for longer than it otherwise would have without the switch. Although more difficult to discern than a price spike, this practice, when undertaken to prevent generic market entry, can result in the unjustified continuation of monopoly pricing, burdeni...
Source: Health Affairs Blog - June 1, 2017 Category: Health Management Authors: Michael Carrier and Steve Shadowen Tags: Costs and Spending Drugs and Medical Innovation antitrust drug reformulations Hatch-Waxman Act prescription drug prices product hopping Source Type: blogs
