Possible Tracheal Relaxant and Antimicrobial Effects of the Essential Oil of Ethiopian Thyme Species (Thymus serrulatus Hochst. ex Benth.): A Multiple Mechanistic Approach
The genus Thymus is traditionally used for the treatment of hyperactive airways complaints. The purpose of the current study is to investigate the potential tracheal relaxant effect and possible mechanism(s) of the essential oil of Thymus serrulatus (TS Oil) in isolated guinea pig tracheal tissues. The essential oil was obtained from the fresh erial parts of Thymus serrulatus, and its phyto-components were identified by GC-MS analysis. Guinea pig tracheal preparations were used for testing the tracheal relaxant effect of TS Oil with the determination of the mechanism(s) involved in this relaxation. GC-MS findings reveal th...
Source: Frontiers in Pharmacology - April 5, 2021 Category: Drugs & Pharmacology Source Type: research
An adenoviral vector encoded with the GPx-1 gene attenuates memory impairments induced by β-amyloid (1-42) in GPx-1 KO mice via activation of M1 mAChR-mediated signaling.
Authors: Shin EJ, Lee SH, Sharma N, Nguyen BT, Chung YH, Kang SW, Nah SY, Lee YJ, Nabeshima T, Jeong JH, Kim HC
Abstract
In the present study, we examined whether glutathione peroxidase-1 (GPx-1), a major H2O2 scavenger in the brain, affects memory deficits induced by Aβ (1-42) in mice. Treatment with 400 pmol/5μl Aβ (1-42) (i.c.v.) resulted in a reduction of GPx-1 expression in wild type (WT) mice. An Aβ (1-42)-induced reduction in acetylcholine (ACh) level was observed in the hippocampus. Treatment with Aβ (1-42) consistently resulted in reduced expression and activity of choline acetyltransferase...
Source: Free Radical Research - November 24, 2020 Category: Research Tags: Free Radic Res Source Type: research
Investigation of anti-Parkinson activity of dicyclomine
Volume 132, Issue 4, April 2022, Page 338-351 . (Source: International Journal of Neuroscience)
Source: International Journal of Neuroscience - September 11, 2020 Category: Neuroscience Authors: Maham Sanawar Uzma Saleem Fareeha Anwar Samra Nazir Muhammad Furqan Akhtar Bashir Ahmad Tariq Ismail Source Type: research
Investigation of anti-Parkinson activity of dicyclomine
. (Source: International Journal of Neuroscience)
Source: International Journal of Neuroscience - September 10, 2020 Category: Neuroscience Authors: Maham Sanawar Uzma Saleem Fareeha Anwar Samra Nazir Muhammad Furqan Akhtar Bashir Ahmad Tariq Ismail Source Type: research
Multiple Mechanisms of Flaxseed: Effectiveness in Inflammatory Bowel Disease.
Conclusions: Results of this study, taken together with previous studies, suggest that Flaxseed possesses anti-inflammatory, antibacterial, and antispasmodic action through multiple pathways and thus offers promising potential to be developed for IBD.
PMID: 32765633 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - August 14, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Synergistic and antagonistic drug interactions in the treatment of systemic fungal infections
Invasive fungal infections cause 1.6 million deaths annually, primarily in immunocompromised individuals. Mortality rates are as high as 90% due to limited treatments. The azole class antifungal, fluconazole, is widely available and has multi-species activity but only inhibits growth instead of killing fungal cells, necessitating long treatments. To improve treatment, we used our novel high-throughput method, the overlap2 method (O2M) to identify drugs that interact with fluconazole, either increasing or decreasing efficacy. We identified 40 molecules that act synergistically (amplify activity) and 19 molecules that act an...
Source: eLife - May 5, 2020 Category: Biomedical Science Tags: Genetics and Genomics Microbiology and Infectious Disease Source Type: research
Table: Safety of Drugs for IBS in Pregnancy and Lactation (online only)
Date: March 23, 2020
Issue #:
1594Summary:
View the Table: Safety of Drugs for IBS in Pregnancy and Lactation (Source: The Medical Letter)
Source: The Medical Letter - March 13, 2020 Category: Drugs & Pharmacology Authors: admin Tags: Alosetron amitiza Amitriptyline bentyl Celexa Cholestyramine Citalopram Colesevelam Colestid Colestipol Desipramine dicyclomine eluxadoline fluoxetine Hyoscyamine Ibsrela irritable bowel syndrome Levsin linaclotide Li Source Type: research
