Molecules, Vol. 26, Pages 6348: The Spasmolytic, Bronchodilator, and Vasodilator Activities of Parmotrema perlatum Are Explained by Anti-Muscarinic and Calcium Antagonistic Mechanisms
This study evaluates the underlying mechanisms for traditional uses of P. perlatumin diarrhea, asthma, and hypertension. In vitro pharmacological studies were conducted using isolated jejunum, trachea, and aortic preparations, while the cytotoxic study was conducted in mice. Crude extract of P. perlatum(Pp.Cr), comprising appreciable quantities of alkaloids and flavonoids, relaxed spontaneously contracting jejunum preparation, K+ (80 mM)-induced, and carbachol (1 µM)-induced jejunum contractions in a concentration-dependent manner similar to dicyclomine and dantrolene. Pp.Cr showed a rightward parallel shift of concentrat...
Source: Molecules - October 20, 2021 Category: Chemistry Authors: Musaddique Hussain Hazoor Bakhsh Shahzada Khurram Syed Malik Saad Ullah Ali M. Alqahtani Taha Alqahtani Afaf A. Aldahish Talha Bin Emran Kashif Ur Rehman Khalid Hussain Janbaz Tags: Article Source Type: research

Formulation and evaluation of hydroxypropylmethylcellulose-dicyclomine microsponges for colon targeted drug delivery: In vitro and in vivo evaluation
CONCLUSION: The current study shows a new approach for colon specific delivery of DCH based on microsponges.PMID:34353263 | DOI:10.2174/1567201818666210805153347 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Muhammad Sher Rai Muhammad Sarfaraz Sadia Iqbal Muhammad Ajaz Hussain Muhammad Naeem-Ul-Hassan Faiza Hassan Syed Nasir Abbas Bukhari Source Type: research

Formulation and evaluation of hydroxypropylmethylcellulose-dicyclomine microsponges for colon targeted drug delivery: In vitro and in vivo evaluation
CONCLUSION: The current study shows a new approach for colon specific delivery of DCH based on microsponges.PMID:34353263 | DOI:10.2174/1567201818666210805153347 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Muhammad Sher Rai Muhammad Sarfaraz Sadia Iqbal Muhammad Ajaz Hussain Muhammad Naeem-Ul-Hassan Faiza Hassan Syed Nasir Abbas Bukhari Source Type: research

Formulation and evaluation of hydroxypropylmethylcellulose-dicyclomine microsponges for colon targeted drug delivery: In vitro and in vivo evaluation
CONCLUSION: The current study shows a new approach for colon specific delivery of DCH based on microsponges.PMID:34353263 | DOI:10.2174/1567201818666210805153347 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Muhammad Sher Rai Muhammad Sarfaraz Sadia Iqbal Muhammad Ajaz Hussain Muhammad Naeem-Ul-Hassan Faiza Hassan Syed Nasir Abbas Bukhari Source Type: research

Formulation and evaluation of hydroxypropylmethylcellulose-dicyclomine microsponges for colon targeted drug delivery: In vitro and in vivo evaluation
CONCLUSION: The current study shows a new approach for colon specific delivery of DCH based on microsponges.PMID:34353263 | DOI:10.2174/1567201818666210805153347 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Muhammad Sher Rai Muhammad Sarfaraz Sadia Iqbal Muhammad Ajaz Hussain Muhammad Naeem-Ul-Hassan Faiza Hassan Syed Nasir Abbas Bukhari Source Type: research

Formulation and evaluation of hydroxypropylmethylcellulose-dicyclomine microsponges for colon targeted drug delivery: In vitro and in vivo evaluation
CONCLUSION: The current study shows a new approach for colon specific delivery of DCH based on microsponges.PMID:34353263 | DOI:10.2174/1567201818666210805153347 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Muhammad Sher Rai Muhammad Sarfaraz Sadia Iqbal Muhammad Ajaz Hussain Muhammad Naeem-Ul-Hassan Faiza Hassan Syed Nasir Abbas Bukhari Source Type: research

Formulation and evaluation of hydroxypropylmethylcellulose-dicyclomine microsponges for colon targeted drug delivery: In vitro and in vivo evaluation
CONCLUSION: The current study shows a new approach for colon specific delivery of DCH based on microsponges.PMID:34353263 | DOI:10.2174/1567201818666210805153347 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Muhammad Sher Rai Muhammad Sarfaraz Sadia Iqbal Muhammad Ajaz Hussain Muhammad Naeem-Ul-Hassan Faiza Hassan Syed Nasir Abbas Bukhari Source Type: research

Formulation and evaluation of hydroxypropylmethylcellulose-dicyclomine microsponges for colon targeted drug delivery: In vitro and in vivo evaluation
CONCLUSION: The current study shows a new approach for colon specific delivery of DCH based on microsponges.PMID:34353263 | DOI:10.2174/1567201818666210805153347 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Muhammad Sher Rai Muhammad Sarfaraz Sadia Iqbal Muhammad Ajaz Hussain Muhammad Naeem-Ul-Hassan Faiza Hassan Syed Nasir Abbas Bukhari Source Type: research

Formulation and evaluation of hydroxypropylmethylcellulose-dicyclomine microsponges for colon targeted drug delivery: In vitro and in vivo evaluation
CONCLUSION: The current study shows a new approach for colon specific delivery of DCH based on microsponges.PMID:34353263 | DOI:10.2174/1567201818666210805153347 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Muhammad Sher Rai Muhammad Sarfaraz Sadia Iqbal Muhammad Ajaz Hussain Muhammad Naeem-Ul-Hassan Faiza Hassan Syed Nasir Abbas Bukhari Source Type: research

A rare case of dicyclomine and mefenamic acid abuse fulfilling criteria of dependence syndrome
Indian J Psychiatry. 2020 Nov-Dec;62(6):740-741. doi: 10.4103/psychiatry.IndianJPsychiatry_562_19. Epub 2020 Dec 12.NO ABSTRACTPMID:33896989 | PMC:PMC8052875 | DOI:10.4103/psychiatry.IndianJPsychiatry_562_19 (Source: Indian Journal of Psychiatry)
Source: Indian Journal of Psychiatry - April 26, 2021 Category: Psychiatry Authors: Santosh Kumar Sinha Shyla Dhiman Ajeet Sidana Source Type: research