Fight Aging! Newsletter, May 27th 2019
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - May 26, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Considering the Experience of Being One of the Last Mortals
With the development of rejuvenation therapies underway, and accelerating, somewhere ahead lies a dividing line. Some people will be the last to age to death, too comprehensively damaged for the technologies of the time to recover. Everyone else will live indefinitely in youth and health, protected from aging by periodic repair of the underlying cell and tissue damage that causes dysfunction and disease. Where is that dividing line? No one can say in certainty. I look at the children of today, with long lives ahead of them, and find it hard to believe that in a hundred years the problem won't be solved well in time for the...
Source: Fight Aging! - May 22, 2019 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
This Diary Study Just Happened To Be Taking Place When Disaster Struck, Providing A Rare Insight Into Vicarious Experience Of Traumatic Events
By Matthew Warren
Major disasters clearly take a toll on the survivors who had the misfortune to go through them. But there is another group of people who can suffer mental and physical distress from disasters: those who experience them second-hand, through media coverage and conversation. After 9/11, for example, researchers found an increase in symptoms of depression and stress among Americans who hadn’t directly experienced the terrorist attacks.
But there have always been doubts about studies purporting to show evidence of vicarious distress. Because disasters occur randomly researchers are usually unable to gather...
Source: BPS RESEARCH DIGEST - March 1, 2019 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: Mental health Source Type: blogs
Ultrasound Case 040
A 22 year old man presents with abdominal pain and diarrhoea. He has 3 months of intermittent diarrhoea sometimes with blood, accompanied with weight loss and abdominal discomfort.
The post Ultrasound Case 040 appeared first on Life in the Fast Lane. (Source: Life in the Fast Lane)
Source: Life in the Fast Lane - December 31, 2018 Category: Emergency Medicine Authors: Dr James Rippey Tags: Gastroenterology TOP 100 Ultrasound Bowel ultrasound Crohn's disease Inflammatory bowel disease Source Type: blogs
Last Month in Oncology with Dr. Bishal Gyawali
By BISHAL GYAWALI MD
Me-too deja vu
I read the report of a phase 3 RCT of a “new” breast cancer drug but I had the feeling that I had already read this before. Later I realized that this was indeed a new trial of a new drug, but that I had read a very similar report of a very similar drug with very similar results and conclusions. This new drug is a PARP inhibitor called talazoparib and the deja vu was related to another PARP inhibitor drug called olaparib tested in the same patient population of advanced breast cancer patients with a BRCA mutation. The control arms were the same: physician choice of drug, except t...
Source: The Health Care Blog - November 8, 2018 Category: Consumer Health News Authors: matthew holt Tags: Drug Discovery Pharmaceuticals Bishal Gyawali Cancer immunotherapy Oncology Source Type: blogs
Funtabulously Frivolous Friday Five 246
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 246
Readers can subscribe to FFFF RSS or subscribe to the FFFF weekly EMAIL
Question 1
What is so special about this watch and who invented the concept?
+ Reveal the funtabulous answer
expand(document.getElementById('ddet745509652'));expand(document.getElementByI...
Source: Life in the Fast Lane - July 26, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five Basedow disease Battle's incision Battle’s sign Cardioversion doplr watch Graves disease John Floyer Parry's disease physicians watch pulsometer Royal Humane Society tattoo-to-teeth ratio William Henry Bat Source Type: blogs
Funtabulously Frivolous Friday Five 246
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 246
Readers can subscribe to FFFF RSS or subscribe to the FFFF weekly EMAIL
Question 1
What is so special about this watch and who invented the concept?
+ Reveal the funtabulous answer
expand(document.getElementById('ddet1125060832'));expand(document.getElementBy...
Source: Life in the Fast Lane - July 26, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five Basedow disease Battle's incision Battle’s sign Cardioversion doplr watch Graves disease John Floyer Parry's disease physicians watch pulsometer Royal Humane Society tattoo-to-teeth ratio William Henry Bat Source Type: blogs
Tropical Travel Trouble 009 Humongous HIV Extravaganza
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
aka Tropical Travel Trouble 009
The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with a low ...
Source: Life in the Fast Lane - July 7, 2018 Category: Emergency Medicine Authors: Amanda McConnell Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs
Tropical Travel Trouble 006 Watery Diarrhoea
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
aka Tropical Travel Trouble 006
Our medical student who caught shigella on a Nepalese elective has a thirst for adventure. They plan to help at a Bangladesh refugee camp but the latest CDC report states there have been some cases of cholera. They’ve done a little bit of reading and want your help to teach them all about cholera and how they may prepare and best serve their new community.
Questions:
Q1. What is cholera and how is it transmitted?
Answer and interpreta...
Source: Life in the Fast Lane - March 27, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Clinical Cases Tropical Medicine cholera diarrhoea john snow ORS rice water diarrhoea watery diarrhoea Source Type: blogs
Tropical Travel Trouble 005 RUQ Pain and Jaundice
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
aka Tropical Travel Trouble 005
Guest Post: Dr Branden Skarpiak – Global Health Fellow, Department of Emergency Medicine. UT Health San Antonio
A 35 year old male presents to your emergency room for right upper quadrant pain that has gotten worse over the last 2-3 days. He also describes associated nausea, vomiting, and fevers. He denies other abdominal pain, or change in his bowel or bladder habits. His wife notes that he has started to “look more yellow” recent...
Source: Life in the Fast Lane - March 19, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Clinical Cases Tropical Medicine amebic amoeba amoebiasis amoebic dysentery amoebic liver abscess bloody diarrhoea e.dispar e.histolytica entamoeba histolytica Source Type: blogs
DuPont and Inbiose infant formula HMO gains EU approval
The ingredient 2’-Fucosyllactose (2’-FL) is to be marketed by DuPont under the brand name CARE4U, having already been approved for use in dietary supplements.
DuPont have earmarked the HMO as a core ingredient in potential applications for the future that are related to digestion and immune health.
“The substantial equivalence dossier for 2’-FL received EU Novel Food approval in December 2017,” said Paul Tenning, DuPont’s regulatory affairs manager, EMEA.
“We are excited to be able to bring this important new ingredient for infants and children into the European market.”
2016 agreement
News ...
Source: Nursing Comments - March 13, 2018 Category: Nursing Authors: M1gu3l Tags: Nutrition Source Type: blogs
Tropical Travel Trouble 004 Bloody Diarrhoea
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
aka Tropical Travel Trouble 004
A medical student who has just returned from their elective in Nepal presents with 1 week of bloody diarrhoea. He has been in the lowlands and stayed with a family in the local village he was helping at. It started three days before he left and he decided to get home on the plane in the hope it would settle. He is now opening his bowels 10x a day with associated cramps, fevers and has started feeling dizzy.
Questions:
Q1. What is dysentery ...
Source: Life in the Fast Lane - March 12, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Clinical Cases Tropical Medicine amoebic dysentery bacillary dysentery e.histolytica entamoeba histolytica shigellosis Source Type: blogs
Eponymythology: Diffuse Toxic Goitre
LITFL • Life in the Fast Lane Medical Blog
LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
Despite a drive to provide a consistent, modern nomenclature for signs, symptoms, diseases, procedures, equipment and medical conditions…eponyms still persist. We review 500 *common eponyms, the person behind their origin, history, accuracy, relevance today, modern nosology and their eponymythology.
The problem of nomenclature of diffuse toxic goitre (Parry, Graves or Basedow disease) remains an unsettled one. So lets review the chronological history of eponymous aet...
Source: Life in the Fast Lane - February 6, 2018 Category: Emergency Medicine Authors: Mike Cadogan Tags: Eponymythology Basedow disease Caleb Hillier Parry exophthalmos goiter Graves disease Karl Adolph von Basedow Parry disease Robert James Graves thyroid Source Type: blogs
LITFL Review 306
LITFL • Life in the Fast Lane Medical Blog
LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
Welcome to the 306th LITFL Review! Your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chunk of FOAM.
The Most Fair Dinkum Ripper Beauts of the Week
RebelEM unleashes his top 10 pearls from ACEP17 [LP]
EPMonthly published an ER account of the...
Source: Life in the Fast Lane - November 13, 2017 Category: Emergency Medicine Authors: Marjorie Lazoff, MD Tags: LITFL review #FOAMped #FOAMresus #FOAMsim #FOAMus #meded FOAMcc FOAMed LITFL R/V Source Type: blogs
