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Evidence of secular trends during the COVID-19 pandemic in a stepped wedge cluster randomized trial examining sexual and reproductive health outcomes among Indigenous youth
ConclusionFindings suggest evidence of a secular trend. This trend must be accounted for at trial end, and sensitivity analyses are recommended. Documenting and reporting on these findings encourages transparent reporting during the implementation of a SWD trial during a global pandemic, and informs endline analyses.Trial registrationThis trial is registered with the Clinical trials registry of the US National Library of Medicine at the National Institutes of Health (NIH). It was registered on October 1, 2018. The study presented in this manuscript is funded by NIH National Institute on Minority Health and Health Dispariti...
Source: Trials - April 1, 2023 Category: Research Source Type: clinical trials

Electronic health records to capture primary outcome measures: two case studies in HIV prevention research
ConclusionsOur experience of using the UKHSA database of HIV diagnoses as a source of primary outcomes in two randomised trials in the field of HIV prevention was highly favourable and encourages the use of a similar approach in future trials in this disease area. (Source: Trials)
Source: Trials - March 31, 2023 Category: Research Source Type: clinical trials

IMOvifa Perimeter Reference Database
Condition: Normal Eyes Intervention: Device: Visual field Sponsor: New View Optometric Center Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 30, 2023 Category: Research Source Type: clinical trials

Timing of Damage Control Orthopedic Surgery
Condition: The Precision Personal Timeline in Definitive Surgery Associated With Outcome Intervention: Procedure: Utilizing dry lab database to analyze the prognostic factors of multi-trauma patients and determine the optimal timing of definitive orthopedic operation Sponsor: China Medical University Hospital Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 27, 2023 Category: Research Source Type: clinical trials