Abnormal functional lymphoid tolerance and enhanced myeloid exocytosis are characteristics of resting and stimulated PBMCs in cystic fibrosis patients
In conclusion, we demonstrated that functional lymphoid tolerance and enhanced myeloid protease activity are key features of cystic fibrosis PBMCs. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - February 26, 2024 Category: Allergy & Immunology Source Type: research
SPLUNC1 as a biomarker of pulmonary exacerbations in children with cystic fibrosis
Cystic fibrosis (CF) is an autosomal recessive multiorgan disease that in the lung leads to impaired muco-ciliary clearance, chronic inflammation as well as acute and chronic bacterial infections, resulting in progressive loss of lung function [1,2]. Acute CF pulmonary exacerbations (PEx) usually are treated with anti-infectives; oral antibiotics for mild events and intravenous (IV) antibiotics for severe PEx [3,4]. However, while there is currently no universally accepted definition of severe PEx a [5,6], PEx episodes in children with CF treated with oral antibiotics are often not associated with significant spirometry ch...
Source: Journal of Cystic Fibrosis - February 26, 2024 Category: Respiratory Medicine Authors: E. Ben-Meir, L. Perrem, M. Shaw, F. Ratjen, H. Grasemann Tags: Original Article Source Type: research
A case report of pancreatic exocrine insufficiency in a patient with Parkinson's disease: A coincidence or is there more to it than meets the eye?
We present a case of a 60-year-old male with Parkinson's disease and persistent abdominal pain who was found to have low faecal elastase levels indicative of severe PEI. His past medical history included none of the known risk factors for PEI. After examining the literature, we report a similar pathophysiological process underlying the development of pancreatitis and Parkinson's disease which is dysfunction of the Unfolded Protein Response. We suggest further research to assess the prevalence of PEI in the population of patients with Parkinson's disease.PMID:38396339 | DOI:10.1177/14782715241234078 (Source: Journal of the ...
Source: Journal of the Royal College of Physicians of Edinburgh - February 24, 2024 Category: General Medicine Authors: David Edwards Babu Krishnan Mustafa Jalal Source Type: research
