Accidental poisoning with a plant colchicum autumnale: report of two cases - Bajramović-Omeragić L, Čalkić L, Hadžić E, Aličkovič I.
Colchicine poisonings are serious and highly fatal conditions that occur as a result of food poisoning from plants that contain this alkaloid or overdose with drug containing colchicine. The leaves of edible wild garlic because of their similarity are ofte... (Source: SafetyLit)
Source: SafetyLit - January 23, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news
Gout: Colchicine Linked to Reduced CV RiskGout: Colchicine Linked to Reduced CV Risk
Colchicine use was associated with a 49% lower risk for cardiovascular events and a 73% reduction in all-cause mortality in patients with gout. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 22, 2016 Category: Consumer Health News Tags: Rheumatology News Source Type: news
Could Old Gout Drug Offer New CV Benefits? (CME/CE)
(MedPage Today) -- Colchicine use was associated with fewer cardiovascular events and lower all-cause mortality (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - November 20, 2015 Category: Cardiology Source Type: news
Gout: Sleep apnea may raise your risk
Gout is the most common type of inflammatory arthritis and affects more than 8 million adults. Men are at a higher risk than women. And according to a new study, your risk for gout also climbs if you suffer from sleep apnea, a condition where your breathing repeatedly pauses while you sleep.
What exactly is gout?
Gout is triggered by the crystallization of uric acid within the joints. It happens like this: Your body produces uric acid from breaking down purines, a natural waste product of living cells. Normally, uric acid is dissolved in your blood and passes through your kidneys into your urine.
However, sometimes your bo...
Source: New Harvard Health Information - November 17, 2015 Category: Consumer Health News Authors: Matthew Solan Tags: Arthritis Health Sleep gout sleep apnea Source Type: news
Colchicine in acute gout: high-dose or low-dose or no-dose?
3.5 out of 5 stars
Does Colchicine Improve Pain in an Acute Gout Flare? Turner J, Cooper D. Ann Emerg Med 2015 sep;66:260-1.
Reference
The 7th edition of Tintinalli’s Emergency Medicine (2011) has this to say about using colchicine to treat gout:
Oral colchicine is typically administered in a dose of 0.6 milligrams/h until intolerable side effects (vomiting or diarrhea) or efficacy ensues.
This “typical” dosing schedule goes back decades, and even when I was a medical student who didn’t know an Ewald tube from an Ewok it never made sense to me. The instructions might as well have been “Take ...
Source: The Poison Review - September 11, 2015 Category: Toxicology Authors: Leon Tags: Medical acute gout adverse events cochrane review colchicine toxicity dosing Source Type: news
Case report: use of ECMO in colchicine poisoning
Colchicum autumnale (Autumn crocus)
3.5 out of 5 stars
Extracorporeal life support in the treatment of colchicine poisoning. Boisramé-Helms J et al. Clin Toxicol 2015;53:827-829.
Abstract
Colchicine toxicity occurs roughly in 3 phases. During the initial 24 hours, severe gastrointestinal symptoms — nausea, vomiting, and diarrhea — can cause hypotension and shock if fluid losses are not adequately replaced. During the second phase, severe toxicity can manifest with pancytopenia, sepsis, rhabdomyolysis, and renal failure. In addition, within days after ingestion, patients can develop cardiogenic shock and sudden cardia...
Source: The Poison Review - September 11, 2015 Category: Toxicology Authors: Leon Tags: Medical autumn crocus colchicine poisoning colchicum autumnale ECLS ECMO extracorporeal life support extracorporeal membrane oxygenation Source Type: news
Lupus Pericarditis Yields to Gout Drug (CME/CE)
(MedPage Today) -- Colchicine resolved pericarditis in a small French study of lupus patients. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - July 24, 2015 Category: Cardiology Source Type: news
A potentially fatal intoxication with colchicine - Boonstra JJ, Kan AA, de Vries I, Deneer VH, Meinders AJ.
BACKGROUND: Approximately ten times a year the Dutch National Poisons Information Centre (NVIC) is consulted regarding a colchicine intoxication or overdose. CASE DESCRIPTION: An 18-year old woman was admitted to the intensive care unit after a suicide att... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - March 28, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news
'Generic' Colchicine to Hit Market
(MedPage Today) -- May provide some price relief for gout patients. (Source: MedPage Today Emergency Medicine)
Source: MedPage Today Emergency Medicine - January 12, 2015 Category: Emergency Medicine Source Type: news
Mitigare (Colchicine Capsules) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - October 20, 2014 Category: Drugs & Pharmacology Source Type: news
Colchicine 'Useless' for Postop Pericardial Effusion: POPE-2Colchicine 'Useless' for Postop Pericardial Effusion: POPE-2
In yet another trial, colchicine did not reduce complications after cardiac surgery; specifically, the drug failed to decrease postoperative pericardial effusion volume or prevent cardiac tamponade. Heartwire (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 31, 2014 Category: Consumer Health News Tags: Cardiology News Source Type: news
ESC: Gout Drug Gets Thumbs Down in Heart Surgery
BARCELONA (MedPage Today) -- Findings from two trials suggested the gout drug colchicine may not be all that useful for heart surgery patients, researchers said here. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - August 30, 2014 Category: Cardiology Source Type: news
ESC: Gout Drug Little Help in Heart Surgery (CME/CE)
BARCELONA (MedPage Today) -- Giving the gout drug colchicine perioperatively to cardiac surgery patients reduced the incidence of postpericardiotomy syndrome, but didn't protect against later atrial fibrillation or pericardial/pleural effusion, researchers reported here. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - August 30, 2014 Category: Cardiology Source Type: news
COPPS-2: Colchicine Stops Postop Pericarditis, Troubles GutCOPPS-2: Colchicine Stops Postop Pericarditis, Troubles Gut
In COPPS-2, patients taking colchicine had a high rate of adverse GI events, and this likely explains why there was no overall benefit in preventing AF after cardiac surgery; but it was effective for pericarditis of postpericardiotomy syndrome. Heartwire (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 30, 2014 Category: Consumer Health News Tags: Cardiology News Source Type: news
Medication shows mixed results in reducing complications from cardiac surgery
(The JAMA Network Journals) Administration of colchicine, a plant-based medication commonly used to treat gout, before and after cardiac surgery showed mixed results in reducing potential complications from this type of surgery, but it did increase the risk of gastrointestinal adverse effects, according to a study published by JAMA. The study is being released early online to coincide with its presentation at the European Society of Cardiology Congress. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 30, 2014 Category: Global & Universal Source Type: news
