Case report: use of ECMO in colchicine poisoning

Colchicum autumnale (Autumn crocus) 3.5 out of 5 stars Extracorporeal life support in the treatment of colchicine poisoning. Boisramé-Helms J et al. Clin Toxicol 2015;53:827-829. Abstract Colchicine toxicity occurs roughly in 3 phases. During the initial 24 hours, severe gastrointestinal symptoms — nausea, vomiting, and diarrhea — can cause hypotension and shock if fluid losses are not adequately replaced. During the second phase, severe toxicity can manifest with pancytopenia, sepsis, rhabdomyolysis, and renal failure. In addition, within days after ingestion, patients can develop cardiogenic shock and sudden cardiac death. This fascinating case report — from the Nouvel Hôpital Civil in Strasbourg, France — describes the use of veno-arterial extracorporeal membrane oxygenation (ECMO) as a bridge to recover in a patient with colchicine toxicity. A 68-year-old woman inadvertently ingested the Colchicum autumnale plant, thinking it was wild leek. The plant contains colchicine,  especially concentrated in the bulb and seeds. Several hours later she developed severe vomiting and diarrhea. By day 3 (phase 2) she developed shock and multi-organ failure. She was intubated and admitted to the intensive care unit. On or about day 4 (the paper is somewhat vague on the exact time course) V-A ECMO was started because of hypotension resistant to fluids and pressors, along with an ejection fraction of 5-10%. Despite an unsurprisingly...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical autumn crocus colchicine poisoning colchicum autumnale ECLS ECMO extracorporeal life support extracorporeal membrane oxygenation Source Type: news

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Publication date: Available online 20 July 2018Source: Journal of the Formosan Medical AssociationAuthor(s): Ching-Fang Chang, Kuo-Hsuan Chung
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Publication date: Available online 20 July 2018Source: American Heart JournalAuthor(s): Nuccia Morici, Fabrizio Oliva, Silvia Ajello, Miriam Stucchi, Alice Sacco, Manlio Gianni Cipriani, Michele De Bonis, Andrea Garascia, Maria Pia Gagliardone, Giulio Melisurgo, Claudio Francesco Russo, Carlo La Vecchia, Maria Frigerio, Federico PappalardoManagement of acute decompensated heart failure (ADHF) patients presenting with cardiogenic shock (CS) is not straightforward, as few data are available from clinical trials. Stabilization before left ventricle assist device (LVAD) or heart transplantation (HTx) is strongly advocated, as ...
Source: American Heart Journal - Category: Cardiology Source Type: research
CONCLUSIONS: Endoscopic treatments are highly effective for biliary complications after LDLT. Effective use of percutaneous interventions in collaboration with endoscopic treatments significantly reduces the need for surgical treatment. PMID: 30024700 [PubMed - in process]
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
Authors: de Sire R, Rizzatti G, Ingravalle F, Pizzoferrato M, Petito V, Lopetuso L, Graziani C, de Sire A, Mentella MC, Mele MC, Gasbarrini A, Scaldaferri F Abstract In recent years, there has been an increasing interest on muscle wasting, considering the reduction of quality of life and the increase of morbidity and mortality associated. Sarcopenia and cachexia represent two conditions of reduction of muscle mass, sharing several elements involved in their pathogenesis, such as systemic inflammation, impaired muscle protein synthesis, increased muscle apoptosis, mitochondrial dysfunction in skeletal muscle tissue ...
Source: Minerva Gastroenterologica e Dietologica - Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
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Source: WebMD Health - Category: Consumer Health News Source Type: news
Ruud H. Knols, Nicolas Fischer, Dario Kohlbrenner, Anastasios Manettas, Eling D. de Bruin
Source: Frontiers in Physiology - Category: Physiology Source Type: research
See something of interest? Please share our postings with colleagues in your institutions! Spotlight The MAReport: Check out the Spring 2018 issue of the MAReport newsletter! This quarter, Academic Coordinator Elaina Vitale talked about using evidence-based resources to improve citations on Wikipedia, and her experience with NNLM’s first virtual Wikipedia Edit-a-thon. National Network of Libraries of Medicine News Dementia and Alzheimer’s Services @ Your Library – Midwest Matters, from GMR The next round of PubMed for Librarians begins August 29. Register for any (or all) of the PML classes to learn ...
Source: NN/LM Middle Atlantic Region Blog - Category: Databases & Libraries Authors: Tags: Weekly Postings Source Type: news
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Source: the Mail online | Health - Category: Consumer Health News Source Type: news
CONCLUSIONMany ureteral inguinal hernias reported in the literature have been on renal transplant patients, while rarely on native kidneys. This case suggests no inguinal hernia repair is routine. Awareness of this anomaly is important, to avoid ureteral injury during herniorrhaphy.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Conditions:   Liver Transplantation;   Low-weight Children;   Hyper-reduced Liver Grafts Intervention:   Procedure: Liver transplantation with hyper-reduced grafts Sponsor:   Hospital Italiano de Buenos Aires Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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