Case report: use of ECMO in colchicine poisoning

Colchicum autumnale (Autumn crocus) 3.5 out of 5 stars Extracorporeal life support in the treatment of colchicine poisoning. Boisramé-Helms J et al. Clin Toxicol 2015;53:827-829. Abstract Colchicine toxicity occurs roughly in 3 phases. During the initial 24 hours, severe gastrointestinal symptoms — nausea, vomiting, and diarrhea — can cause hypotension and shock if fluid losses are not adequately replaced. During the second phase, severe toxicity can manifest with pancytopenia, sepsis, rhabdomyolysis, and renal failure. In addition, within days after ingestion, patients can develop cardiogenic shock and sudden cardiac death. This fascinating case report — from the Nouvel Hôpital Civil in Strasbourg, France — describes the use of veno-arterial extracorporeal membrane oxygenation (ECMO) as a bridge to recover in a patient with colchicine toxicity. A 68-year-old woman inadvertently ingested the Colchicum autumnale plant, thinking it was wild leek. The plant contains colchicine,  especially concentrated in the bulb and seeds. Several hours later she developed severe vomiting and diarrhea. By day 3 (phase 2) she developed shock and multi-organ failure. She was intubated and admitted to the intensive care unit. On or about day 4 (the paper is somewhat vague on the exact time course) V-A ECMO was started because of hypotension resistant to fluids and pressors, along with an ejection fraction of 5-10%. Despite an unsurprisingly...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical autumn crocus colchicine poisoning colchicum autumnale ECLS ECMO extracorporeal life support extracorporeal membrane oxygenation Source Type: news

Related Links:

CONCLUSION: Our first results confirm that the FMT seems to be safe, with an impact on VRE colonization over time that may help control outbreaks. PMID: 30502308 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Abstract A 46 year old lady presented three weeks after an oesophagectomy for oesophageal carcinoma with increasing breathlessness and a large left-sided pleural effusion. Computed tomography (CT) scan of her thorax, abdomen and pelvis revealed a large left-sided and small right-sided pleural effusions, a pericardial effusion, ascites and intra-abdominal lymphadenopathy. The patient underwent both pericardial and pleural fluid drainage, however, unfortunately, deteriorated despite these interventions with increasing oxygen requirements requiring nasal high flow oxygen on the Intensive Care Unit. Her pleural and pe...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Respir Med Case Rep Source Type: research
Authors: Laranjinha I, Matias P, Oliveira R, Casqueiro A, Bento MT, Carvalho AP, Adragão T, Jorge C, Bruges M, Birne R, Machado D, Weigert A Abstract INTRODUCTION:: After a kidney transplant, it is unknown whether the maintenance of a functioning hemodialysis arteriovenous access could have deleterious effects on renal grafts. We hypothesize that maintaining an arteriovenous access can deviate a significant proportion of the cardiac output from the renal graft. The aim of this study was to investigate whether a temporary closure of the arteriovenous access could lead to an increase in graft perfusion. ME...
Source: The Journal of Vascular Access - Category: Surgery Tags: J Vasc Access Source Type: research
Abstract Background: Organ transplantation is considered the best treatment for end-stage organ failure. However, the lack of available organs for transplantation and the increasing number of patients waiting for transplants are primary issues facing the transplant community. Thus, developing strategies to increase the number of donors, especially for liver transplantation, has become a priority. The use of organs acquired from donors who suffered cardiac related deaths has increased the pool of potential liver donors. However, donation after cardiac death (DCD) livers increases the risk of primary graft dysfuncti...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Abstract Cadmium (Cd) causes a broad spectrum of toxicological effects to animals. Aquatic animals were more likely to accumulate Cd than terrestrial animals because of the living environment. Clearance of Cd in aquatic animals has become an important part of aquatic food safety. The present study was focused on the oxidative damage induced by Cd in the liver of grass carp Ctenopharyngodon idellus and the protective effect of vitamin E (VE) and metallothionein (MT). Grass carp were divided into four groups: the control group, Cd+phosphate-buffered saline (PBS) group, Cd+VE group, and Cd+MT group. All fish were inj...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
We describe herein an unusual case of complete rupture of the posterior papillary muscle occurring immediately after the development of MI.
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
We describe the case of a 68 year-old woman presenting with stress cardiomyopathy (SCM), with concomitant cardiogenic shock, left ventricular outflow tract obstruction and ventricular septal rupture. These complications have not simultaneously been reported in a single SCM case. The importance of early diagnosis of serial complications of SCM and utilizing mechanical circulatory support as a treatment strategy are highlighted.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 7 December 2018Source: Materials Science and Engineering: AAuthor(s): T. Mehner, I. Scharf, P. Frint, F. Schubert, B. Mašek, M.F.-X. Wagner, T. LampkeAbstractQuenching and partitioning (Q&P) treatments result in promising mechanical properties of advanced high-strength steels. However, recent studies indicate that Q&P steels are very susceptible to hydrogen embrittlement (HE). Using slow strain-rate tests, the effects of hydrogen charging in different media without and with recombination poison were investigated for Fe-0.38C-1.92Si-0.66Mn-1.39Cr in quenched and tempered as well as ...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
Abstract In recent years, consumer interest in health and health foods (e.g., dietary supplements) has increased, and the types of and market for health foods have also expanded rapidly. The safety of health foods is a significant concern in many countries. Numerous adverse events associated with the consumption of health foods have been reported. There are cases that have resulted in serious liver failure, renal failure, and death in other countries. These products may contain undeclared medical ingredients and toxic chemical compounds that are illegally and intentionally added or contain natural plant toxins. Pr...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
In this study, the transport mechanism of furosemide (FUR), which is transported by the same novel mechanism, was examined. In vitro cell permeation studies under air-interface conditions (AICs) revealed that the permeation from powders sprayed on cell monolayers was significantly higher than that under liquid-covered conditions (LCCs) from their solutions. The permeation from amorphous solid particles was faster than that from crystals. Similar results were derived from in vitro studies using an artificial membrane, with which the permeation of FUR could be examined without water. These findings clearly indicated that the...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research
More News: Cardiogenic Shock | Cardiology | Colchicine | Colcrys | Emergency Medicine | Gastroenterology | Heart | Hospitals | Intensive Care | Lung Transplant | Pancytopenia | Podcasts | Poisoning | Renal Failure | Rhabdomyolysis | Toxicology | Transplants | Websites | Wikis