Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B Trial): protocol for a multicentre phase 3 pragmatic clinical and cost-effectiveness randomised trial in the UK
Introduction
Almost all patients receiving mechanical ventilation (MV) in intensive care units (ICUs) require analgesia and sedation. The most widely used sedative drug is propofol, but there is uncertainty whether alpha2-agonists are superior. The alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B) trial aims to determine whether clonidine or dexmedetomidine (or both) are clinically and cost-effective in MV ICU patients compared with usual care.
Methods and analysis
Adult ICU patients within 48 hours of starting MV, expected to require at least 24 hours further MV, are randomised in an op...
Source: BMJ Open - December 10, 2023 Category: General Medicine Authors: Walsh, T. S., Aitken, L. M., McKenzie, C. A., Boyd, J., Macdonald, A., Giddings, A., Hope, D., Norrie, J., Weir, C., Parker, R. A., Lone, N. I., Emerson, L., Kydonaki, K., Creagh-Brown, B., Morris, S., McAuley, D. F., Dark, P., Wise, M. P., Gordon, A. C., Tags: Open access, Intensive care Source Type: research
Smoking cessation and its significant role in the Indian scenario
Monaldi Arch Chest Dis. 2023 Dec 4. doi: 10.4081/monaldi.2023.2814. Online ahead of print.ABSTRACTGiven the increased health dangers of tobacco use, particularly in developing countries, smoking cessation intervention is crucially important. The aim of this study is to determine and assess the effectiveness of a comprehensive smoking cessation intervention program, incorporating behavior modification, counseling, and pharmacologic treatments, in the context of the Indian scenario. The process of initiating smoking or tobacco cessation begins with the evaluation of the distinct stages that smokers undergo as part of their j...
Source: Monaldi Archives for Chest Disease - December 5, 2023 Category: Respiratory Medicine Authors: Raj Kumar Manoj Kumar Sukriti Raj Dileep Kumar Arisham Anil Kumar Mavi Kamal Singh Source Type: research
Pain Management Considerations in Patients Living with Both Pain Syndromes and Cardiovascular Diseases and Disorders
AbstractConcomitant pain syndromes and cardiovascular disease (CVD) and disorders are associated with significant morbidity, impaired quality of life, and neuropsychiatric disorders. There is an interplay between the mechanisms of pathophysiology of both CVD and pain syndromes. Patients with CVD (and/or disorders) as well as pain syndromes have an increased propensity for drug-drug/disease interactions. Therefore, an understanding of how to use pharmacotherapy to treat pain syndromes, in the context of patients who have diagnoses of CVD and/or disorders, is paramount to patients ’ success in achieving adequate pain contr...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 5, 2023 Category: Drugs & Pharmacology Authors: Emily E. Leppien,
Erin E. Pauling,
Eric Smith,
Brady Wisniewski,
Abigayle Carpenter,
Nicholas C. Schwier Tags: REVIEW Source Type: research
Corrigendum for: Blood Pressure Reduction Induced by Chronic Intracerebroventricular or Peroral Clonidine Administration in Rats With Salt-Dependent or Angiotensin II-Dependent Hypertension
Physiol Res. 2023 Nov 28;72(5):681.ABSTRACTList of changes: On the basis of author's request the publisher of Physiological Research decided to change the license of the article to CC BY license.PMID:38015766 (Source: Physiological Research)
Source: Physiological Research - November 28, 2023 Category: Physiology Authors: J Zicha L Řezáčová M Behuliak I Van ěčková Source Type: research
Corrigendum for: Blood Pressure Reduction Induced by Chronic Intracerebroventricular or Peroral Clonidine Administration in Rats With Salt-Dependent or Angiotensin II-Dependent Hypertension
Physiol Res. 2023 Nov 28;72(5):681.ABSTRACTList of changes: On the basis of author's request the publisher of Physiological Research decided to change the license of the article to CC BY license.PMID:38015766 (Source: Physiological Research)
Source: Physiological Research - November 28, 2023 Category: Physiology Authors: J Zicha L Řezáčová M Behuliak I Van ěčková Source Type: research
Corrigendum for: Blood Pressure Reduction Induced by Chronic Intracerebroventricular or Peroral Clonidine Administration in Rats With Salt-Dependent or Angiotensin II-Dependent Hypertension
Physiol Res. 2023 Nov 28;72(5):681.ABSTRACTList of changes: On the basis of author's request the publisher of Physiological Research decided to change the license of the article to CC BY license.PMID:38015766 (Source: Physiological Research)
Source: Physiological Research - November 28, 2023 Category: Physiology Authors: J Zicha L Řezáčová M Behuliak I Van ěčková Source Type: research
Corrigendum for: Blood Pressure Reduction Induced by Chronic Intracerebroventricular or Peroral Clonidine Administration in Rats With Salt-Dependent or Angiotensin II-Dependent Hypertension
Physiol Res. 2023 Nov 28;72(5):681.ABSTRACTList of changes: On the basis of author's request the publisher of Physiological Research decided to change the license of the article to CC BY license.PMID:38015766 (Source: Physiological Research)
Source: Physiological Research - November 28, 2023 Category: Physiology Authors: J Zicha L Řezáčová M Behuliak I Van ěčková Source Type: research
Corrigendum for: Blood Pressure Reduction Induced by Chronic Intracerebroventricular or Peroral Clonidine Administration in Rats With Salt-Dependent or Angiotensin II-Dependent Hypertension
Physiol Res. 2023 Nov 28;72(5):681.ABSTRACTList of changes: On the basis of author's request the publisher of Physiological Research decided to change the license of the article to CC BY license.PMID:38015766 (Source: Physiological Research)
Source: Physiological Research - November 28, 2023 Category: Physiology Authors: J Zicha L Řezáčová M Behuliak I Van ěčková Source Type: research
Corrigendum for: Blood Pressure Reduction Induced by Chronic Intracerebroventricular or Peroral Clonidine Administration in Rats With Salt-Dependent or Angiotensin II-Dependent Hypertension
Physiol Res. 2023 Nov 28;72(5):681.ABSTRACTList of changes: On the basis of author's request the publisher of Physiological Research decided to change the license of the article to CC BY license.PMID:38015766 (Source: Physiological Research)
Source: Physiological Research - November 28, 2023 Category: Physiology Authors: J Zicha L Řezáčová M Behuliak I Van ěčková Source Type: research
Corrigendum for: Blood Pressure Reduction Induced by Chronic Intracerebroventricular or Peroral Clonidine Administration in Rats With Salt-Dependent or Angiotensin II-Dependent Hypertension
Physiol Res. 2023 Nov 28;72(5):681.ABSTRACTList of changes: On the basis of author's request the publisher of Physiological Research decided to change the license of the article to CC BY license.PMID:38015766 (Source: Physiological Research)
Source: Physiological Research - November 28, 2023 Category: Physiology Authors: J Zicha L Řezáčová M Behuliak I Van ěčková Source Type: research
Corrigendum for: Blood Pressure Reduction Induced by Chronic Intracerebroventricular or Peroral Clonidine Administration in Rats With Salt-Dependent or Angiotensin II-Dependent Hypertension
Physiol Res. 2023 Nov 28;72(5):681.ABSTRACTList of changes: On the basis of author's request the publisher of Physiological Research decided to change the license of the article to CC BY license.PMID:38015766 (Source: Physiological Research)
Source: Physiological Research - November 28, 2023 Category: Physiology Authors: J Zicha L Řezáčová M Behuliak I Van ěčková Source Type: research
Corrigendum for: Blood Pressure Reduction Induced by Chronic Intracerebroventricular or Peroral Clonidine Administration in Rats With Salt-Dependent or Angiotensin II-Dependent Hypertension
Physiol Res. 2023 Nov 28;72(5):681.ABSTRACTList of changes: On the basis of author's request the publisher of Physiological Research decided to change the license of the article to CC BY license.PMID:38015766 (Source: Physiological Research)
Source: Physiological Research - November 28, 2023 Category: Physiology Authors: J Zicha L Řezáčová M Behuliak I Van ěčková Source Type: research
Corrigendum for: Blood Pressure Reduction Induced by Chronic Intracerebroventricular or Peroral Clonidine Administration in Rats With Salt-Dependent or Angiotensin II-Dependent Hypertension
Physiol Res. 2023 Nov 28;72(5):681.ABSTRACTList of changes: On the basis of author's request the publisher of Physiological Research decided to change the license of the article to CC BY license.PMID:38015766 (Source: Physiological Research)
Source: Physiological Research - November 28, 2023 Category: Physiology Authors: J Zicha L Řezáčová M Behuliak I Van ěčková Source Type: research
