Effects of Cilostazol on the Myocardium in an Obese Wistar Rat Model of Ischemia-Reperfusion Injury
CONCLUSION: Cilostazol has a protective effect on myocardial cells in IRI models by decreasing inflammation. The protective role of cilostazol was reduced in obese Wistar rats compared with normal-weight Wistar rats.PMID:37138441 | DOI:10.2174/1570161121666230502141044 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - May 4, 2023 Category: Drugs & Pharmacology Authors: Tolga Demir Mazlum Sahin Fatma Tugba Ilal Mert Fatma Sarac Source Type: research
Effects of Cilostazol on the Myocardium in an Obese Wistar Rat Model of Ischemia-Reperfusion Injury
CONCLUSION: Cilostazol has a protective effect on myocardial cells in IRI models by decreasing inflammation. The protective role of cilostazol was reduced in obese Wistar rats compared with normal-weight Wistar rats.PMID:37138441 | DOI:10.2174/1570161121666230502141044 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - May 4, 2023 Category: Drugs & Pharmacology Authors: Tolga Demir Mazlum Sahin Fatma Tugba Ilal Mert Fatma Sarac Source Type: research
Effects of Cilostazol on the Myocardium in an Obese Wistar Rat Model of Ischemia-Reperfusion Injury
CONCLUSION: Cilostazol has a protective effect on myocardial cells in IRI models by decreasing inflammation. The protective role of cilostazol was reduced in obese Wistar rats compared with normal-weight Wistar rats.PMID:37138441 | DOI:10.2174/1570161121666230502141044 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - May 4, 2023 Category: Drugs & Pharmacology Authors: Tolga Demir Mazlum Sahin Fatma Tugba Ilal Mert Fatma Sarac Source Type: research
Effects of Cilostazol on the Myocardium in an Obese Wistar Rat Model of Ischemia-Reperfusion Injury
CONCLUSION: Cilostazol has a protective effect on myocardial cells in IRI models by decreasing inflammation. The protective role of cilostazol was reduced in obese Wistar rats compared with normal-weight Wistar rats.PMID:37138441 | DOI:10.2174/1570161121666230502141044 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - May 4, 2023 Category: Drugs & Pharmacology Authors: Tolga Demir Mazlum Sahin Fatma Tugba Ilal Mert Fatma Sarac Source Type: research
Persistent High Pulse Pressure in Acute Non-Cardiogenic Ischemic Stroke as a Predictor of Neurological Deterioration and Recurrence of Ischemic Stroke: ADS Post-Hoc Analysis
CONCLUSIONS: High PP during the acute phase of ischemic stroke appears to be associated with ischemic stroke recurrence and neurological deterioration, particularly if PP is elevated both on admission and 24 h later after admission.PMID:37081614 | DOI:10.5551/jat.64079 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 21, 2023 Category: Cardiology Authors: Tadashi Ozawa Shigeru Fujimoto Junya Aoki Kosuke Matsuzono Kazumi Kimura Source Type: research
Cilostazol novel neuroprotective mechanism against rotenone-induced Parkinson's disease in rats: Correlation between Nrf2 and HMGB1/TLR4/PI3K/Akt/mTOR signaling
This study investigated the novel neuroprotective effect of cilostazol on rotenone-intoxicated rats focusing on the HMGB1/TLR4 axis, erythroid-related factor 2 (Nrf2)/hemeoxygenase-1 (HO-1), and phosphoinositide 3-kinase (PI3K)/Protein kinase B (Akt)/the mammalian target of rapamycin (mTOR) pathway. The aim is extended to correlate the Nrf2 expression with all assessed parameters as promising therapeutic targets for neuroprotection.MAIN METHODS: Our experiment was designed as follows: vehicle group, cilostazol group, rotenone group (1.5 mg/kg, s.c), and the rotenone pretreated with cilostazol (50 mg/kg, p.o.) group. Eleven...
Source: International Immunopharmacology - April 4, 2023 Category: Allergy & Immunology Authors: Rehab M El-Sayed Ahmed M Abdelaziz Hala F Zaki Nora O Abdel Rasheed Source Type: research
Cilostazol novel neuroprotective mechanism against rotenone-induced Parkinson's disease in rats: Correlation between Nrf2 and HMGB1/TLR4/PI3K/Akt/mTOR signaling
This study investigated the novel neuroprotective effect of cilostazol on rotenone-intoxicated rats focusing on the HMGB1/TLR4 axis, erythroid-related factor 2 (Nrf2)/hemeoxygenase-1 (HO-1), and phosphoinositide 3-kinase (PI3K)/Protein kinase B (Akt)/the mammalian target of rapamycin (mTOR) pathway. The aim is extended to correlate the Nrf2 expression with all assessed parameters as promising therapeutic targets for neuroprotection.MAIN METHODS: Our experiment was designed as follows: vehicle group, cilostazol group, rotenone group (1.5 mg/kg, s.c), and the rotenone pretreated with cilostazol (50 mg/kg, p.o.) group. Eleven...
Source: International Immunopharmacology - April 4, 2023 Category: Allergy & Immunology Authors: Rehab M El-Sayed Ahmed M Abdelaziz Hala F Zaki Nora O Abdel Rasheed Source Type: research
The effect of cilostazol on the platelet-derived growth factor-beta/beta isoform reduction on venous hyperplasia in an experimental balloon-induced injury model
CONCLUSIONS: Cilostazol induced a significant reduction of IH caused by barotrauma in the venous endothelium, which correlates with decrease in the PDGF-BB in serum. This could be attributed to the pharmacologic effect on PDGFR expression.PMID:36911886 | DOI:10.1177/17085381231162160 (Source: Vascular)
Source: Vascular - March 13, 2023 Category: Surgery Authors: Hugo Laparra-Escare ño Alette Ortega-G ómez Alejandro Zentella-Dehesa Joaquin Manzo-Merino Carlos Acxel Vergara-Ascencio Maria Del Carmen Antu ñano-Blanco Jose Roberto Lopez-Santacruz Eduardo Esteban Montalvo-Jave Javier E Anaya-Ayala Rodrigo Lozano-Co Source Type: research
The effect of cilostazol on the platelet-derived growth factor-beta/beta isoform reduction on venous hyperplasia in an experimental balloon-induced injury model
CONCLUSIONS: Cilostazol induced a significant reduction of IH caused by barotrauma in the venous endothelium, which correlates with decrease in the PDGF-BB in serum. This could be attributed to the pharmacologic effect on PDGFR expression.PMID:36911886 | DOI:10.1177/17085381231162160 (Source: Vascular)
Source: Vascular - March 13, 2023 Category: Surgery Authors: Hugo Laparra-Escare ño Alette Ortega-G ómez Alejandro Zentella-Dehesa Joaquin Manzo-Merino Carlos Acxel Vergara-Ascencio Maria Del Carmen Antu ñano-Blanco Jose Roberto Lopez-Santacruz Eduardo Esteban Montalvo-Jave Javier E Anaya-Ayala Rodrigo Lozano-Co Source Type: research
Intermittent treatment with Apremilast, a phosphodiesterase-4 inhibitor, ameliorates Alzheimer's-like pathology and symptoms through multiple targeting actions in aged T2D rats
CONCLUSION: Our findings demonstrate that intermittent treatment with Apre can enhance cognitive function in HF/HFr/l-STZ rats which may be related to decreased pro-inflammatory cytokines, oxidative stress, insulin resistance and GSK-3β.PMID:36848793 | DOI:10.1016/j.intimp.2023.109927 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 27, 2023 Category: Allergy & Immunology Authors: Adel A Gomaa Hanan S M Farghaly Asmaa M Ahmed Fahmy K Hemida Source Type: research
Intermittent treatment with Apremilast, a phosphodiesterase-4 inhibitor, ameliorates Alzheimer's-like pathology and symptoms through multiple targeting actions in aged T2D rats
CONCLUSION: Our findings demonstrate that intermittent treatment with Apre can enhance cognitive function in HF/HFr/l-STZ rats which may be related to decreased pro-inflammatory cytokines, oxidative stress, insulin resistance and GSK-3β.PMID:36848793 | DOI:10.1016/j.intimp.2023.109927 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 27, 2023 Category: Allergy & Immunology Authors: Adel A Gomaa Hanan S M Farghaly Asmaa M Ahmed Fahmy K Hemida Source Type: research
Intermittent treatment with Apremilast, a phosphodiesterase-4 inhibitor, ameliorates Alzheimer's-like pathology and symptoms through multiple targeting actions in aged T2D rats
CONCLUSION: Our findings demonstrate that intermittent treatment with Apre can enhance cognitive function in HF/HFr/l-STZ rats which may be related to decreased pro-inflammatory cytokines, oxidative stress, insulin resistance and GSK-3β.PMID:36848793 | DOI:10.1016/j.intimp.2023.109927 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 27, 2023 Category: Allergy & Immunology Authors: Adel A Gomaa Hanan S M Farghaly Asmaa M Ahmed Fahmy K Hemida Source Type: research
Do Patients With Arterial Occlusive Disease of Different Etiologies Benefit Equally From Cilostazol?
CONCLUSION: Patients with nonatherosclerotic arterial occlusive disease also benefit from cilostazol, but patients with Buerger disease or diabetic angiopathy seem to benefit less. Combining cilostazol with anticoagulant or antiaggregant agents and closer monitoring of these patients may produce better results.PMID:36763036 | DOI:10.14503/THIJ-21-7747 (Source: Atherosclerosis)
Source: Atherosclerosis - February 10, 2023 Category: Cardiology Authors: Burak Can Depboylu Serkan Yazman Bugra Harmandar Muruvvet Funda Tetik Hande Istar Kadir Arslan Gokhan Ilhan Source Type: research
