Effect of Cilostazol on Preventing Paclitaxel ‐Induced Neuropathy in Patients with Breast Cancer: A Randomized Controlled Trial
ConclusionAdjunctive use of cilostazol may be considered as a novel option that might reduce the incidence of paclitaxel-induced peripheral neuropathy and improve the patients ’ QoL. Future larger clinical trials are warranted to confirm these findings. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 18, 2023 Category: Drugs & Pharmacology Authors: Esraa A. Haroun,
Noha O. Mansour,
Ahmed Eltantawy,
Mohamed E. E. Shams Tags: RESEARCH ARTICLE Source Type: research
Inhibitory Effects of Aspirin and Cilostazol on Intracellular Ca < sup > 2+ < /sup > Mobilization and Aggregation in Thrombin-activated Human Platelets
J Med Invest. 2023;70(1.2):94-100. doi: 10.2152/jmi.70.94.ABSTRACTPlatelets play an important role in physiological hemostatic mechanisms. In contrast, platelet activation has been implicated in pathological conditions, such as atherosclerosis, angiogenesis, and inflammation. Thrombin is considered to be of particular pathological importance as a platelet-activating substance, and thrombin-activated platelets are detected in the blood of patients with advanced occlusive arterial disease. Ca2+ acts as a second messenger in platelet activation, and the regulation of intracellular Ca2+ concentrations ([Ca2+]i) is important fo...
Source: Journal of Medical Investigation - May 10, 2023 Category: General Medicine Authors: Atsumi Sone Kensaku Aki Toshiyuki Yasui Eiji Hosoi Source Type: research
Inhibitory Effects of Aspirin and Cilostazol on Intracellular Ca < sup > 2+ < /sup > Mobilization and Aggregation in Thrombin-activated Human Platelets
J Med Invest. 2023;70(1.2):94-100. doi: 10.2152/jmi.70.94.ABSTRACTPlatelets play an important role in physiological hemostatic mechanisms. In contrast, platelet activation has been implicated in pathological conditions, such as atherosclerosis, angiogenesis, and inflammation. Thrombin is considered to be of particular pathological importance as a platelet-activating substance, and thrombin-activated platelets are detected in the blood of patients with advanced occlusive arterial disease. Ca2+ acts as a second messenger in platelet activation, and the regulation of intracellular Ca2+ concentrations ([Ca2+]i) is important fo...
Source: Atherosclerosis - May 10, 2023 Category: Cardiology Authors: Atsumi Sone Kensaku Aki Toshiyuki Yasui Eiji Hosoi Source Type: research
Inhibitory Effects of Aspirin and Cilostazol on Intracellular Ca < sup > 2+ < /sup > Mobilization and Aggregation in Thrombin-activated Human Platelets
J Med Invest. 2023;70(1.2):94-100. doi: 10.2152/jmi.70.94.ABSTRACTPlatelets play an important role in physiological hemostatic mechanisms. In contrast, platelet activation has been implicated in pathological conditions, such as atherosclerosis, angiogenesis, and inflammation. Thrombin is considered to be of particular pathological importance as a platelet-activating substance, and thrombin-activated platelets are detected in the blood of patients with advanced occlusive arterial disease. Ca2+ acts as a second messenger in platelet activation, and the regulation of intracellular Ca2+ concentrations ([Ca2+]i) is important fo...
Source: Journal of Medical Investigation - May 10, 2023 Category: General Medicine Authors: Atsumi Sone Kensaku Aki Toshiyuki Yasui Eiji Hosoi Source Type: research
