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Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Oral Bacteria and Age-Related Airway Inflammation
Researchers have in the past proposed links between oral bacteria and chronic inflammation, particularly in the heart and brain, proposing that bacterial toxins and bacteria themselves enter the bloodstream via damaged gums. This undoubtedly happens, but supporting data is mixed when it comes to the question of whether or not this has a meaningful effect size in comparison to other inflammatory mechanisms and contributions to age-related disease. Here, a different route for bacteria is proposed: passage into the airways and lungs, a possibly explanation as why gum disease and respiratory mortality are correlated in older p...
Source: Fight Aging! - November 29, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

End-of-Life Care: ER Doctor Answers Our Questions
Emergency room doctor Kevin Haselhorst had an epiphany while he tried valiantly to save an elderly man who’d been through one-too-many traumas. His book, “Wishes To Die For: A Caregiver’s Guide to Advance Care Directives,” was the first step toward a new advocacy. Dr. Haselhorst continues to work toward helping people understand the importance of healthcare directives and the ability to make their own decisions about end-of-life care. Curious about more of Dr. Haselhorst’s views, the Candid Caregiver contacted him through email for the following interview. ...Carol: Dr. Haselhorst, your book starts o...
Source: Minding Our Elders - November 27, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Highly Sensitive Motion Sensors from Xandar Kardian Anticipate Critical Health Incidents
Timely prediction is key to saving both lives and money in the health care system. I recently talked to Sam Yang, managing director and cofounder of Xandar Kardian, about their motion sensor called XK300 that can tip off clinicians to oncoming emergencies in patients suffering from COVID-19, heart failure, COPD, pneumonia, asthma, and more. The […] (Source: EMR and HIPAA)
Source: EMR and HIPAA - November 9, 2021 Category: Information Technology Authors: Andy Oram Tags: AI/Machine Learning Analytics/Big Data Healthcare IT Hospital - Health System Telemedicine and Remote Monitoring Biometric Devices Merck Motion Sensors Sam Yang Vital Signs Xandar Kardian XK300 Motion Sensor Source Type: blogs

#Healthin2Point00, Episode 240 | Tebra, Notable, Wellinks, Aktiia, and Enlace Health
Today on Health in 2 Point 00, Jess and I talk briefly about Frontiers Health – frontiers.health – a digital health company with a deep therapeutics focus. Kareo and Patient Pop merge to form Tebra and get $65 million dollars from a PE firm. A notable raise from Notable, $100 million in a Series B brings to total up to $119 million. Wellinks gets $25 million in a Series C in the COPD space. Constant Blood Pressure monitoring company Aktiia gets $17.5 million, bringing their total up to $28 million. Aver Inc. rebrands, becoming Enlace Health, and raises 58 million dollars bringing their total up to $111 million....
Source: The Health Care Blog - November 4, 2021 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health in 2 Point 00 Health Tech Uncategorized Cox.inc Enlace Health 2.0 Jessica DaMassa Kareo Matthew Holt Notable patient pop Tebra Source Type: blogs

Health Insurance is a Stumbling Block in Many Patients ’ Thinking
By HANS DUVEFELT I have a patient with no health insurance but a brand new Mercedes. He says he can’t afford health insurance. He cringes at the cost of his medications and our office visit charges. His car cost a lot of money and I know that authorized Mercedes dealers charge around $140/hour for their technicians’ (not mere mechanics) time. A routine service costs several hundred dollars, which he seems more okay with than the cost of his own healthcare visits. His new Mercedes is under warranty, but his body is not. He is risking financial disaster if he gets seriously ill with no insurance coverage. I have...
Source: The Health Care Blog - August 27, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Patients Physicians Primary Care Hans Duvefelt Health insurance Source Type: blogs

How much ST depression in V2 and V3 is acceptable before you suspect ischemia?
A 60-something woman with h/o bioprosthetic MV replacement and COPD, who is not on anticoagulants (bioprosthetic valves generally do not require anticoagulation), presented after 14 hours of left sided chest pain with radiation down left arm. It woke her up at 0200. She states that now it is worse with deep inspiration and associated with SOB. Here is her triage ECG:What do you think?Here I magnify leads V2-V4:There is almost 1 mm ST depression at the J-point, relative to QRS onset, in lead V3. We don ' t really know about lead V2 because it was placed too high (Negative P-wave shows that it wa...
Source: Dr. Smith's ECG Blog - August 3, 2021 Category: Cardiology Authors: Steve Smith Source Type: blogs

Google ’ s Masterplan for Healthcare
With 7% of Google searches – or 70,000 per minute – being health-related, it was only a matter of time before the search giant aimed to be a healthcare giant. Google hasn’t been particularly shy at expressing these ambitions either. It purchased Fitbit for $2.1 billion and had a dedicated healthcare offshoot from its A.I. branch, Deepmind. In this new article series exploring the latest moves by tech giants into healthcare, we will look at recent developments coming from Google. Previous entries looked at the moves of Google’s competitors Amazon and Apple, and provided insights into the trends that those companies ...
Source: The Medical Futurist - July 27, 2021 Category: Information Technology Authors: berci.mesko Tags: Artificial Intelligence in Medicine Digital Health Research Future of Medicine Future of Pharma Genomics Health Sensors & Trackers Portable Medical Diagnostics Security & Privacy AI genetics google Healthcare Innovation technolog Source Type: blogs

The Road to Low Cost Universal Cells and Tissues, For Transplantation into Any Patient
An area of intense interest in the academic and biotechnology communities is the development of cells that do not provoke an immune response due to mismatch of cell surface receptors. As a general rule, cells from one individual are rejected by any other individual. It is possible to minimize this outcome by eliminating MHC receptors, but there are other complex interactions between cell surface chemistry and portions of the immune system that can still act as a barrier to transplantation. A number of groups have developed approaches to address specific parts of this problem space, but no one winner has yet emerged. At the...
Source: Fight Aging! - July 20, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins." Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Details on the Failed Phase 3 Trial of the resTORbio mTORC1 Inhibitor
The short version of the story regarding the failure of resTORbio's phase 3 trial of an mTORC1 inhibitor targeting immune function and influenza infection in old people is that the FDA forced a last minute change of the phase 3 endpoint from the phase 2 endpoint of a reduction in clinically confirmed infections to a more nebulous outcome of whether or not people reported feeling better. Which is far from the worst offense that FDA staff have committed in the course of hindering the adoption of new medical technologies, but it is illustrative of the obstacle that regulators pose. We can all speculate as to what was going on...
Source: Fight Aging! - June 16, 2021 Category: Research Authors: Reason Tags: Politics and Legislation Source Type: blogs

Case of the Week 641
This week ' s case was generously donated by Dr. Alexander Fenwick and includes some beautiful images. The following objects were seen in a sputum specimen from a patient living in Eastern Kentucky. This patient was receiving corticosteroid therapy for poorly-controlled COPD. Identification?Gram stain (10x and 100x magnification)Wet mount: (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - June 1, 2021 Category: Parasitology Source Type: blogs

Fight Aging! Newsletter, May 24th 2021
In conclusion, we showed that addition of resistance exercise training, but not dietary EAAs, to the myostatin inhibition further increased muscle mass through the attenuation of muscle protein breakdown with proportionate improvements in muscle strength. Interestingly, addition of dietary EAAs to the myostatin inhibition with or without resistance exercise training improved muscle quality. Thus, dissection of the underlying mechanisms behind the combined positive effect of dietary EAAs and resistance exercise training on muscle mass and quality can shed light on the discovery of effective therapeutics against muscle wasti...
Source: Fight Aging! - May 23, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Critiquing the Hallmarks of Aging
The biggest problem I see with the Hallmarks of Aging paper is not really the fault of its authors, but rather that a sizable part of the research community now takes that list of aging associated mechanisms as a guide to points of intervention in aging. Unlike the SENS view of aging, a list of mechanisms in aging that preceded the Hallmarks paper by more than a decade, the Hallmarks were not established to be a list of root causes of aging, and were never intended to be taken as such. In the case of SENS, wherein a great deal of thought has gone into identifying mechanisms that are root causes of aging, one can pro...
Source: Fight Aging! - May 20, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Kaia Health Raises $75 Million Series C to Optimize MSK and COPD Care in the U.S. and Europe
Kaia Health is announcing a $75 million Series C round (total raised to date: $125 million) to expand clinical capabilities and transform the treatment path for Musculoskeletal (MSK) and Chronic obstructive pulmonary disease (COPD) care in the U.S. and Europe. Fundraising was led by an unnamed leading growth equity fund with support from existing investors, […] (Source: EMR and HIPAA)
Source: EMR and HIPAA - April 28, 2021 Category: Information Technology Authors: Healthcare IT News Tags: Analytics/Big Data Health IT Company Healthcare IT 3VC A Round Capital Balderton Capital capital300 COPD Care Digital Therapeutics Digital Therapeutics Funding Eurazeo Health IT Funding Heartcore Capital Kaia Gateway Kaia Healt Source Type: blogs