Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A call for LGBTQ+ inclusion in medicine ’ s definition of “ underrepresented ”
In an impromptu listing of all the diseases his children had, I never would have guessed that the next word to come out of my attending’s mouth was “gay.” As an LGBTQ+ medical student with scars on my chest to prove it, this encounter only added to the collection of instances where I felt the
Read more…
A call for LGBTQ+ inclusion in medicine’s definition of “underrepresented” originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 19, 2024 Category: General Medicine Authors: Mel Ebeling and Cortlyn Brown, MD Tags: Education Medical school Source Type: blogs
Genetic Associations with Longevity are Stronger in Women
In this study, we discovered that genetic associations with longevity are on average stronger in females than in males through bio-demographic analyses of genome-wide association studies (GWAS) dataset of 2178 centenarians and 2299 middle-age controls of Chinese Longitudinal Healthy Longevity Study (CLHLS). This discovery is replicated across North and South regions of China, and is further confirmed by North-South discovery/replication analyses of different and independent datasets of Chinese healthy aging candidate genes with CLHLS participants who are not in CLHLS GWAS, including 2972 centenarians and 1992 middle-age co...
Source: Fight Aging! - January 19, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
This Way Of Reading Leads To 8 Times Better Understanding (M)
The study's results are particularly important for children, but probably hold for those of us now past the first flush of youth. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - January 18, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Learning subscribers-only Source Type: blogs
A Step-By-Step Guide To Measuring Sleep
This study provides indirect evidence that the genes predisposing adults to insomnia may also contribute to poor sleep from toddlerhood through adolescence, suggesting the existence of a ‘poor sleeper’ trait that persists throughout a lifetime.
Regardless of our genes, we don’t learn as children how to achieve (the best possible) quality sleep nor understand what good sleep specifically means for us as individuals.
We previously have written about sleep tracking multiple times, you can also check back here for example.
Let’s quickly get over a few basic questions!
Is it fundamental to ...
Source: The Medical Futurist - January 18, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF digital health sleep tracking sleep optimization how to sleep better Source Type: blogs
Religion and morality
A commenter asks about the relationship over time between religiosity, and crime and " sexual deviance. " You got it!If you will refer to my previous post on declining religiosity in America (or just take my word for it) the trend toward fewer people claiming religious affiliation began in about 1992. What a coinkydink! That ' s exactly when the crime rate began to decline. Here are property crimes (data is from the Bureau of Justice Statistics andI cribbed it from the Wikipedia article): And whaddya know, that ' s also exactly when the homicide rate started to decline! (Note that it first started to go up sharp...
Source: Stayin' Alive - January 17, 2024 Category: American Health Source Type: blogs
Losing my religion
I ' m going to interrupt the series on medical costs for today and talk about religion. I ' m sure it won ' t come as a surprise to anyone that I am very pleased by the graph below.I took it from this Daily Kos diary about the actual meaning of " Christian " identity to Trump cultists, which is not really the main point of this post although it ' s relevant.The majority of poll respondents still say they identify as Christian, but it ' s a sharply declining majority. Furthermore, many people who say they identify as Christian do not attend church regularly. Church is for weddings and funerals and maybe Christmas and Easter...
Source: Stayin' Alive - January 15, 2024 Category: American Health Source Type: blogs
knownwell Raises $20M Series A From A16Z to Scale the First Patient-Centered Healthcare Home For Those With Overweight and Obesity
Building on This Mission, the Company is Launching an Adolescent Metabolic Health Program to Combat Rising Child Obesity Rates
knownwell, an in-person and virtual, weight-inclusive primary care and metabolic health company, today announced that it has raised a $20 million Series A funding round led by a16z with participation from existing investors including Flare Capital Partners. This brings knownwell’s total funding to $24.5 million and highlights a growing demand for weight-inclusive care companies focusing on whole-person treatment approaches to obesity beyond just short-term approaches like GLP-1 utilization organi...
Source: EMR and HIPAA - January 15, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT a16z Brooke Boyarsky Pratt Dr. Angela Fitch Flare Capital Partners Health IT Funding Health IT Fundings Health IT Investment knownwell Vineeta Agarwala Source Type: blogs
Right Heart Catheterization in Tetralogy of Fallot
With the availability of high resolution echocardiographic images and Doppler echocardiography, role of cardiac catheterization has come down in tetralogy of Fallot and other congenital heart diseases in general. Important risks for cardiac catheterization in a deeply cyanotic infant are the chance of precipitation of a cyanotic spell and thrombotic strokes due to hemoconcentration. Chance of precipitating a cyanotic spell are more when pulmonary angiography is attempted through the already narrow right ventricular outflow tract. Hemocontration is due to the diuresis following contrast angiography, which can be prevented ...
Source: Cardiophile MD - January 15, 2024 Category: Cardiology Authors: Johnson Francis Tags: Angiography and Interventions Source Type: blogs
Self-management skills we don ’ t often discuss
I’m back from my summer break (I’m in Aotearoa/New Zealand – we shut down over Christmas/New Year just like the US and UK do over July/August!), and I want to begin with a cracker of a topic: medication management!
Now I am not a prescriber. I don’t hold any ability to write prescriptions of any kind, not even exercise ;-). Yet most of the people I’ve seen in clinical practice have started their journey living with pain by being prescribed medications.
All medications have side effects, true effects (well… maybe), adverse effects, and the human factor: taking them in the way that o...
Source: HealthSkills Weblog - January 14, 2024 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Coping strategies Research Science in practice pain management self-management Therapeutic approaches Source Type: blogs
Bonus Features – January 14, 2024 – Epic Research shows telehealth results in more follow-up visits that in-office care, Elevance Health to offer smartphones to qualified Medicaid beneficiaries, plus 21 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News and Studies
Follow-up rates for telehealth and in-office visits have remained consistent since 2020, according to analysis from Epic Research. That said, telehealth visits are more likely to result in follow-ups at the 7-, ...
Source: EMR and HIPAA - January 14, 2024 Category: Information Technology Authors: Brian Eastwood Tags: Ambulatory Health IT Company Healthcare IT Hospital - Health System LTPAC Abbott Alliance for Pediatric Device Innovation American Telemedicine Association Atropos Health Butterfly Network Caregility Cedar Gate Technologies Childre Source Type: blogs
Orthostatic hypotension onset after invasive procedure?
Written by Willy FrickA man in his 70s with a history of HFrEF and sick sinus syndrome s/p dual chamber pacemaker placement was admitted for overnight observation following outpatient placement of a mitral valve clip. The procedure note indicates uncomplicated clip placement. The next morning, the following ECG was obtained.What do you think?The tracing shows sinus rhythm with PVCs and non-specific ST&T wave abnormality. But there is something more important to notice, which is the pacer spikes. They do not make sense. Some of them are in the middle of or after P waves, and there ' s even one that falls at the end...
Source: Dr. Smith's ECG Blog - January 13, 2024 Category: Cardiology Authors: Willy Frick Source Type: blogs
New Book Sketches
One of my favorite things when writing children ' s books is when my wonderful and talented illustrator,Kyra Teis, takes my notes and creates the characters and illustrations for the picture book. It ' s so exciting to see my ideas come to life, and to have the beginning artwork take shape. My next book will focus on jealousy in children in late 2024. Can ' t wait to share more. (Source: Dr. Deborah Serani)
Source: Dr. Deborah Serani - January 12, 2024 Category: Psychiatry & Psychology Tags: books children jealousy libraries parenting psychology read-aloud visits self help booksteachers wellbeing Source Type: blogs
A Rationale and Roadmap for Paralegal Clinics: Advocating for Disabled Children and Youth
Stephen A. Rosenbaum (University of California Berkeley), A Rationale and Roadmap for Paralegal Clinics: Advocating for Disabled Children and Youth (Human Rights And Legal Services For Children And Youth, 2023): The terms lay advocate, lay practitioner, legal assistant, nonlawyer, nonlawyer... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - January 12, 2024 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
How Can the Immune System Go Awry?
This post is part of a miniseries on the immune system. Be sure to check out the other posts in this series that you may have missed.
The immune system is designed to closely monitor the body for signs of intruders that may cause infection. But what happens if it malfunctions? Overactive and underactive immune systems can both have negative effects on your health.
Autoimmune Disorders
To effectively monitor the body for pathogens, the adaptive immune system has to learn what a pathogen “looks like” on a molecular level. During their development, white blood cells go through training to learn how to differe...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 8, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Injury and Illness Diseases Immunology Miniseries Infectious Diseases Microbes Sepsis Source Type: blogs
