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Treating precancers reduces breast cancer deaths
Breast cancer deaths rose through the '70s and '80s, but declined in the '90s. For nearly the past 20 years, American women have had about a 2% annual drop in the breast cancer death rate.Here is the mortality graph provided by the National Cancer Institutes SEER (Surveillance, Epidemiology and End Results) program.Though nobody wants to take the blame for the rise in breast cancer deaths in the '70s and '80s, lots of people want credit for the fall of breast cancer deaths that began in the '90s. Was it due to a reduction to the exposure of carcinogens, or to better treatment, or to earlier diagnosis? The fall in breast...
Source: Specified Life - July 13, 2014 Category: Pathologists Tags: cancer prevention cancer treatment early treatment precancer precancer treatment preneoplasia preneoplastic Source Type: blogs

Rare Cancer are Subsets of Common Cancers
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. One of the key ideas developed in the book is that each common diseases is actually an aggregate of cellular processes that are present, individually, in rare diseases. In the case of the common cancers, we can find specific rare diseases that are subsets of the common diseases. Here is an excerpt from Chapter 8: 8.3.3 Inherited syndromes that...
Source: Specified Life - July 9, 2014 Category: Pathologists Tags: cancer syndromes carcinogenesis common cancers common disease familial cancer syndromes genetic disease orphan disease orphan drugs rare cancers rare disease Source Type: blogs

Direct Assault on Advanced Stage Common Cancers Has Not Yielded Cures
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. Here is a short excerpt from Chapter 8: Though there are thousands of types of human cancer, the bulk of cancer cases in humans are accounted for by just a few, under a dozen, types of cancer. The two most commonly occurring cancers of humans are basal cell carcinoma of skin and squamous cell carcinoma of skin. Together, these two tumors account...
Source: Specified Life - July 8, 2014 Category: Pathologists Tags: advanced stage cancer cancer funding cancer priorities cancer research funding common disease cures for advanced stage cancers orphan disease orphan drugs rare disease Source Type: blogs

Invasive Micropapillary Carcinoma of the Breast
DefinitionBreast carcinoma with a prominent (pseudo) micropapillary patternDiagnostic CriteriaNumerous small pseudo-papillary clusters of cellsNo fibrovascular coresFrequent central lumen formation in clustersPeripherally located nuclei frequently bulge out with knobby appearance, "the hedgehog" tumorClusters surrounded by clear spacesOne or only a few clusters per spaceScant mucin rarely detectable in spacesSpaces surrounded by loose fibrocollagenous stromaFrequent high nuclear grade reported in some seriesFrequently has abundant eosinophilic cytoplasmFrequent lymphatic involvementOccasional psammoma bodiesAssociated DCIS...
Source: Oncopathology - March 1, 2014 Category: Pathologists Source Type: blogs

New Study Raises More Questions About the Value of Mammograms
This chart, published in British Medical Journal, shows that the breast cancer mortality of patients who underwent mammogram screening vs. those who did not is practically equal.A new, long-term study in BMJ provides perhaps the most compelling argument to date that screening mammograms may not be effective in reducing the death rate from cancer and may in fact cause harm from overtreatment in some women. The study is based on results from the Canadian National Breast Screening Study. For this research, 89,835 women ages 40 to 59 were randomly assigned to receive either annual mammograms for five years, or no mammograms ...
Source: Our Bodies Our Blog - February 14, 2014 Category: Health Medicine and Bioethics Commentators Authors: Rachel Tags: Breast Cancer Research & Studies Source Type: blogs

New nanopharmaceutical may help overcome resistance to specific anticancer drugs
Conclusions: Results generated through this translational research plan suggest that CRLX101 can overcome HIF-1α-mediated acquired resistance to antiangiogenic drugs, assisting the use of CRLX101 in combination with antiangiogenic medicines as an exciting new paradigm for the treatment of cancer. Related Posts:Cleveland Clinic’s preventive breast cancer vaccine…Harvard Stem Cell Institute publishes initial clinical trialImportant advance in the fight against skin cancerNew IBS treatment shows possible in Phase 2 researchNew blood test could help millions of patients with&hellip...
Source: My Irritable Bowel Syndrome Story - October 21, 2013 Category: Other Conditions Authors: Ken Tags: IBS News Source Type: blogs

Esteya System for Skin Cancer Treatment Gets FDA 510(k) Clearance (VIDEO)
Nucletron, an Elekta company based in Atlanta, GA, has received FDA clearance for the Esteya electronic brachytherapy system for treating patients with skin cancer. According to the CDC, skin cancer is the most common form of cancer in the United States, and each year there are more new cases of skin cancer than the combined incidence of cancers of the breast, prostate, lung and colon. Though surgery is the main treatment strategy for skin cancer, High Dose Rate (HDR) brachytherapy for nonmelanomatous skin cancer, such as basal cell carcinoma and squamous cell carcinoma, provides an alternative treatment option. Electronic...
Source: Medgadget - October 4, 2013 Category: Technology Consultants Authors: Gaurav Krishnamurthy Tags: Dermatology Oncology Plastic Surgery Source Type: blogs

Most common cause of death in older women
: a) Uterine malignancy b) Carcinoma breast c) Cardiovascular disease d) None of the above Correct answer: c) Cardiovascular disease (Source: Cardiophile MD)
Source: Cardiophile MD - September 25, 2013 Category: Cardiology Authors: Prof. Dr. Johnson Francis MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs

Shannon’s Story: Confronting Ovarian Cancer
My name is Shannon. I am from Charlotte, NC. I am married. In July of 2009, I had just returned from my dream vacation to France. Not even a month later, following a few trips to the gynecologist with complaints of abdominal pain, I was sitting in the office of a gynecologic oncologist. I had never even heard those words used in a sentence. I was being prepped for surgery to remove a cyst. One week later, I was diagnosed with Stage IIa clear cell carcinoma, a form of ovarian cancer considered rare in younger women. Within two weeks of being diagnosed, I had a radical hysterectomy and a few weeks ...
Source: Disruptive Women in Health Care - September 12, 2013 Category: Health Medicine and Bioethics Commentators Authors: dw at disruptivewomen.net Tags: Cancer Caregiving Women's Health Source Type: blogs

Top stories in health and medicine, September 6, 2013
From MedPage Today: MRI No Help for Breast Cancer Recurrence After DCIS. Perioperative MRI did not reduce the risk of breast cancer recurrence after treatment of ductal carcinoma in situ (DCIS). Warnings on Packs Deter Kids From Smoking. The addition of graphic warnings on cigarette packs were more likely to discourage teens from smoking than when warnings were text-only, but did little to dissuade teens who were already regular smokers. Antidepressants Have No Effect on Bone Loss. The use of selective serotonin reuptake inhibitors (SSRIs) or tricyclic antidepressants among women in midlife didn’t lead to a greater...
Source: Kevin, M.D. - Medical Weblog - September 6, 2013 Category: Family Physicians Tags: News Cancer Endocrinology Pediatrics Source Type: blogs

Lets redefine cancer
The question has arisen as to how to redefine cancer. A scientific panel states we are using a 19th century definition in the 21st century. The issue is should some precancerous conditions be redefined with out the use of the words cancer or carcinoma."In one example, they say that some premalignant conditions, such as one that affects the breast called ductal carcinoma in situ — which many doctors agree is not cancer — should be renamed to exclude the word carcinoma. That way, patients are less frightened and less likely to seek what may be unneeded and potentially harmful treatments that can include the sur...
Source: Caroline's Breast Cancer Blog - July 30, 2013 Category: Cancer Tags: cancer diagnosis Source Type: blogs

First Person: I’ve Been Diagnosed with Ductal Carcinoma in Situ Invasive Breast Cancer
This Yahoo Contributor shares how her life has changed since recently being diagnosed with breast cancer.Contributor: Lee HansenPublished: Jun 29, 2013 (Source: Most Recent Health Wellness - Associated Content)
Source: Most Recent Health Wellness - Associated Content - June 29, 2013 Category: Other Conditions Source Type: blogs

Paget's disease if Nipple- Review
Clinical: Approximately 1%–3% of women with adenocarcinoma of the breast have Paget disease. Clinically-Paget disease has common dermatitis-like appearance, as originally described in 1874, when Sir James Paget recorded that such lesions may resemble “ordinary chronic eczema” or present as nipple erosion or ulceration. Paget disease often has a deceptively banal clinical morphology but should lead the list of differential diagnoses when evaluating unilateral lesions of the nipple–areola complex in adults. Paget disease presenting with nipple erosion. Most women with the histopathologic finding o...
Source: Oncopathology - June 28, 2013 Category: Pathologists Tags: Breast Biopsy Procedure Breast Carcinoma vs. Pulmonary Adenocarcinoma a common misdiagnosis. Source Type: blogs