What If The Pathologist Is Wrong?
And they won ' t review all the tests. This is a two part misadventure.First I was horrified by thisfirst story where two women were found to have been misdiagnosed by a pathologist at a hospital in Ireland. Their original breast cancer diagnoses were incorrect. One woman was diagnosed with DCIS in 2010 and had a mastectomy. Based on the original pathology she was not required to have any additional treatment. In 2012, to the surprise of her and her doctor, her cancer came back." Her original 2010 biopsy had shown invasive cancer but this had been missed.The hospital said this was a mistake that any pathologist could have ...
Source: Caroline's Breast Cancer Blog - February 22, 2018 Category: Cancer & Oncology Tags: breast cancer treatment cancer diagnosis medical errors pathology report Source Type: blogs
Precision Medicine and Public Health (from Precision Medicine and the Reinvention of Human Disease)
Excerpted fromPrecision Medicine and the Reinvention of Human DiseaseDespite having the most advanced healthcare technology on the planet, life expectancy in the United States is not particularly high. Citizens from most of the European countries and the highly industrialized Asian countries enjoy longer life expectancies than the United States. According to the World Health Organization, the United States ranks 31st among nations, trailing behind Greece, Chile, and Costa Rica, and barely edging out Cuba [42]. Similar rankings are reported by the US Central Intelligence Agency [43]. These findings lead us to infer that acc...
Source: Specified Life - February 6, 2018 Category: Information Technology Tags: cancer cancer vaccines precision medicine prevention public health Source Type: blogs
Precision Medicine and the Reinvention of Human Disease (Book Index)
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book ' s index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 198, 220geAcq...
Source: Specified Life - January 23, 2018 Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
Breast Implant MRI : Teaching Points
Case Report Follow up case of subpectoral silicone implant with no old scans available.MR findingsBoth breasts suggest well defined regular silicone implants in deep pectoral region with intact capsule. Subtle heterogeneity of the silicone signal at places is MR flow or interphase related with no linguine sign positivity to suggest any intra or extracapsular rupture of silicone. The contour of implant at places is depressed suggesting partial collapse (more seen in left breast implant anteriorly. Pectoral muscles appear normal. Both breast show tiny bright foci – possibly cysts with rest normal with no axillary lymp...
Source: Sumer's Radiology Site - October 9, 2017 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Why a case report being circulated by advocates doesn't show that the ketogenic diet combats cancer
In conclusion, this combined metabolic approach appears effective in treating advanced TNBC, given this patient’s complete response with a good quality of life.Now, there is one thing that is interesting here. The doses of chemotherapy used were considerably lower thanwhat is usually used, with doses decreased by at least half or more. Does this mean anything? Who knows? cPR rates for TNBC have been reported to range from 20-35%. It could mean the regimen made the chemotherapy more effective, or it could mean that this woman just happened to have a particularly chemosensitive tumor. Even if we take this case report at fa...
Source: Respectful Insolence - October 4, 2017 Category: Surgery Authors: oracknows Source Type: blogs
Why a case report being circulated by advocates doesn't show that the ketogenic diet combats cancer
In conclusion, this combined metabolic approach appears effective in treating advanced TNBC, given this patient’s complete response with a good quality of life.Now, there is one thing that is interesting here. The doses of chemotherapy used were considerably lower thanwhat is usually used, with doses decreased by at least half or more. Does this mean anything? Who knows? cPR rates for TNBC have been reported to range from 20-35%. It could mean the regimen made the chemotherapy more effective, or it could mean that this woman just happened to have a particularly chemosensitive tumor. Even if we take this case report at fa...
Source: Respectful Insolence - October 4, 2017 Category: Surgery Authors: oracknows Source Type: blogs
Fight Aging! Newsletter, June 12th 2017
In this study, we focused on two pathways of cardiomyocytes or heart cells: the Hippo pathway, which is involved in stopping renewal of adult cardiomyocytes, and the dystrophin glycoprotein complex (DGC) pathway, essential for cardiomyocyte normal functions."
Previous work had hinted that components of the DGC pathway may somehow interact with members of the Hippo pathway. The researchers genetically engineered mice to lack genes involved in one or both pathways, and then determined the ability of the heart to repair an injury. These studies showed for the first time that dystroglycan 1, a component of the DGC pathw...
Source: Fight Aging! - June 11, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing What is Known of PTEN and its Longevity Effects
The PTEN gene shows up in a number of places in aging research, and today's paper is a review of what is known of its relevance to the field. To pick a few items, PTEN appears to be involved in some of the processes and pathways that control nutrient sensing, and is thus of interest to researchers attempting to recreate the beneficial effects of calorie restriction via pharmaceuticals. It is also involved in regeneration and cancer as a governor that prevents excessive cell growth. In this context, PTEN suppression has been shown to enhance nerve regrowth in mice, but of course there are other, adverse consequences to turn...
Source: Fight Aging! - June 6, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Why You Should Get a Second Opinion on Your Mammogram
Never say no to a second opinion, especially if you ’re concerned about breast cancer. According to a new study, radiologist subspecialists can detect breast cancer in screenings that were initially deemed negative.Lead investigator, MD and her colleaguesexamined2,400 cases that took place between January 2010 and June 2014. They discovered that 11.3 percent, or 271 patients had a malignancy. Out of the 189 patients (7.9 percent) who underwent a subsequent biopsy, 24 of them were diagnosed with cancer. In the final biopsy, radiology subspecialists found 15 cases of breast cancer, 10 invasive carcinomas, and five ductal c...
Source: radRounds - June 3, 2017 Category: Radiology Authors: Julie Morse Source Type: blogs
Top Companies in Genomics
From portable genome sequencers until genetic tests revealing distant relations with Thomas Jefferson, genomics represents a fascinatingly innovative area of healthcare. As the price of genome sequencing has been in free fall for years, the start-up scene is bursting from transformative power. Let’s look at some of the most amazing ventures in genomics!
The amazing journey of genome sequencing
Genome sequencing has been on an amazing scientific as well as economic journey for the last three decades. The Human Genome Project began in 1990 with the aim of mapping the whole structure of the human genome and sequencing it. ...
Source: The Medical Futurist - May 30, 2017 Category: Information Technology Authors: nora Tags: Genomics Personalized Medicine AI artificial intelligence bioinformatics cancer DNA dna testing DTC gc3 genetic disorders genetics genome sequencing personal genomics precision medicine Source Type: blogs
Futura Genetics Analyzed my Genome – Genetic Test Review
Through the rise of personalized medicine, carrying out genome tests at home became feasible. With a PhD in genomics, I’m always curious and excited to try out novelties in my field. This time, Futura Genetics offered me a genetic test, and I was happy to give it a try.
Genome Testing is Sexy
Genome tests have been in the spotlight for years. Patients have been able to order such tests online with 23andme, Navigenics or Pathway Genomics since 2005, 2006 and 2007. The basic assumption is that anyone can order a test from home and learn about their risks for certain medical conditions, and what lifestyle choices they sho...
Source: The Medical Futurist - September 20, 2016 Category: Information Technology Authors: nora Tags: Genomics Futura Genetics future gc3 Genetic testing Genome Innovation Source Type: blogs
Palliative Chemotherapy: An Oxymoron
By Rebecca Gagne HendersonI was inspired to write this after reading the series of posts on Pallimed titled “Against Euphemisms” by Drew Rosielle. At its very best, the term “Palliative Chemotherapy” is an oxymoron. At its worst, it is a treatment that robs the patient and family of quality of life and valuable time may have been spent doing the things that are important to them.As a palliative consultant on a campus which does not house a cancer center my referrals typically come from hospitalist attending physicians rather than oncologists. I cannot begin to tell you the number of conversations I have had through...
Source: Pallimed: A Hospice and Palliative Medicine Blog - August 1, 2016 Category: Palliative Care Tags: cancer chemotherapy euphamisms gagne henderson palliative rebecca Source Type: blogs
Wisdom…
…the quality of having experience, knowledge, and good judgment.
I read today a collection of words that exude wisdom. I share it with you because the purpose of this blog is to do create value through education.
Peggy Girshman was an award-winning health journalist. When ill with a life-limiting illness, she wrote her own eulogy. NPR published it today after her death.
Must-read is an overused phrase, but it modifies perfectly her words. Here are a few excerpts, with my thoughts.
Work-Life Balance: Though Girshman wished she could have worked longer, “to convince someone I was right,” she also wished she...
Source: Dr John M - May 9, 2016 Category: Cardiology Authors: Dr John Source Type: blogs
Are we practicing medical misogyny?
When it comes to cancer, I’m neither physician nor patient, nor even a policy expert. But being both a critical thinker and a feminist, I’m struck by what the juxtaposition of two seemingly unrelated new oncology studies, published in highly respected medical journals a month apart, can tell us about how gender shapes the way we perceive (or misperceive) illness, and the impact that has on patients’ well-being.
On April 14, JAMA Oncology published “Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma.” Although the title may be nearly impenetrable to the...
Source: Kevin, M.D. - Medical Weblog - May 6, 2016 Category: Journals (General) Authors: Lois Leveen, PhD Tags: Conditions Cancer Source Type: blogs
