Cancer, Autoimmunity and Immunology 2019 (Day 1)
This event will bring together basic research scientists, clinical research scientists and front line physicians who will be discussing the latest immunotherapy breakthroughs in the context or initiation of autoimmune disease. Speakers will cover cancer therapy in the context of existing autoimmunity and the triggering of autoimmunity as a result of the cancer therapy.Air date: 4/15/2019 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - December 19, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Eminent Lecture: The Multifaceted Function of the PD-1 Pathway
NCI Center for Cancer Research Eminent Lecture
Arlene Sharpe is the George Fabyan Professor of Comparative Pathology, Head of the Division of Immunology and Interim Co-Chair of the Department of Microbiology and Immunobiology at Harvard Medical School. She is a member of the Department of Pathology at Brigham and Women ’ s Hospital, an Associate Member at the Broad Institute of MIT and Harvard, Leader of the Cancer Immunology Program at the Dana-Farber/Harvard Cancer Center and Co-Director of the Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women ’ s Hospital.
Dr. Sharpe earned h...
Source: Videocast - All Events - September 18, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
National Clinical Care Commission Advisory Committee Meeting - October 2018
The 2018 National Clinical Care commission Advisory Committee evaluates and provides recommendations on the coordination and leveraging of federal programs related to complex metabolic or autoimmune diseases that result from insulin-related issues and represent a significant disease burden in the United States, including complications due to such diseases.Air date: 10/31/2018 8:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - August 16, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Regulating Autoimmunity and Autoinflammation: Cytokine blockade and beyond
Immunonology IG Seminar
Richard Siegel's interest in immunology and apoptosis began in the late 1980's at the University of Pennsylvania School of Medicine where he was an M.D., Ph.D. student. Working with Mark Greene and John Reed, he studied the influence of bcl-2 on T cell apoptosis and repertoire selection. He trained in Internal Medicine and Rheumatology at Hospital of the University of Pennsylvania, and moved to the NIH in 1996 to do postdoctoral training with Michael Lenardo in the Laboratory of Immunology in the National Institute of Allergy and Infectious Disease. There he studied apoptosis signaling and the molec...
Source: Videocast - All Events - May 29, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Sounding the Alarm and Putting Out the Fire: New Mechanistic Insights into Inflammation Triggered by Invasive Infection
NIH Director ’ s Wednesday Afternoon Lecture Series
The Lieberman laboratory studies cytotoxic T lymphocytes and their role in infection and tumor immunity. They study the molecular pathways used by killer lymphocytes and their cytotoxic granule proteases, called granzymes, and pore-forming proteins, perforin and granulysin, to induce programmed cell death. They have defined a caspase-independent programmed cell death pathway activated by granzyme A. Recent work has identified an unexpected role for granzymes and granulysin in protection against bacteria and parasites. They recently uncovered the molecular basis for infl...
Source: Videocast - All Events - May 23, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
B cells in Autoimmune diseases: Focus on Sj ö gren's Syndrome
NIDCR Clinical Research Fellowship Grand Rounds
B cells play a complex role in the development of systemic autoimmune diseases, especially in primary Sj ö gren's syndrome, a progressive condition that damages saliva and tear glands and leads to dry mouth, dry eyes, and other symptoms. Dr. Jacques-Olivier Pers will outline growing evidence that regulatory B lymphocytes (Breg) may blunt the pathogenesis of systemic autoimmune disease, and thus may be potential targets for treatment. Studies of distinct B cell subsets that play differing roles in autoimmune diseases are providing new insights into Breg development and immune...
Source: Videocast - All Events - April 11, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Autoimmunity, Cancer and Immunology (Day 2)
This meeting will focus on 2 issues and will include speakers from the NIH intramural and extramural communities:
Understanding the biology of immune-related adverse events which have occurred in cancer patients being treated with immunotherapies and how that might inform the study of autoimmune disease.
Defining the potential for the study of autoimmune disease to lead to greater understanding of the treatment and management of immune-related adverse events during and following cancer therapies.For more information go tohttps://ncifrederick.cancer.gov/events/CicAutoimmune2018/default.aspAir date: 3/23/2018 8:00:00 AM ...
Source: Videocast - All Events - March 19, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Autoimmunity, Cancer and Immunology (Day 1)
This meeting will focus on 2 issues and will include speakers from the NIH intramural and extramural communities:
Understanding the biology of immune-related adverse events which have occurred in cancer patients being treated with immunotherapies and how that might inform the study of autoimmune disease.
Defining the potential for the study of autoimmune disease to lead to greater understanding of the treatment and management of immune-related adverse events during and following cancer therapies.For more information go tohttps://ncifrederick.cancer.gov/events/CicAutoimmune2018/default.aspAir date: 3/22/2018 8:00:00 AM ...
Source: Videocast - All Events - March 19, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Autotherapies: Enhancing Our Innate Healing Capacity
Autotherapies are treatments based on the body ’ s natural ability to heal and protect itself. For example, immunotherapy harnesses the body ’ s immune cells to fight cancer and is now in clinical use. In the dental, oral, and craniofacial region, autotherapies could be used to selectively signal the body to repair and regenerate tissue, trigger immune responses, and restore a natural microbial balance. These strategies might also help to heal damaged or diseased tissues in other parts of the body, prevent or treat infections, fight cancer, treat autoimmune conditions, and enhance overall health.
Advancing the developm...
Source: Videocast - All Events - December 18, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
A Bacterial Cause of Rheumatoid Arthritis
NIDCR Clinical Research Fellowship Grand Rounds
Understanding the mechanisms which initiate immune responses to autoantigens is of high priority. Significant data implicates mucosal surfaces, specifically the periodontium, the gut, and the lungs, as sites of disease initiation in rheumatoid arthritis (RA), an autoimmune disease characterized by autoantibodies to citrullinated proteins. In recent studies, we identified Aggregatibacter actinomycetemcomitans (Aa), a pathogen associated with chronic and aggressive periodontitis, as a candidate bacterial trigger of autoimmunity in RA. Aa secretes a toxin, leukotoxin A (LtxA), w...
Source: Videocast - All Events - November 8, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
The two faces of the IL-15- Janus Kinase-Stat system: implications for the immunotherapy of autoimmune diseases and cancer
NIH Director's Wednesday Afternoon Lecture Series
Dr. Walmann will present the annual William Paul lecture. Dr. Waldmann defined the IL-2 receptor alpha and beta subunits using the daclizumab antibody he discovered, an antibody that is approved by the FDA. He co-discovered IL-15 and performed the first in-human clinical trial with this agent in patients with malignancy. Furthermore, Waldmann defined molecular abnormalities of the common gamma cytokine, Jak/Stat signaling pathway in HTLV-1 associated adult T-cell lymphoma and translated this discovery with a trial of a Jak inhibitor in patients with this disorder.For more i...
Source: Videocast - All Events - October 26, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Control of Skin Immunity by Non-Immune Cells
Immunonology IG Seminar
The skin is a barrier organ that is a frequent site of entry for numerous pathogens. The skin is able to resist infection through a variety of mechanisms including innate and adaptive immune responses. Resident memory T cells (TRM) are a recently appreciated subset of memory T cells that reside in the skin and are required for optimal protection against previously encountered pathogens. These cells also participate in a number of cutaneous autoimmune diseases including vitiligo, psoriasis and alopecia areata. The skin also contains several populations innate immune cells that provide pathogen protec...
Source: Videocast - All Events - October 3, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Law of STAT fives, root orchestrators of lymphocyte homeostasis and function
Immunology Interest Group Seminar Series
The transcription factor STAT5 is fundamental to the mammalian immune system. Operating downstream of cytokines and growth factors, it impacts all aspects of lymphocyte biology, from general cellular processes like proliferation and apoptosis, to specialized immunological programs like effector and regulatory T cell differentiation. Genetic studies in humans underscore its widespread influence as mutations of STAT5 or upstream activators manifest varied Alejandro Villarino, NIAMS, NIHimmunological phenotypes including immunodeficiency, autoimmunity and hematological malignancies. Mo...
Source: Videocast - All Events - June 20, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
NETting the web in systemic autoimmunity
Immunology Interest Group Seminar Series
Mariana Kaplan, M.D. is Senior Investigator and Chief of the Systemic Autoimmunity Branch at NIAMS/NIH. Prior to her appointment, she was Professor of Medicine in the Division of Rheumatology at the University of Michigan. Dr. Kaplan obtained her medical degree at the National Autonomous University of Mexico and did her Internal Medicine Residency at the National Institute of Medical Sciences and Nutrition in Mexico City. Dr. Kaplan did her Rheumatology Fellowship and postdoctoral training at the University of Michigan, where she was a member of the faculty for 15 years, and an acti...
Source: Videocast - All Events - June 19, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Genetics and immunology of alopecia areata
NIH Director ’ s Wednesday Afternoon Lecture Series
For the past 20 years, Dr. Christiano's research has focused on understanding the molecular processes that lead to inherited skin and hair disorders in humans. Her research career began with the discovery of genetic mutations associated with epidermolysis bullosa, a skin disease that causes severe blistering. Dr. Christiano's recent work has focused on the investigation of the underlying genetic causes of and identification of potential therapies for alopecia areata, an autoimmune form of hair loss.For more information go tohttps://oir.nih.gov/walsAir date: 3/1/2017 3...
Source: Videocast - All Events - February 27, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
