Neonatal mortality and morbidity in Down syndrome in the time of prenatal aneuploidy testing: a retrospective cohort study
Conclusions: Although uptake of prenatal aneuploidy screening increased, neonatal mortality and morbidity in DS appears to be stable. An increased incidence of PPHN was found.What is Known:• The total uptake of prenatal aneuploidy screening for Down syndrome is increasing worldwide.• As a result of increasing prenatal diagnosis of Down syndrome and subsequent termination of pregnancy, the livebirth prevalence of Down syndrome is decreasing.What is New:• Although uptake of prenatal aneuploidy screening increased, neonatal mortality and morbidity in Down syndrome appears to be stable.• An increased incidence of per...
Source: European Journal of Pediatrics - November 9, 2022 Category: Pediatrics Source Type: research

Impact of reintervention during stage 1 palliation hospitalization: a national, multicenter study
CONCLUSIONS: Unplanned reintervention during hospitalization following S1P palliation occurred in 25% of participants in a large, registry based national cohort. Participants who underwent reintervention were more likely to remain inpatient and less likely to survive to S2P. Reintervention was associated with a multitude of postoperative complications that impact survival and long-term outcome.PMID:36306859 | DOI:10.1016/j.athoracsur.2022.10.014 (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 28, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Stephanie S Handler Titus Chan Nancy S Ghanayem Nancy Rudd Gail Wright Alexis Visotcky Rodney Sparapani Michael E Mitchell George M Hoffman Michele A Frommelt Source Type: research

Impact of reintervention during stage 1 palliation hospitalization: a national, multicenter study
CONCLUSIONS: Unplanned reintervention during hospitalization following S1P palliation occurred in 25% of participants in a large, registry based national cohort. Participants who underwent reintervention were more likely to remain inpatient and less likely to survive to S2P. Reintervention was associated with a multitude of postoperative complications that impact survival and long-term outcome.PMID:36306859 | DOI:10.1016/j.athoracsur.2022.10.014 (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 28, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Stephanie S Handler Titus Chan Nancy S Ghanayem Nancy Rudd Gail Wright Alexis Visotcky Rodney Sparapani Michael E Mitchell George M Hoffman Michele A Frommelt Source Type: research

Impact of reintervention during stage 1 palliation hospitalization: a national, multicenter study
CONCLUSIONS: Unplanned reintervention during hospitalization following S1P palliation occurred in 25% of participants in a large, registry based national cohort. Participants who underwent reintervention were more likely to remain inpatient and less likely to survive to S2P. Reintervention was associated with a multitude of postoperative complications that impact survival and long-term outcome.PMID:36306859 | DOI:10.1016/j.athoracsur.2022.10.014 (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 28, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Stephanie S Handler Titus Chan Nancy S Ghanayem Nancy Rudd Gail Wright Alexis Visotcky Rodney Sparapani Michael E Mitchell George M Hoffman Michele A Frommelt Source Type: research

Impact of reintervention during stage 1 palliation hospitalization: a national, multicenter study
CONCLUSIONS: Unplanned reintervention during hospitalization following S1P palliation occurred in 25% of participants in a large, registry based national cohort. Participants who underwent reintervention were more likely to remain inpatient and less likely to survive to S2P. Reintervention was associated with a multitude of postoperative complications that impact survival and long-term outcome.PMID:36306859 | DOI:10.1016/j.athoracsur.2022.10.014 (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 28, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Stephanie S Handler Titus Chan Nancy S Ghanayem Nancy Rudd Gail Wright Alexis Visotcky Rodney Sparapani Michael E Mitchell George M Hoffman Michele A Frommelt Source Type: research

Impact of reintervention during stage 1 palliation hospitalization: a national, multicenter study
CONCLUSIONS: Unplanned reintervention during hospitalization following S1P palliation occurred in 25% of participants in a large, registry based national cohort. Participants who underwent reintervention were more likely to remain inpatient and less likely to survive to S2P. Reintervention was associated with a multitude of postoperative complications that impact survival and long-term outcome.PMID:36306859 | DOI:10.1016/j.athoracsur.2022.10.014 (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 28, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Stephanie S Handler Titus Chan Nancy S Ghanayem Nancy Rudd Gail Wright Alexis Visotcky Rodney Sparapani Michael E Mitchell George M Hoffman Michele A Frommelt Source Type: research

Surgical Outcomes of Congenital Heart Disease in Down Syndrome: Tertiary Center  Experience—Focus on the Electrical Conduction System
AbstractTo document outcomes of cardiac surgical repair in Down syndrome (DS) patients with specific focus on the associated electrical conduction morbidities, ultimately leading to a higher incidence of pacemaker implantation (PMI). A retrospective study conducted between 2011 and 2020. A total of 167 DS patients undergoing 204 surgeries were included. The mean gestational age (GA) and mean weight were 37.3  weeks and 5.5 kg, respectively. Complete atrioventricular septal defect (AVSD) was the most common diagnosis. Pre-operative ECG revealed superior axis deviation (SAD) in 92 and 32% of patients with AVSD and isolated...
Source: Pediatric Cardiology - October 19, 2022 Category: Cardiology Source Type: research

Surgical Outcomes of Congenital Heart Disease in Down Syndrome: Tertiary Center  Experience—Focus on the Electrical Conduction System
AbstractTo document outcomes of cardiac surgical repair in Down syndrome (DS) patients with specific focus on the associated electrical conduction morbidities, ultimately leading to a higher incidence of pacemaker implantation (PMI). A retrospective study conducted between 2011 and 2020. A total of 167 DS patients undergoing 204 surgeries were included. The mean gestational age (GA) and mean weight were 37.3  weeks and 5.5 kg, respectively. Complete atrioventricular septal defect (AVSD) was the most common diagnosis. Pre-operative ECG revealed superior axis deviation (SAD) in 92 and 32% of patients with AVSD and isolated...
Source: Mammalian Genome - October 19, 2022 Category: Genetics & Stem Cells Source Type: research

Single-Stage Surgical Management of Atrioventricular Septal Defects with Coarctation of the Aorta
AbstractSurgical options for coarctation of aorta (CoA) with atrioventricular septal defect (AVSD) include single-stage repair vs. staged approach with neonatal CoA repair and delayed AVSD repair. The durability of left atrioventricular valve (LAVV) function after neonatal repair is questioned, and the optimal approach remains controversial. Eighteen CoA-AVSD patients who underwent single-stage repair 2005 –2015 by a single surgeon were retrospectively analyzed. Fifteen patients had complete and three had partial AVSD. Birth weight was 3.19 kg (2.17–4.08). Age at surgery was 16 days (6–127). One- and ten-year survi...
Source: Mammalian Genome - September 21, 2022 Category: Genetics & Stem Cells Source Type: research

Single-Stage Surgical Management of Atrioventricular Septal Defects with Coarctation of the Aorta
AbstractSurgical options for coarctation of aorta (CoA) with atrioventricular septal defect (AVSD) include single-stage repair vs. staged approach with neonatal CoA repair and delayed AVSD repair. The durability of left atrioventricular valve (LAVV) function after neonatal repair is questioned, and the optimal approach remains controversial. Eighteen CoA-AVSD patients who underwent single-stage repair 2005 –2015 by a single surgeon were retrospectively analyzed. Fifteen patients had complete and three had partial AVSD. Birth weight was 3.19 kg (2.17–4.08). Age at surgery was 16 days (6–127). One- and ten-year survi...
Source: Pediatric Cardiology - September 21, 2022 Category: Cardiology Source Type: research

Atrioventricular septal defect with an absent or tiny ostium primum defect: a case series of three surgical cases
AbstractAlthough atrioventricular septal defects are categorized according to the anatomical atrioventricular orifice, the location of the intracardiac shunt in atrioventricular septal defects is important from a surgical perspective. Herein, we report three cases of atrioventricular septal defects with a small or no ostium primum defect. Case 1 (3-month-old girl) was diagnosed preoperatively with a ventricular septal defect, secundum atrial septal defect, and mitral valve cleft. After the operation, the diagnosis was corrected to an atrioventricular septal defect and was repaired completely. Case 2 (9-year-old girl) under...
Source: Indian Journal of Thoracic and Cardiovascular Surgery - September 13, 2022 Category: Cardiovascular & Thoracic Surgery Source Type: research

Detection rates of a national fetal anomaly screening programme: a national cohort study
CONCLUSIONS: The performance of the FA scan is above the expectations set in 2010 for most conditions. For the remaining conditions, the majority of fetuses and babies are detected prior to the FA scan.PMID:36054171 | DOI:10.1111/1471-0528.17287 (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - September 2, 2022 Category: OBGYN Authors: Nicholas Aldridge Pranav Pandya Judith Rankin Nicola Miller Jennifer Broughan Nadia Permalloo Annette McHugh Sarah Stevens Source Type: research