Gene mutation defines brain tumors that benefit from aggressive surgery
A new study has found that malignant astrocytoma patients whose tumors carry a specific genetic mutation benefit greatly from surgical removal of the largest possible amount of tumor. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 3, 2014 Category: Science Source Type: news
Gene mutation defines brain tumors that benefit from aggressive surgery
(Massachusetts General Hospital) A new study has found that malignant astrocytoma patients whose tumors carry a specific genetic mutation benefit greatly from surgical removal of the largest possible amount of tumor. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 3, 2014 Category: Cancer & Oncology Source Type: news
VRK2 Identifies Primary Astrocytomas With a Better PrognosisVRK2 Identifies Primary Astrocytomas With a Better Prognosis
This study explores the potential value of VRK2 protein expression as a prognostic marker in high-grade astrocytomas. BMC Clinical Pathology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 6, 2013 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news
What Neoplasms are Patients with Neurofibromatosis At Risk For?
Discussion
Neurofibromatosis Type 1 (NF1) is one of many neurocutaneous diseases with a probable underestimated incidence of 1:3000. Also called phacomatoses, a review can be found at: What is the Epidemiology and Genetics of the Major Phacomatoses?
The key elements of NF1 are:
Neurofibromatosis Type 1
Epidemiology: 1:2500-3000 – most common phacomatosis
Genetics: autosomal dominant with variable penetrance, associated with chromosome 17
Neurological: various central nervous system tumors especially neurofibromas (often benign but may act malignant because of location or size, tumors may also degenerate into a ma...
Source: PediatricEducation.org - September 23, 2013 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
What Neoplasms are Patients with Neurofibromatosis At Risk For?
Discussion
Neurofibromatosis Type 1 (NF1) is one of many neurocutaneous diseases with a probable underestimated incidence of 1:3000. Also called phacomatoses, a review can be found at: What is the Epidemiology and Genetics of the Major Phacomatoses?
The key elements of NF1 are:
Neurofibromatosis Type 1
Epidemiology: 1:2500-3000 – most common phacomatosis
Genetics: autosomal dominant with variable penetrance, associated with chromosome 17
Neurological: various central nervous system tumors especially neurofibromas (often benign but may act malignant because of location or size, tumors may also degenerate into a ma...
Source: PediatricEducation.org - September 23, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news
Diagnostic Role and Relevance of BRAF Status in Brain TumorsDiagnostic Role and Relevance of BRAF Status in Brain Tumors
Targeted therapies have potential for treating gliomas and astrocytomas. Personalized Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 24, 2013 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
Suspicions confirmed: Brain tumors in children have a common cause
(Helmholtz Association of German Research Centres) An overactive signaling pathway is a common cause in cases of pilocytic astrocytoma, the most frequent type of brain cancer in children. This was discovered by a network of scientists coordinated by the German Cancer Research Center (as part of the International Cancer Genome Consortium, ICGC). In all 96 cases studied, the researchers found defects in genes involved in a particular pathway. Hence, drugs can be used to help affected children by blocking components of the signaling cascade. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 9, 2013 Category: Global & Universal Source Type: news
Tumors of the Central Nervous System, Volume 9
Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomasseries:Tumors of the Central Nervous SystemThe ninth volume in this essential series discusses key advances in our understanding of neoplasms in the human central nervous system. This publication deals with various aspects of nine separate types of brain tumors. With 70 contributors from 17 nations, this edition offers an unrivalled thoroughness and breadth of coverage that includes the very latest research results on the following ... (Source: Springer Biomedical Sciences titles)
Source: Springer Biomedical Sciences titles - February 12, 2013 Category: Biomedical Science Tags: Biomedicine (general) Source Type: news
Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): RCT
Source: Lancet
Area: News
Tuberous sclerosis is a rare debilitating disease affecting one in 5800 livebirths and fewer than one million people worldwide. It is associated with multiple lesions including renal angiomyolipoma, brain subependymal giant-cell astrocytomas, and pulmonary lymphangioleiomyomatosis. Angiomyolipomas are slow-growing tumours, which predispose patients to serious complications including retroperitoneal haemorrhage and impaired renal function. The condition is caused by mutations in either TSC1 or TSC2 suppressor genes, resulting in increased mTOR activity. Hence, mTOR inhibitors have a rationale for ...
Source: NeLM - News - January 11, 2013 Category: Drugs & Pharmacology Source Type: news
Brain Tumor: Glioblastoma
Glioblastoma is a type of primary malignant brain tumor. Glioblastoma is also known as grade 4 (IV) astrocytoma, Glioblastoma multiforme and GBM. (Source: MyBiopsy.org)
Source: MyBiopsy.org - October 7, 2009 Category: Cancer & Oncology Source Type: news
Brain Tumor: Anaplastic Astrocytoma
Anaplastic Astrocytoma is a primary grade III (malignant) brain tumor. Anaplastic Astrocytoma comprises about 4 percent of all primary brain tumors diagnosed in the United States. (Source: MyBiopsy.org)
Source: MyBiopsy.org - October 7, 2009 Category: Cancer & Oncology Source Type: news
Brain Tumor: Pilocytic Astrocytoma
Pilocytic Astrocytoma is a type of benign brain tumor that rarely spreads into surrounding tissues. Starting in brain cells called astrocytes, this type of tumor is slow-growing tumor but can become very large. (Source: MyBiopsy.org)
Source: MyBiopsy.org - October 7, 2009 Category: Cancer & Oncology Source Type: news
