COVID-19 vaccines: Safety, side effects –– and coincidence
As the pandemic rages on, it’s increasingly clear that widespread vaccination is essential to help contain it. Physical distancing, universal face coverings, and frequent handwashing are effective, but not foolproof. And of course, these measures don’t work if they are not followed. So, the rapid development of mRNA vaccines and other vaccines to prevent COVID-19 is welcome — some say miraculous — news. But while many people are scrambling to get a vaccine, others are hesitating. Start here: Are these vaccines safe and effective? It’s natural to wonder if brand new vaccines against a novel coronavirus, developed ...
Source: Harvard Health Blog - February 8, 2021 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Vaccines Source Type: blogs

COVID-19 vaccines: Safety, side effects — and coincidence
As the pandemic rages on, it’s increasingly clear that widespread vaccination is essential to help contain it. Physical distancing, universal face coverings, and frequent handwashing are effective, but not foolproof. And of course, these measures don’t work if they are not followed. So, the rapid development of mRNA vaccines and other vaccines to prevent COVID-19 is welcome — some say miraculous — news. But while many people are scrambling to get a vaccine, others are hesitating. Start here: Are these vaccines safe and effective? It’s natural to wonder if brand new vaccines against a novel coronavirus, developed ...
Source: Harvard Health Blog - February 8, 2021 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Vaccines Source Type: blogs

Cross Post: Not Recommending AstraZeneca Vaccine For The Elderly Risks The Lives Of The Most Vulnerable
Jonathan Pugh, University of Oxford and Julian Savulescu, University of Oxford Regulators in Europe are at odds over whether the Oxford/AstraZeneca vaccine should be given to the elderly. In the UK, the vaccine has been approved for use in adults aged 18 and up, but France, Germany, Sweden and Austria say the vaccine should be […] (Source: blog.bioethics.net)
Source: blog.bioethics.net - February 8, 2021 Category: Medical Ethics Authors: Practical Ethics Tags: Health Care Coronavirus; Pandemic; Ethics; Public Health COVID-19 Cross Post Jonny Pugh's Posts Julian Savulescu's Posts syndicated The Conversation the elderly and vulnerable vaccinations Source Type: blogs

#ThisIsOurShot to end the pandemic
If 2020 was the year of the coronavirus pandemic, 2021 has got to be the year of vaccinations. The miracle of modern science, generous funding, and expedited research have led to us having at least three available vaccines to fight against the COVID-19 pandemic. Pfizer/ BioNtech, Moderna, and most recently, AstraZeneca have produced vaccines that […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 2, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/anupama-verma" rel="tag" > Anupama Verma, MD < /a > < /span > Tags: Conditions COVID-19 coronavirus Infectious Disease Source Type: blogs

TWiV 693: Vax to the future
On this episode, FDA EUA for Pfizer mRNA vaccine, efficacy of AstraZeneca ChAdOx1 COVID-19 vaccine, and an orally administered drug that blocks SARS-CoV-2 transmission in ferrets. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Click arrow to playDownload TWiV 693 (69 MB .mp3, 115 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - December 17, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral drug ChAdOx1 coronavirus COVID-19 EIDD-2801 ferret MK-4482 mRNA vaccine nucleoside analog pandemic Pfizer SARS-CoV-2 virus transmission viruses Source Type: blogs

TWiV 685: Pandemicky
The TWiVers analyze efficacy of the AstraZeneca/Oxford adenovirus vectored vaccine, SARS-CoV-2 did not infect miners who became ill 8 years ago after cleaning bat guano from a cave in Yunnan Province, and induction of antigen-specific germinal center responses and production of neutralizing antibody by SARS-CoV-2 mRNA vaccine but not purified protein. Click arrow to playDownload TWiV […] (Source: virology blog)
Source: virology blog - November 27, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology bat guano coronavirus COVID-19 follicular T helper cell germinal center memory B cell mRNA vaccine neutralizing antibody pandemic protein vaccine RaTG13 SARS-CoV-2 spike protein viral viruses Source Type: blogs

Eko Raises $65 Million in Series C Funding to Close the Gap Between Virtual and In-Person Heart and Lung Care
Eko, a cardiopulmonary digital health company, today announced $65 million in Series C funding led by Highland Capital Partners and Questa Capital, with participation from Artis Ventures, DigiTx Partners, NTTVC, 3M Ventures, and other new and existing investors. The new funding will be used to expand in-clinic use of the company’s platform of telehealth and […] (Source: EMR and HIPAA)
Source: EMR and HIPAA - November 11, 2020 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Telemedicine and Remote Monitoring 3M 3M Ventures Artis Ventures AstraZeneca Connor Landgraf Corey Mulloy Digital Stethoscope DigiTx Partners Dr. Ami Bhatt ECG Eko Health IT Funding Highland Ca Source Type: blogs

COVID-19 Vaccines Depend on Globalization (And, Therefore, So Does the Trump Administration)
Scott LincicomeLast week, theWall Street Journalexamined government efforts to secure early access to doses of the most advanced COVID-19 vaccines, and how this access could prove to be a game‐​changer for these economies in 2021. As shown in the following WSJ chart, many governments have contracted with multiple pharmaceutical companies in order to ensure that they have access to at least one vaccine that successfully completes “Phase III” trials, which are now underway for most of the listed drugs. Among these governments is the United States, which has thus far secured vaccine commitments from Oxford/​Ast...
Source: Cato-at-liberty - October 12, 2020 Category: American Health Authors: Scott Lincicome Source Type: blogs

The AstraZeneca/Oxford University Phase 3 COVID-19 Vaccine Trial – Why Was It Paused?
by Helen Stillwell Recently, a Phase 3 trial investigating a COVID-19 vaccine (AZD1222) being developed by AstraZeneca and the University of Oxford was put on hold in the US following a report of an adverse event in a study participant in the U.K. (Feuerstein 2020). One of the predominant vaccine candidates against SARS-CoV-2, AZD1222 is […] (Source: virology blog)
Source: virology blog - September 17, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Helen Stilwell Information AstraZenca ChAdOx1 COVID-19 Oxford University pandemic SARS-CoV-2 transverse myelitis vaccine viral virus viruses Source Type: blogs

Everyone should support abortion-free vaccines
by Mark Christopher Navin, PhD; Michael Redinger, MD, MA Some leading COVID-19 vaccine candidates—including those being developed by Oxford University/AstraZeneca and Moderna—use fetal cell lines derived from abortions. Other candidate COVID-19 vaccines do not, for example those being developed by Sanofi Pasteur and GlaxoSmithKline. We do not know which, if any, of the candidate COVID-19 vaccines will be successful. Prominent Catholic and pro-life voices in the US and elsewhere have objected to the development of vaccines with materials derived from aborted fetuses, but few people outside of...
Source: blog.bioethics.net - September 15, 2020 Category: Medical Ethics Authors: Blog Editor Tags: Featured Posts Politics Public Health Reproductive Ethics #covid19 #diaryofaplagueyear COVID-19 fetal cells religion vaccines Source Type: blogs

Preliminary phase I/II results of ChAdOx1 SARS-CoV-2 vaccine
by Gertrud U. Rey On July 20, 2020, Oxford University’s Jenner Institute and the pharmaceutical company AstraZeneca reported preliminary results from phase I/II clinical trials assessing the safety and efficacy of a vaccine candidate against SARS-CoV-2.  The vaccine candidate, named AZD1222 (referred to in the publication as ChAdOx1 nCoV-19), consists of an adenovirus vector with an […] (Source: virology blog)
Source: virology blog - July 23, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information adenovirus AstraZeneca ChAdOx1 COVID-19 Oxford University pandemic SARS-CoV-2 vaccine viral viruses Source Type: blogs

Vaccines for COVID-19 moving closer
As the world reels from illnesses and deaths due to COVID-19, the race is on for a safe, effective, long-lasting vaccine to help the body block the novel coronavirus SARS-CoV-2. The three vaccine approaches discussed here are among the first to be tested clinically in the United States. How vaccines induce immunity: The starting line In 1796, in a pastoral corner of England, and during a far more feudal and ethically less enlightened time, Edward Jenner, an English country surgeon, inoculated James Phipps, his gardener’s eight-year-old son, with cowpox pustules obtained from the arm of a milkmaid. It was widely believed ...
Source: Harvard Health Blog - July 21, 2020 Category: Consumer Health News Authors: Shiv Pillai, PhD, MBBS Tags: Coronavirus and COVID-19 Health Infectious diseases Vaccines Source Type: blogs

You think insurance is confusing? Try being a patient.
My husband is a type 2 diabetic with mild chronic kidney disease, which has been well controlled on 500 mg metformin BID plus saxagliptin (AstraZeneca’s Onglyza). At the end of last year, he got a letter from his Medicare Advantage PPO, UnitedHealthcare (UHC), advising him that the Onglyza (UHC only uses brand names) would no […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 4, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/lynne-peterson" rel="tag" > Lynne Peterson < /a > < /span > Tags: Patient Diabetes Medications Source Type: blogs

Liver Chip Avoids Animal Testing, Makes Drug Research Easier, Faster
Low liver toxicity is a major hurdle that drug candidates have to demonstrate before they are used as therapeutic medications. This testing is usually performed using animals, including rodents and dogs, with livers that aren’t quite like ours. Animal studies are useful, but they often result in misleading information, which may not be realized until long into the drug development process. Sometimes, patients are injured by such drug candidates when liver toxicity isn’t properly assessed ahead of time. Now, a research collaboration involving scientists from Emulate, a Boston-based firm, AstraZeneca, Janssen ...
Source: Medgadget - December 5, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Materials Medicine Source Type: blogs