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Global Production of Active Pharmaceutical Ingredients for US Generic Drugs Experiencing Shortages
This study evaluates the characteristics of generic active pharmaceutical ingredients (APIs) used to manufacture drugs with shortages in the US and facilities producing APIs worldwide. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 29, 2024 Category: General Medicine Source Type: research

Outcomes Following Localized Prostate Cancer Treatment
To the Editor A recent study reported approximately 10-year follow-up data on functional outcomes of patients after treatment for localized prostate cancer, providing essential evidence-based medical evidence for clinical decision-making. We have 2 concerns regarding the data analyses on sexual function after radical prostatectomy. First, apart from androgen deprivation therapy, the potential influence of salvage radiotherapy on sexual function also needs to be considered because this therapy is frequently used after radical prostatectomy in clinical settings, especially among patients with unfavorable-prognosis prostate c...
Source: JAMA - Journal of the American Medical Association - April 29, 2024 Category: General Medicine Source Type: research

Outcomes Following Localized Prostate Cancer Treatment
To the Editor In a recent article that compared adverse outcomes of localized prostate cancer treatment modalities, persistent urinary incontinence after radical prostatectomy was highlighted as a significant difference compared with other therapeutic options. However, the authors overlooked the existence of safe and effective curative options for postprostatectomy incontinence management. When pelvic floor muscle training after prostatic surgery is ineffective for postprostatectomy incontinence, various surgical options such as the artificial urinary sphincter or minimally invasive alternatives such as periurethral balloo...
Source: JAMA - Journal of the American Medical Association - April 29, 2024 Category: General Medicine Source Type: research

Outcomes Following Localized Prostate Cancer Treatment —Reply
In Reply In response to our recent article, Drs Huang and Ding question the validity of using questionnaires to assess sexual function. While a patient ’s responses are subjective (ie, indicating how their function seems to them rather than it being measured more objectively), the use of standardized, validated instruments for patient-reported outcomes remains the standard for both clinical and research purposes. Furthermore, any subjectivity-bas ed misclassification would be expected to be nondifferential and, therefore, should not affect our comparative results. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 29, 2024 Category: General Medicine Source Type: research

Aspirin vs Placebo as Adjuvant Therapy for Breast Cancer
This study examines the potential benefits of aspirin as adjuvant therapy for survivors of early breast cancer. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 29, 2024 Category: General Medicine Source Type: research

At-Home Diagnostics Solutions for Chlamydia and Gonorrhea
This Viewpoint discusses the US Food and Drug Administration ’s authorization of marketing an at-home testing system for chlamydia and gonorrhea as a good first step in boosting access to screening and treatment and in reducing infection rates. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 29, 2024 Category: General Medicine Source Type: research

Poll: Patients Still Trust Their Physicians the Most
This Medical News article discusses a KFF poll about the public ’s exposure to and beliefs about inaccurate health information, as well as media use and trust in sources. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 26, 2024 Category: General Medicine Source Type: research

Introducing JAMA Data Brief
How people consume information is evolving. So is JAMA Medical News. This issue debuts JAMA Data Brief, a new department in the journal ’s long-standing Medical News& Perspectives. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 26, 2024 Category: General Medicine Source Type: research

US Updates Race, Ethnicity Categories for First Time Since 1997
People answering survey questions and filling out administrative forms from federal agencies will now answer 1 combined question about race and ethnicity and be able to select more than 1 option that represents their identity, the US Office of Management and Budget (OMB) announced in a recent statement. The OMB also added a new category for race and ethnicity: Middle Eastern or North African. The revisions are the first in almost 2 decades to the way the federal government characterizes race and ethnicity. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 26, 2024 Category: General Medicine Source Type: research

CDC Warns of Surge in Meningococcal Disease in US
As of late March 2024, health officials in the US have recorded 143 cases of meningococcal disease, 101 of them caused by a strain of the bacteria Neisseria meningitidis known as sequence type (ST) 1466. The total number of cases of the disease represents a more than 75% increase over those reported at the same time last year, the US Centers for Disease Control and Prevention (CDC) announced. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 26, 2024 Category: General Medicine Source Type: research

New Rules Require Explicit Consent for Students to Perform Sensitive Exams
Clinicians must now get written consent for medical students to conduct examinations or invasive procedures —such as breast, pelvic, prostate, and rectal checks—on patients for the trainees’ education, the US Department of Health and Human Services announced in a recent letter to teaching hospitals and medical schools. The guidance reinforces what is already standard care at many major institutions and aligns with several states’ current laws, according to the letter. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 26, 2024 Category: General Medicine Source Type: research

Dengue Cases Surge in Latin America and Caribbean
Millions of people in the Americas have been infected with dengue and more than 1000 have died in the first 3 months of 2024, tripling the number of dengue cases that occurred in 2023 during the same period, according to a statement by the Pan American Health Organization (PAHO). Last year, more than 4.5 million cases of the mosquito-borne illness were reported in the region, which itself was a record. Still, the case fatality rate remained low, a trend that Jarbas Barbosa, MD, PhD, MS, the director of PAHO, called “very encouraging.” (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 26, 2024 Category: General Medicine Source Type: research

Abnormal Glucose, Triglycerides Linked to Later Psychiatric Conditions
People with high levels of blood glucose and triglycerides tended to have a greater risk of mental health conditions later than those who had normal levels of both, according to data from more than 211  000 participants in Sweden published in JAMA Network Open. Changes in some biomarkers were evident up to 20 years before participants were diagnosed. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 26, 2024 Category: General Medicine Source Type: research

Limited Pregnancy Weight Gain for People With Obesity Might Be Safe
People with obesity who gained less than the recommended 5 kg to 9 kg of weight during pregnancy did not experience adverse outcomes, and neither did their children, according to data from about 15  800 pregnancies among people with obesity in Sweden. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 26, 2024 Category: General Medicine Source Type: research

Climbers at High Altitudes at Risk of Heart Rhythm Abnormalities
More than one-third of climbers who were exposed to the low-pressure and low-oxygen environment of Mount Everest experienced a cardiac arrhythmia during their climb, a small study found. The data came from 41 healthy men who were, on average, in their mid-30s. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 26, 2024 Category: General Medicine Source Type: research