I Kept Crying
In this narrative medicine essay, a second-year pediatric resident bears the scars from the terror that descended the moment of her son ’s birth at 31 weeks’ gestation, terror relived even after he has come home healthy. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - May 16, 2024 Category: General Medicine Source Type: research

Errors in Results From Erroneous Exclusion of Participants in Analysis
This article was corrected online. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - May 16, 2024 Category: General Medicine Source Type: research

Sex Differences in Primary Care –Based Chronic Kidney Disease Management
This retrospective study uses electronic health record data to investigate the sex differences in guideline-based management outcomes between male and female patients with chronic kidney disease. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - May 16, 2024 Category: General Medicine Source Type: research

Error in the Exclusion of Participants From Analysis in the ACTIV-6 Platform Randomized Clinical Trial
This article reported the findings of the double-blind Accelera ting COVID-19 Therapeutic Interventions and Vaccines 6 (ACTIV-6) platform randomized clinical trial of 1206 US adults with COVID-19 who received a targeted dose of 600 μg/kg of ivermectin or placebo for 6 days during February 2022 to July 2022. The primary outcome was time to sustained recovery, de fined as at least 3 consecutive days without symptoms. As we reported, “the median time to sustained recovery was 11 days in the ivermectin group and 11 days in the placebo group. In this largely vaccinated (84%) population, the posterior probability that ivermec...
Source: JAMA - Journal of the American Medical Association - May 16, 2024 Category: General Medicine Source Type: research

Blood Testing for Phosphatidylethanol
A 36-year-old man with obesity and dyslipidemia presented with elevated liver enzymes following a liver transplant to treat acute-on-chronic liver failure due to alcohol-associated hepatitis. What would you do next? (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - May 15, 2024 Category: General Medicine Source Type: research

Mortality in Patients Hospitalized for COVID-19 vs Influenza in Fall-Winter 2023-2024
This cohort study evaluates the risk of death in patients hospitalized for COVID-19 or seasonal influenza following the emergence of the JN.1 variant in winter 2023. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - May 15, 2024 Category: General Medicine Source Type: research

Even Joy
Since her birth with half a brain The doctors have been kind, So awed by her determination they loan a private Room for the transient child to be and Show the worth of being Even if (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - May 15, 2024 Category: General Medicine Source Type: research

Poetry and the Meaning of Care
Health care is becoming more and more distanced. Clinicians must overcome not just mountains of data, burdensome electronic health records, and ever-increasing numbers of machines that separate us from patients, but more recently also navigate telemedicine and AI-driven chatbots. Physician-writer Dr Abraham Verghese and others have lamented that consequently we rely less on the physical exam and the connection it fosters with patients, as echocardiography and CT scans impersonally scrutinize them instead. So, a poem like “Even Joy” is a welcome corrective, a poignant reminder of the value of simple human touch in medic...
Source: JAMA - Journal of the American Medical Association - May 15, 2024 Category: General Medicine Source Type: research

Fosamax Fractures
This Viewpoint discusses the ongoing lawsuit between plaintiffs who had been affected by atypical femoral fractures while receiving alendronate and the drug manufacturer. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - May 15, 2024 Category: General Medicine Source Type: research

Lifestyle Interventions for Obesity in the Era of GLP-1 Receptor Agonists
A central goal of obesity treatment is sustaining weight loss of at least 5%, with at least 10% weight loss conferring greater cardiometabolic health benefits. As new pharmacological antiobesity therapies emerge, including incretin-based treatments that produce a mean of 15% to 21% weight loss, the utility of lower-intensity, lifestyle-based interventions could be questioned. In this issue of JAMA, Hoddinott et al and Spring et al present results from 2 remotely delivered behavioral weight loss interventions. Hoddinott et al compared 2 weight loss interventions to a wait-list control group in middle-aged men with obesity i...
Source: JAMA - Journal of the American Medical Association - May 14, 2024 Category: General Medicine Source Type: research

An Adaptive Behavioral Intervention for Weight Loss Management
This noninferiority randomized trial compares the effects of a wireless system designed to provide daily feedback on progress in lifestyle change and weight loss vs the same system with additional human coaching on weight change among people with overweight and obesity. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - May 14, 2024 Category: General Medicine Source Type: research

Text Messages With Financial Incentives for Men With Obesity
This randomized clinical trial assesses whether text messaging combined with financial incentives or text messages alone could help men with obesity lose weight at 12 months. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - May 14, 2024 Category: General Medicine Source Type: research

Can Cardiovascular Risk Assessment Be Improved in the 21st Century?
Cardiovascular risk assessment has become an essential part of preventive strategies designed to target risk factor interventions and has contributed to dramatic reductions in cardiovascular disease mortality during the past 60 years in the US and other countries. Beginning in the 1960s, investigators from the Framingham Heart study identified key physiological, behavioral, and biochemical risk factors for atherosclerotic cardiovascular disease and were the first to develop multivariable risk equations using major risk factors to predict first-time fatal and nonfatal myocardial infarction and later atherosclerotic cardiova...
Source: JAMA - Journal of the American Medical Association - May 13, 2024 Category: General Medicine Source Type: research

Apixaban to Prevent Recurrence After Cryptogenic Stroke
To the Editor A recent clinical trial demonstrated that apixaban did not significantly reduce recurrent stroke risk compared with aspirin in patients with cryptogenic stroke and evidence of atrial cardiopathy without atrial fibrillation. However, we had some concerns about this study. First, it is likely that a substantial number of patients with patent foramen ovale (PFO) were enrolled in this study, but no data about them were presented. Both in vivo and in vitro studies have shown that left atrial function is impaired in patients who have a PFO and large right-to-left shunt, resembling the atrial cardiomyopathy observed...
Source: JAMA - Journal of the American Medical Association - May 13, 2024 Category: General Medicine Source Type: research

Apixaban to Prevent Recurrence After Cryptogenic Stroke
To the Editor We have several concerns about the recent trial that examined apixaban for prevention of recurrence after cryptogenic stroke in patients with atrial cardiopathy. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - May 13, 2024 Category: General Medicine Source Type: research