The Promise of a Longer Lifetime
Modern hygiene has been described as the reaction against the old fatalistic creed that deaths inevitably occur at a constant rate. The study of vital statistics shows that there is no “iron law of mortality.” According to a report prepared for the National Conservation Commission fifteen years ago, statistics for India showed that the average duration of life there was less than twenty-five years. In Sweden it was over fifty years; in Massachusetts, forty-five years. The leng th of life is increasing wherever sanitary science and preventive medicine are applied. In India it is stationary. In Europe it doubled in three...
Source: JAMA - Journal of the American Medical Association - April 18, 2024 Category: General Medicine Source Type: research

Estrogen-Only Hormone Therapy and Dementia
To the Editor A recent study reported an increased dementia risk in women using estrogen-only menopausal hormone therapy, which mirrors findings of an earlier study by these authors that demonstrated an increased dementia risk associated with combined menopausal hormone therapy. These studies have many similar limitations, including confounding by indication, multiple sources of bias, and failure to adjust for factors known to influence dementia risk. In a similar study that adjusted for multiple confounding factors, estrogen-only hormone therapy was associated with a 1.1% decrease in dementia risk per year when used for m...
Source: JAMA - Journal of the American Medical Association - April 18, 2024 Category: General Medicine Source Type: research

Estrogen-Only Hormone Therapy and Dementia
This article has several limitations that should be considered when interpreting the study ’s findings. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 18, 2024 Category: General Medicine Source Type: research

Estrogen-Only Hormone Therapy and Dementia —Reply
In Reply The Letters about our study suggest that the observed positive association between estrogen-only hormone therapy and dementia could have been influenced by (1) potential confounding by indication of hysterectomy-induced early menopause among estrogen-only hormone therapy users or (2) potential late estrogen-only hormone therapy initiation distant from menopause, previously linked to increased risk of dementia. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 18, 2024 Category: General Medicine Source Type: research

Patient Information: Hepatitis D Infection
This JAMA Patient Page describes hepatitis D infection and its risk factors, outcomes of acute and chronic infection, diagnosis, treatment, and prevention. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 18, 2024 Category: General Medicine Source Type: research

“The Patient”
When a resident announced that “the patient has no chance of surviving,” a medical student, in this narrative medicine essay, has pondered for years how her mother could have been so reduced and advocates using patients’ names when summarizing their conditions. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 18, 2024 Category: General Medicine Source Type: research

A Patient with Diabetes Mellitus and Acute Rhinosinusitis
A 41-year-old with type 1 diabetes had generalized weakness, muffled voice, and slurred speech. Neck computed tomography showed soft-tissue gas in the nasopharynx and prevertebral fascia; examination of sinus mucosal samples identified numerous broad, nonseptate right-angled hyphae and fruiting bodies. What is the diagnosis and what would you do next? (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 17, 2024 Category: General Medicine Source Type: research

Main Residency Match for Applicants With Disability
This cohort study assesses match rates of US applicants with and without disability into specialty residence programs. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 17, 2024 Category: General Medicine Source Type: research

Tirzepatide for Maintenance of Weight Reduction in Adults with Obesity
To the Editor As reported by Dr Aronne and colleagues, tirzepatide demonstrates therapeutic benefits in weight loss; adults with obesity completing the 36-week lead-in period of the trial experienced a mean weight reduction of 20.9%. From randomization at week 36, those who switched to receiving placebo had a 14% weight regain, while those continuing tirzepatide achieved an additional 5.5% weight reduction during the 52-week double-blind period. However, we have several concerns. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 17, 2024 Category: General Medicine Source Type: research

Tirzepatide for Maintenance of Weight Reduction in Adults with Obesity —Reply
In Reply The authors raise 5 issues related to our trial of tirzepatide. First, the glucagon-like peptide-1 (GLP-1) receptor agonist class has been available for the treatment of type 2 diabetes since 2005 and for the treatment of obesity since 2014, and has been the subject of increasing worldwide use. Although nausea, diarrhea, constipation, and vomiting are the most common adverse effects of this class of medication, appropriate clinical treatment of patients can reduce these common adverse effects and increase tolerability. Such treatment includes slow titration or downtitration of the medication or symptomatic managem...
Source: JAMA - Journal of the American Medical Association - April 17, 2024 Category: General Medicine Source Type: research

Open MRI
I keep my mother ’s dentures warm; they fog the plastic case on my lap. Lips pursed, arms raised above her head, she lies on a table about to slide through the doughnut of an apparatus that looks like a spaceship. I hear David Bowie’s voice: This is Ground Control to Major Tom as the contraption begins its magne tic music— an opus of hammers, a staccato hum. What a brave astronaut my mother is, fitted into a coil helmet, going in alone. She waves off my hand to hold, refuses earbuds the technician offers. I’d give anything if we were anywhere else. Strange, the way I now drift above her, the technician and the mach...
Source: JAMA - Journal of the American Medical Association - April 17, 2024 Category: General Medicine Source Type: research

Understatement in Poetry (Quieter Than an MRI)
Understatement, or “showing without telling,” makes writing in prose and especially in poetry pleasing to read. Medical training, in contrast, is rife with exhaustive explanation. “Open MRI” demonstrates the effect of understatement. The poem brims with implied yet revealing comparisons: the massive, coldly im personal MRI scanner that swallows the speaker’s mother and the small, oddly intimate denture case kept warm in the hands of the daughter; the eerily soothing, mentally replayed Bowie song lyrics vs the overtly loud magnetic clanging of the machine; the precise processing of details of the mother’ s inter...
Source: JAMA - Journal of the American Medical Association - April 17, 2024 Category: General Medicine Source Type: research

Accelerating Climate Action Through Academic Health Systems
This Viewpoint makes the case for academic health systems to lead the way on climate change action in the US, including planning to reduce greenhouse gas emissions, educating current and future clinicians, and communicating with their patients and communities. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 17, 2024 Category: General Medicine Source Type: research

Leave of Absence and Medical Student GME Placement by Race and Ethnicity
This study examines the association between taking a leave of absence from medical school and placement into graduate medical education (GME) by race and ethnicity. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 15, 2024 Category: General Medicine Source Type: research

Improving Medical Communication
To the Editor Dr Cappola and Ms Cohen ’s article highlighted the importance of medical communication. The study of communication dates to ancient Greece when Aristotle first studied the rhetoric of Western civilizations. Modern communication scholars draw from this long and rich history, applying theory and praxis to various contexts. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 15, 2024 Category: General Medicine Source Type: research