Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A New Drug Slows Alzheimer ’ s By One-Third (M)
Patients were also 40 percent less likely to progress from mild cognitive impairment to full-blown dementia after taking the drug. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - August 20, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia subscribers-only Source Type: blogs
Associations Between the Lipidome and Epigenetic Aging
The body contains hundreds of different types of lipid molecules, participating in cellular metabolism in ways that are just as complex and relevant to health as the activities of other biomolecules. In the context of aging, this broad range of lipids are perhaps understudied in comparison to levels and roles of proteins and patterns of gene expression. The situation is much the same, however: researchers can readily and cost-effectively amass a vast amount of data, but the analysis of this data lags far behind the accumulation of ever more and ever larger omics databases. It is ever unclear as to whether any particular as...
Source: Fight Aging! - August 18, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Deep Learning for Medical Imaging: Use Cases and Network Types
Conclusion
Medical image analysis solutions powered by deep learning technologies can reduce the risk of diagnostic errors and ensure timely interventions. But how to implement such a tool successfully? The key to successful deployment is cooperation with an experienced machine-learning solutions provider. Professional technical experts will help you choose an optimal architecture for your clinic’s specific goals and ensure effective model training.
About Mariia Kovalova
Mariia Kovalova is a Healthcare Technology Researcher at Itransition, a custom software development company headquartered in Denver, CO. Having work...
Source: EMR and HIPAA - August 18, 2023 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Health IT Company Healthcare IT CNN Convolutional Neural Networks Deep Learning GAN Generative Adversarial Networks Healthcare AI Healthcare Neural Networks Itransition MADGAN Mariia Kovalova Medical Imaging Source Type: blogs
Hopes and Questions raised by Alzheimer ’s drug Leqembi (lecanemab)
The FDA has approved Leqembi, the first disease-modifying treatment for early-stage Alzheimer’s and a precursor condition, mild cognitive impairment. Medicare has said it will pay for the therapy. Medical centers across the country are scrambling to finalize policies and procedures for providing the medication to patients, possibly by summer’s end or early autumn.
It’s a fraught moment, with hope running high for families and other promising therapies such as donanemab on the horizon. Still, medical providers are cautious. “This is an important first step in developing treatments for complex neurodegenerative disea...
Source: SharpBrains - August 17, 2023 Category: Neuroscience Authors: Judith Graham at Kaiser Health News Tags: Brain/ Mental Health cognition early-stage Alzheimer’s Eisai FDA lecanemab Leqembi Medicare mild-cognitive-impairment Source Type: blogs
Treating a Mouse Model of Alzheimer's Disease with Hematopoietic Stem Cell Transplantation
Overly reactive, senescent, and otherwise inflammatory microglia in the brain are implicated in the development of neurodegenerative conditions. Chronic inflammation in brain tissue disrupts neural function in numerous ways. Thus why not clear or replace microglia? There are established ways to remove these cells, allowing them to regenerative over a few weeks, but these have not yet made their way to human trials for neurodegenerative conditions, despite interesting results in animal models. The replacement of microglia via transplantation of hematopoietic cells is at a similar stage, wherein there are interesting results...
Source: Fight Aging! - August 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Top 6 Companies Using AI In Drug Discovery And Development
What if coming up with a new drug could be measured in days rather than years? What if new medication would cost thousands instead of billions of dollars? Just look at how an AI pharma start-up developed a potential new drug in 46 days! Artificial intelligence technologies promise to speed up the process of drug discovery and development and make it more cost-effective. As the market is flourishing, and it takes time and effort to separate the wheat from the chaff, we collected the most promising AI pharma companies out there.
Drug design is a key area AI is revolutionizing. In one of our latest database projects, we de...
Source: The Medical Futurist - August 17, 2023 Category: Information Technology Authors: berci.mesko Tags: Artificial Intelligence in Medicine Future of Pharma Genomics research clinical trials AI drug development medication drug discovery drug research cure Source Type: blogs
Fight Aging! Newsletter, August 14th 2023
This study demonstrates just how vital the thymus is to maintaining adult health."
« Back to Top
Does Amyloid-β Aggregation Cause Broad Disruption of Proteostasis?
https://www.fightaging.org/archives/2023/08/does-amyloid-%ce%b2-aggregation-cause-broad-disruption-of-proteostasis/
Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn't ...
Source: Fight Aging! - August 13, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Best Type Of Exercise To Prevent Alzheimer ’ s Disease (M)
The exercise is anti-inflammatory and reduces levels of stress hormones. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - August 11, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia subscribers-only Source Type: blogs
Does Amyloid- β Aggregation Cause Broad Disruption of Proteostasis?
Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn't necessarily show that it has a sizable effect in mammals. Still, it is an interesting concept, potentially linking everything we know about why amyloid-β increases with age to the observed general dysfunction of brain cells.
Loss of proteostasis is a highly conserved feature of aging across model organisms...
Source: Fight Aging! - August 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Senolytic Vaccine Targeting SAGP Reduces Pathology in a Mouse Model of Alzheimer's Disease
In this study, the research team created an Alzheimer's disease mouse model that mimics a human brain and simulates amyloid-beta-induced Alzheimer's disease pathology. To test the efficacy of the SAGP vaccine, the mice were treated with a control vaccine or the SAGP vaccine at two and four months old. Usually, people in the late stage of Alzheimer's lack anxiety, which means they are not aware of the things around them. The mice who received the vaccine had anxiety, which means that they were more cautious and more aware of things around them - a sign researcher say could indicate a lessening of the disease. In addition, s...
Source: Fight Aging! - August 8, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Blood Protein Signature of Increased Dementia Risk
The search for ways to determine whether someone is in the very early stages of developing dementia overlaps with the development of means to determine biological age. The first step in both cases is to gather a sizable database of omics data, usually from blood samples. Once that data is in hand, why not try to achieve both goals? Alzheimer's disease and other neurodegenerative conditions may exhibit years to decades of slow development prior to evident symptoms, and those underlying processes will show up given the right measurements. The research noted here is one example of the exploration of biomarkers that is present...
Source: Fight Aging! - August 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Can Hallucinated AI Help with Patient Engagement?
The following is a guest article by Michelle X. Zhou, Ph.D., Co-Founder and CEO at Juji
ChatGPT and similar AI applications have given humankind a new tool. While this new tool is powerful, it may not always be reliable. Hence the term “AI hallucinations” is coined to refer to such unreliable AI performance.
Here is an example. I asked ChatGPT, “Who founded Juji“, the AI startup I co-founded. It hallucinated with the following reply:
It got several facts wrong including my education. I received my Ph.D. from Columbia University, not Carnegie Mellon University. Moreover, Juji was co-founded by Dr. H...
Source: EMR and HIPAA - August 7, 2023 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning C-Suite Leadership Clinical Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System AI Chatbot ChatGPT Dr. Huahai Yang Generative AI Healthcare AI Hallucinations Healthcare Source Type: blogs
Stimulating the Olfactory System as a Way to Improve Late Life Cognitive Function
The research noted here adds to evidence for the lack of use of the senses to contribute to age-related declines in cognitive function: a sort of "use it or lose it" proposition for the brain that becomes especially pronounced in later life. This effect is better studied in the context of age-related deafness, given the sizable amount of data on hearing aid use. Here, however, researchers focus on the sense of smell, and find that cognitive function can be improved by stimulation via scents.
When a fragrance wafted through the bedrooms of older adults for two hours every night for six months, memories skyrocketed....
Source: Fight Aging! - August 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
