Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reducing Cardiovascular Risk Factor Also Reduces Incidence of Neurodegenerative Disease
It is well known that the aging of the vasculature contributes to the aging of the brain. The brain requires a great deal of energy to operate, and the nutrients and oxygen needed for optimal brain metabolism are supplied in the bloodstream. With age, capillary density declines, the heart becomes weaker, and blood vessels are narrowed by the development of atherosclerotic lesions. All of this combines to reduce the delivery of nutrients to the brain, and its metabolism suffers as a result. Here, researchers present additional evidence to support this view of the impact of cardiovascular aging on brain aging.
Cardi...
Source: Fight Aging! - September 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
PU.1 Inhibition to Reduce Microglial Inflammation in the Aging Brain
Researchers here report on a drug discovery effort targeting PU.1, a gene implicated in increased inflammation of microglia in the brain. Microglia are innate immune cells of the central nervous system. Like macrophages in the rest of the body, they react to the damage and dysfunction of aging with increased inflammatory behavior, a maladaptive response that worsens pathology. Chronic, unresolved inflammation is clearly disruptive to tissue function wherever it occurs in the body. In the brain, chronic inflammation is a well-studied feature of conditions such as Alzheimer's disease. A greater population of inflammatory mic...
Source: Fight Aging! - September 6, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Very Popular Food Linked To Brain Shrinkage
The shrinkage is linked to developing Alzheimer's disease or another type of dementia. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - September 3, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Source Type: blogs
Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men.
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Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis
https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/
Neurogenesis is the process by which new neurons are created by neural stem c...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis
We examined whether adult neurogenesis sustains hippocampal connections cumulatively across the life span. Long-term suppression of neurogenesis as occurs during stress and aging resulted in an accelerated decline in hippocampal acetylcholine signaling and a slow and progressing emergence of profound working memory deficits.
These deficits were accompanied by compensatory reorganization of cholinergic dentate gyrus inputs with increased cholinergic innervation to the ventral hippocampus and recruitment of ventrally projecting neurons by the dorsal projection. While increased cholinergic innervation was dysfunctional...
Source: Fight Aging! - September 1, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Declining Cardiovascular Mortality in Atrial Fibrillation Patients
A downward trend in cardiovascular mortality has prevailed for some time now, and we might take the data here as an example of ways in which improved options for detection and treatment produce results in specific portions of the patient population. Also worthy of note is the point that these older patients have many issues, and while slowing the pace of cardiovascular decline with age should have beneficial effects throughout the body, reduced cardiovascular mortality due to improved treatment that specifically focuses on cardiovascular disease allows other age-related conditions to claim a greater proportion of the popul...
Source: Fight Aging! - September 1, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Sex Differences in Microglial Senescence in the Context of Alzheimer's Disease
Why are two-thirds of Alzheimer's patients women? Women live longer than men, making up an ever larger share of the surviving cohort at any given age, and Alzheimer's is an age-related disease. This doesn't explain the whole of the difference, however. A dominant hypothesis is that the immune system is sufficiently different between the sexes to produce marginally greater dysfunction and neuroinflammation in women, in the same way that still incompletely understood biochemical differences lead to a greater incidence of autoimmunity in women. Researchers here produce supporting evidence for this hypothesis, showing that fem...
Source: Fight Aging! - August 31, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Intermittent Fasting Reduces Pathology in a Mouse Model of Alzheimer's Disease
The sizable body of work produced on calorie restriction and fasting over the last twenty years is supportive of the hypothesis that time spent hungry is an important factor determining the scale of benefits to health and longevity. The cellular response to a transient lack of nutrients involves improved cell maintenance, such as upregulation of autophagy to clear out damaged and worn molecular machinery. Looking at a level of organization above the cell, a transient state of hunger likely produces many other benefits to the way in which complex tissues and relationships between tissues function in the body. It dampens inf...
Source: Fight Aging! - August 30, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Meninges at the Border Between the Brain Immune System and the Peripheral Immune System
While the immune system of the brain is distinct from that of the rest of the body, the central nervous system walled off by the blood-brain barrier, the inflammatory status of the brain is very much influenced by the inflammatory status of the rest of the body. Signals pass back and forth, and at the edges of the brain there are a variety of tissues in which one can find peripheral immune cells such as macrophages of the innate immune system or T cells of the adaptive immune system.
One such tissue is the meninges, the membranes that wrap the brain and spinal cord. In recent years, since the discovery of the glymph...
Source: Fight Aging! - August 28, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
More Evidence for Vaccination to Reduce Alzheimer's Disease Risk
There is good evidence for the various forms of later life vaccination, such as for herpes zoster or influenza, to reduce the risk of later suffering Alzheimer's disease. One possibility is that people who take the time to obtain a vaccine tend to take better care of their health across the board. Another possibility is that vaccination produces a trained immunity effect that dampens age-related inflammation for a sustained period of time. It may also be the case that suffering from influenza, pneumonia, or similar infectious diseases causes sufficient additional inflammation to move the odds on suffering later neurodegene...
Source: Fight Aging! - August 28, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan.
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Trials of Xenotransplantation of Pig Organs into Humans Continue
https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants i...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
T Cell Dysfunction in Neurodegenerative Conditions
Chronic inflammation and dysfunction of immune cells is a characteristic of neurodegenerative conditions. Attention is usually given to the innate immune cells of the central nervous system in this context, but it is also the case that the adaptive immune system outside the brain tends towards dysfunction in older individuals suffering from age-related disease. Researchers here review what is known of T cell exhaustion, senescence, and other issues in older individuals. It is hoped that clearing these problematic cells from the immune population, such as via the use of senolytic drugs to destroy senescent cells, will have ...
Source: Fight Aging! - August 25, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Personality Change Like This May Signal Dementia
The personality changes came ahead of more obvious behavioural changes linked to Alzheimer's. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - August 23, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Source Type: blogs
This Sleep Pattern Accelerates Memory Loss – Possible Link to Alzheimer ’ s
Sleep pattern lowered levels of an antioxidant that helps fight cellular damage, such as that caused by Alzheimer's. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - August 23, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Memory Sleep Source Type: blogs
