The effects of cool roofs on health, environmental, and economic outcomes in rural Africa: study protocol for a community-based cluster randomized controlled trial
DiscussionOur study demonstrates the potential of large-scale cRCTs to evaluate novel climate change adaptation interventions and provide evidence supporting investments in heat resilience in sub-Saharan Africa. By conducting this research, we will contribute to better policies and interventions to help climate-vulnerable populations ward off the detrimental effects of extreme indoor heat on health.Trial registrationGerman Clinical Trials Register (DRKS) DRKS00023207. Registered on April 19, 2021. (Source: Trials)
Source: Trials - January 16, 2024 Category: Research Source Type: clinical trials
Antiretrovirals Combined With Antibodies for HIV-1 Cure In Africa
Conditions: HIV-1-infection Interventions: Drug: 3BNC117-LS; Drug: 10-1074-LS; Drug: Placebo for 3BNC117-LS; Drug: Placebo for 10-1074-LS Sponsors: AIDS Clinical Trials Group; National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 15, 2024 Category: Research Source Type: clinical trials
Improving HIV Prevention Among Heterosexual Cisgender Men Seeking STI Services in Sub-Saharan Africa
Conditions: HIV Infection; Sexually Transmitted Infections; Pre-exposure Prophylaxis; Systems Navigation Interventions: Other: PrEP eligibility assessment; Diagnostic Test: Rapid HIV antibody testing prior to provision and/or refill of PrEP; Other: PrEP follow-up with a PrEP nurse in accordance with contemporary PrEP guidelines; Behavioral: Evaluation of barriers and facilitators to ongoing PrEP use; Other: Point of contact STI testing to inform counseling regarding ongoing PrEP care engagement; Other: Tracing for any missed PrEP visits; Other: Offering a PrEP " restart " kit for cisgender men who choose to discontinue PrE...
Source: ClinicalTrials.gov - January 11, 2024 Category: Research Source Type: clinical trials
Effect Of Health Extension Worker-Led Based Interventions on Improving Self-Management Behavior Among Diabetic Patients in Ethiopia
Conditions: Diabetes Mellitus, Self-management Behavior and Glycosylated Hemoglobin Levels Interventions: Behavioral: Health Extension Led club based Intervention Sponsors: Debre Berhan University; University of South Africa Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 3, 2024 Category: Research Source Type: clinical trials
YoPA - A Youth-centred Participatory Action
Conditions: Physical Activity; Health Promotion; Sleep Interventions: Other: Social and/or physical environmental interventions Sponsors: Amsterdam UMC, location VUmc; Stichting Alexander (the Netherlands); Syddansk Universitet, Denmark; Aalborg Kommune (Denmark); University of the Witwatersrand Johannesburg (South Africa); WITS Health Consortium (South Africa); Redeemer ' s University (Nigeria); Value Re-Orientation for Community Enhancement (Nigeria); Instituut voor Tropische Geneeskunde, Belgium; COFAC Cooperativa de Formacao e Animacao Cultural CRL (Portugal) Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 25, 2023 Category: Research Source Type: clinical trials
Identifying and Addressing Barriers to Retention in the Cervical Cancer Treatment Cascade Among Women With HIV in South Africa
Conditions: Cervical Cancer; Hiv Interventions: Behavioral: Retention in cervical cancer care intervention Sponsors: Boston University Charles River Campus; University of Witwatersrand, South Africa Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 25, 2023 Category: Research Source Type: clinical trials
STREngthening COVID-19 Surveillance in Africa
Conditions: COVID-19; SARS CoV 2 Infection; COVID-19 Pandemic Sponsors: Institut de Recherche pour le Developpement; European and Developing Countries Clinical Trials Partnership (EDCTP); Institut de Recherche Clinique du B énin; Barcelona Institute for Global Health; Ministère de la Santé - Bénin; Ministère de la Santé et de Hygiène Publique - Burkina Faso Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 14, 2023 Category: Research Source Type: clinical trials
E-cigarette Harm Reduction Among PLWHA in South Africa
Conditions: Tobacco Smoking Interventions: Other: Nicotine Replacement Therapy (NRT); Other: E-Cigarette (EC); Behavioral: Counseling Sponsors: NYU Langone Health; JOHN E FOGARTY INTERNATIONAL CENTER FOR ADVANCED STUDY IN THE HEALTH SCIENCES (FIC) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 14, 2023 Category: Research Source Type: clinical trials
STREngthening COronavirus Disease 2019 (COVID-19) Surveillance in Africa
Conditions: COVID-19; SARS CoV 2 Infection; COVID-19 Pandemic Sponsors: Institut de Recherche pour le Developpement; European and Developing Countries Clinical Trials Partnership (EDCTP); Institut de Recherche Clinique du B énin; Barcelona Institute for Global Health; Ministère de la Santé - Bénin; Ministère de la Santé et de Hygiène Publique - Burkina Faso Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 14, 2023 Category: Research Source Type: clinical trials
Positive Deviance to Improve Retention in HIV Care HIV Care in South Africa
Conditions: Hiv Interventions: Behavioral: Connect Sponsors: RAND; National Institute of Mental Health (NIMH); University of Stellenbosch; Western Cape Department of Health and Wellness Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 5, 2023 Category: Research Source Type: clinical trials
Tranexamic acid by the intramuscular or intravenous route for the prevention of postpartum haemorrhage in women at increased risk: a randomised placebo-controlled trial (I ’M WOMAN)
DiscussionThe trial will provide evidence of the benefits and harms of TXA for PPH prevention and the effects of the IM and IV routes of administration. The IM route should be as effective as the IV route for preventing bleeding. There may be fewer side effects with IM TXA because peak blood concentrations are lower than with the IV route. IM TXA also has practical advantages as it is quicker and simpler to administer. By avoiding the need for IV line insertion and a slow IV injection, IM administration would free up overstretched midwives and doctors to focus on looking after the mother and baby and expand access to timel...
Source: Trials - December 3, 2023 Category: Research Source Type: clinical trials
Africa Ready Malaria Screening
Conditions: Malaria Interventions: Diagnostic Test: Immuno analytical assay Sponsors: University of Ghana; Shai-Osudoku District Hospital; Kumasi Technical University; University of Rostock; University of Applied Sciences Bonn-Rhein-Sieg; Hochschule Aalen Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 1, 2023 Category: Research Source Type: clinical trials
Investigation of Immune Amnesia Following Measles Infection in Select African Regions
Conditions: Measles Infection Interventions: Biological: Verorab Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); Johns Hopkins University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 1, 2023 Category: Research Source Type: clinical trials
Adaptive evaluation of mHealth and conventional adherence support interventions to optimize outcomes with new treatment regimens for drug-resistant tuberculosis and HIV in South Africa (ADAP-TIV): study protocol for an adaptive randomized controlled trial
DiscussionThis trial will evaluate the contribution of different modes of adherence support on MDR-TB and HIV outcomes with WHO-recommended all-oral MDR-TB regimens and ART in a high-burden operational setting. We will also assess the utility of a DSD framework to pragmatically adjust levels of MDR-TB and HIV treatment support.Trial registrationClinicalTrials.gov NCT05633056. Registered on 1 December 2022 (Source: Trials)
Source: Trials - December 1, 2023 Category: Research Source Type: clinical trials
SCHISTOACT: a protocol for an open-label, five-arm, non-inferiority, individually randomized controlled trial of the efficacy and safety of praziquantel plus artemisinin-based combinations in the treatment of Schistosoma mansoni infection
This study assesses a strategy for repurposing artemisinin-based combination therapies (ACTs) for treating schistosomiasis. It adopts a head-to-head comparison of four different ACTs to test a non-inferiority hypothesis and to strengthen local capacity to conduct clinical trials for interventions against neglected tropical diseases.Trial registrationPan-African Clinical Trials RegistryPACTR202001919442161. Retrospectively registered on 6 January 2020 (Source: Trials)
Source: Trials - November 27, 2023 Category: Research Source Type: clinical trials
