Acceptability and Feasibility of Injectable Cabotegravir Pre-exposure Prophylaxis (PrEP) Versus Oral PrEP in Routine Care up to 15 Months in Private Pharmacies in South Africa
Conditions: HIV Infections Interventions: Drug: Cabotegravir Injection [Apretude]; Drug: Tenofovir disoproxil fumarate / emtricitabine (or lamivudine) Sponsors: University of Witwatersrand, South Africa; ViiV Healthcare; Bill and Melinda Gates Foundation Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 18, 2023 Category: Research Source Type: clinical trials
Vaginal lIve Biotherapeutic RANdomized Trial
Conditions: Bacterial Vaginosis Interventions: Drug: LC106; Drug: LC115; Drug: Placebo; Drug: Metronidazole Oral Sponsors: Massachusetts General Hospital; Bill and Melinda Gates Foundation; Ragon Institute of MGH, MIT and Harvard; Centre for the AIDS Programme of Research in South Africa Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 16, 2023 Category: Research Source Type: clinical trials
Implementing Oral (Event-driven and Daily) and Long-acting Pre-Exposure Prophylaxis in Mobile Men in Sub-Saharan Africa
Conditions: HIV Interventions: Drug: Tenofovir disoproxil fumarate/emtricitabine (TDF-FTC), cabotegravir (CAB-LA); Drug: Cabotegravir (CAB-LA), Tenofovir disoproxil fumarate/emtricitabine (TDF-FTC) Sponsors: MRC/UVRI and LSHTM Uganda Research Unit; King ' s College London; London School of Hygiene and Tropical Medicine; Africa Health Research Institute; Wits Health Consortium (Pty) Ltd; University College, London; Ministry of Health, Uganda; Desmond Tutu HIV Foundation; Assistance Publique - H ôpitaux de Paris Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 15, 2023 Category: Research Source Type: clinical trials
A Pilot Study for Adaptation of Neospot Device for Health Care at Primary Health Facilities in Kenya
Conditions: Morbidity Interventions: Device: Neospot vitals measurement Sponsors: Neopenda, PBC; Amref Health Africa Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 15, 2023 Category: Research Source Type: clinical trials
Genital Tract Infections, the Vaginal Microbiome and Gestational Age at Birth Among Pregnant Women in South Africa
Conditions: Sexually Transmitted Infections (Not HIV or Hepatitis); Premature Birth; Pregnancy; Infection; Microbial Colonization; Chlamydia Trachomatis Infection; Neisseria Gonorrheae Infection; Trichomonas Vaginitis; Mycoplasma Genitalium Infection; Bacterial Vaginosis; Vaginal Candida; Ureaplasma Urealyticum Infection; Genital Mycoplasma Infection; HIV Infections Interventions: Other: No intervention Sponsors: University of Bern; Foundation for Professional Development; Utrecht University; University of Pretoria; University of Cape Town; University of Southern California; University of Alabama at Birmingham; Louisiana S...
Source: ClinicalTrials.gov - November 14, 2023 Category: Research Source Type: clinical trials
Peer PrEP referral + HIV self-test delivery for PrEP initiation among young Kenyan women: study protocol for a hybrid cluster-randomized controlled trial
DiscussionEvidence from this trial will help us understand how HIVST could support health systems by facilitating linkage to PrEP services among young women who could benefit in Kenya and similar settings.Trial registrationClinicalTrials.gov NCT04982250. Registered on July 29, 2021. (Source: Trials)
Source: Trials - November 4, 2023 Category: Research Source Type: clinical trials
EaveTubes for control of vector-borne diseases in C ôte d’Ivoire: study protocol for a cluster randomized controlled trial
DiscussionFindings will serve as an efficacy trial of ETs and will be submitted to the WHO Vector Control Advisory Group (VCAG) for assessment of public health value. Entomological outcomes will also be measured as proxies of malaria transmission to help develop guidelines for the evaluation of future In2Care ® ETs products.Trial registrationClinicalTrials.gov NCT05736679. Registered on 10 February 2023. (Source: Trials)
Source: Trials - November 2, 2023 Category: Research Source Type: clinical trials
Prevalence of Irritable Bowel Syndrome in Medical Students Africa
Conditions: Faculty of Medicine Sponsors: Assiut University; AsyutUniversity Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 24, 2023 Category: Research Source Type: clinical trials
Community-based type 2 diabetes care by lay village health workers in rural Lesotho: protocol for a cluster-randomized trial within the ComBaCaL cohort study (ComBaCaL T2D TwiC)
DiscussionThe trial was launched on May 13, 2023, and has enrolled 226 participants at the date of submission (October 6, 2023). To our knowledge, the trial is the first to assess task-shifting of T2D care to VHWs at the community level, including the prescription of first-line antidiabetic, lipid-lowering, and antiplatelet medication in sub-Saharan Africa, and will thus provide the missing evidence on the effectiveness of such a T2D care model in this setting. The study is operating within the established Lesotho VHW programme. Similar community health worker programmes which exist across sub-Saharan Africa may benefit fr...
Source: Trials - October 24, 2023 Category: Research Source Type: clinical trials
An Adolescent Health and Wellbeing Check-up Programme in Three African Cities (Y-Check)
Conditions: Adolescent Development; Adolescent Behavior; Health-Related Behavior; Health Care Seeking Behavior Interventions: Other: Screening package; Diagnostic Test: Psychosocial and mental health disorder screening; Diagnostic Test: Alcohol, tobacco and substance use screening; Behavioral: Diet and physical activity screening; Diagnostic Test: Underweight and overweight screening; Diagnostic Test: Anemia; Behavioral: Oral health screening; Behavioral: Circumcision screening; Behavioral: Risky behaviours; Diagnostic Test: HIV testing; Diagnostic Test: STI (CT, NG, TV) testing; Behavioral: Immunization screening; Diagnos...
Source: ClinicalTrials.gov - October 19, 2023 Category: Research Source Type: clinical trials
Safety and PK Multi-dose Study of TAF/EVG Vaginal Insert
Conditions: Safety Issues Interventions: Drug: TAF/EVG vaginal insert; Drug: Matching Placebo vaginal insert Sponsors: Eastern Virginia Medical School; CONRAD; University of Pittsburgh; Centre for the AIDS Programme of Research in South Africa; Kenya Medical Research Institute; United States Agency for International Development (USAID) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 18, 2023 Category: Research Source Type: clinical trials
Mindful Walking Program for Older African Americans
Conditions: Cognitive Function; Aging Well; Behavior, Health Interventions: Behavioral: Mindful walking activity Sponsors: University of South Carolina; Centers for Disease Control and Prevention Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 16, 2023 Category: Research Source Type: clinical trials
Multiple Micronutrient Supplementation for Maternal Anemia Prevention in Tanzania
Conditions: Pregnancy Related Interventions: Dietary Supplement: Multiple Micronutrient Supplements with 30 mg of elemental iron; Dietary Supplement: Multiple Micronutrient Supplements with 45 mg of elemental iron; Dietary Supplement: Multiple Micronutrient Supplements with 60 mg of elemental iron Sponsors: George Washington University; Ifakara Health Institute; Harvard School of Public Health (HSPH); Muhimbili University of Health and Allied Sciences; Africa Academy for Public Health; Columbia University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 12, 2023 Category: Research Source Type: clinical trials
A Mobile Health (mHealth) Strategy for Improving Blood Pressure Control Among Adult Hypertensive African Americans
Conditions: Hypertension; Blood Pressure Interventions: Other: USeeBP Sponsors: University of Chicago Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 12, 2023 Category: Research Source Type: clinical trials
Multiple Micronutrient Supplementation for Maternal Anemia Prevention in Tanzania ( MMS-MAP )- MMS Iron Dose Trial
Conditions: Pregnancy Related Interventions: Dietary Supplement: Multiple Micronutrient Supplements with 30 mg of elemental iron; Dietary Supplement: Multiple Micronutrient Supplements with 45 mg of elemental iron; Dietary Supplement: Multiple Micronutrient Supplements with 60 mg of elemental iron Sponsors: George Washington University; Ifakara Health Institute; Harvard School of Public Health (HSPH); Muhimbili University of Health and Allied Sciences; Africa Academy for Public Health; Columbia University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 6, 2023 Category: Research Source Type: clinical trials
