Fight Aging! Newsletter, April 8th 2024
In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth factors, cytoskeletal remodeling factors, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls.
Secretome delivery substantially increased whole-body lean mass and decreased fat mass, corresponding to higher myofiber cross-sectional area and smaller adipocyte size, respectively. Secretome-treated mice also had greater whole-bod...
Source: Fight Aging! - April 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Naked Mole Rats are Resistant to Ischemia, Such as Occurs Following a Heart Attack
On the one hand, naked mole-rats are most likely long-lived because they live underground, and thus suffer much lower rates of predation than other similarly sized mammals. Lower rates of extrinsic mortality appear to be a necessary prerequisite for the evolution of a longer species life span. On the other hand, living in a low-oxygen environment appears to have spurred the evolution of broad range of adaptations to that environment that incidentally happen to extend species longevity. Today's open access paper covers one aspect of those adaptations, a resistance to ischemia that reduces the harms resulting from the loss o...
Source: Fight Aging! - April 5, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Where ’s Our Infrastructure Plan B?
By KMI BELLARD
I’ve been thinking a lot about infrastructure. In particular, what to do when it fails.
There was, of course, the tragic collapse of Baltimore’s Francis Scott Key Bridge. Watching the video – and, honestly, what were the odds there’d be video? — is like watching a disaster movie, the bridge crumbling slowly but unstoppably. The bridge had been around for almost fifty years, withstanding over 11 million vehicles crossing it each year. All it took to knock it down was one container ship.
Container ships passed under it every day of its existence; the Port of Baltimore is one of the busie...
Source: The Health Care Blog - April 3, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Bridges Change Healthcare GPS Infrastructure Internet Cables Kim Bellard Source Type: blogs
Case of the Week 742
This week ' s case features another beautiful example of microfilariae in blood. The patient is from sub-Saharan Africa and presents with chronic swelling of his left leg. The microfilariae measure approximately 270 µm in length. Carazzi stain (Knott ' s concentration):Giemsa Stain (thick blood film)What is your identification? What time should blood be collected for this examination? (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - March 26, 2024 Category: Parasitology Source Type: blogs
Are AI Clinical Protocols A Dobb-ist Trojan Horse?
By MIKE MAGEE
For most loyalist Americans at the turn of the 19th century, Justice John Marshall Harlan’s decision in Jacobson v. Massachusetts (1905). was a “slam dunk.” In it, he elected to force a reluctant Methodist minister in Massachusetts to undergo Smallpox vaccination during a regional epidemic or pay a fine.
Justice Harlan wrote at the time: “Real liberty for all could not exist under the operation of a principle which recognizes the right of each individual person to use his own, whether in respect of his person or his property, regardless of the injury that may be done to others.”
What could ...
Source: The Health Care Blog - March 1, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Abortion AI Dobbs Forced Sterilization Mike Magee racial bias SCOTUS Vaccination Source Type: blogs
Developing Low-Cost Lab Techniques: Q & A With Abraham Badu-Tawiah
Credit: Ohio State University.
“I never thought I could make an impact on chemistry and students’ lives. But now, I’m the head of a lab with several Ph.D. and undergraduate students and a postdoctoral researcher; and we’re developing simple, low-cost lab techniques that can be adopted by labs across the world,” says Abraham Badu-Tawiah, Ph.D., the Robert K. Fox Professor of Chemistry at Ohio State University in Columbus. We talked with Dr. Badu-Tawiah about his career progression, research, and advice for students hoping to launch a career in science.
Q: How did you get started on the path to a career in sci...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 21, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Tools and Techniques Profiles Source Type: blogs
The 7 Decade History of ChatGPT
By MIKE MAGEE
Over the past year, the general popularization of AI orArtificial Intelligence has captured the world’s imagination. Of course, academicians often emphasize historical context. But entrepreneurs tend to agree with Thomas Jefferson who said, “I like dreams of the future better than the history of the past.”
This particular dream however is all about language, its standing and significance in human society. Throughout history, language has been a species accelerant, a secret power that has allowed us to dominate and rise quickly (for better or worse) to the position of “masters of the un...
Source: The Health Care Blog - February 19, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech AI ChatGPT History of AI Mike Magee Source Type: blogs
A Medical Countermeasures Platform for Future Pandemics: Essential Elements for Equity
Fifa Rahman (Health Poverty Action), Onesmus Kalama (Eastern Africa National Network of AIDS and Health Services Organization), Samantha Rick (AVAC), Arush Lal (Chatham House), et al., A Medical Countermeasures Platform for Future Pandemics: Essential Elements for Equity (Ne. Univ. Sch.... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - February 17, 2024 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Fight Aging! Newsletter, February 12th 2024
In conclusion, frailty is a dynamic process, and improved frailty and remaining robust are significantly associated with lower risk of all-cause mortality and cardiovascular death in older people.
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Greater Individual Wealth Correlates with Longer Life Expectancy
https://www.fightaging.org/archives/2024/02/greater-individual-wealth-correlates-with-longer-life-expectancy/
Individual wealth correlates with life expectancy, with an effect size that is in the same ballpark as those related to lifestyle choices involving exercise, diet, and consequences thereof. It remains unclear...
Source: Fight Aging! - February 11, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Broadening Opportunities for Students in STEM at Brown University and Beyond
Credit: Courtesy of Brown University.
Andrew G. Campbell, Ph.D., a professor of medical science at Brown University in Providence, Rhode Island, and previous dean of the graduate school, is passionate about researching understudied diseases and helping students reach their full potential.
Dr. Campbell’s lab has studied the single-cell organism Trypanosoma brucei (T. brucei), a parasite transmitted through the bite of the tsetse fly, which is only found in specific regions of Africa. In humans, T. brucei causes African Trypanosomiasis, also known as sleeping sickness. Symptoms of this illness include headache, weakne...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 8, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist STEM Education Profiles Training Source Type: blogs
Increasing Opportunities in STEM at Brown University and Beyond
Credit: Courtesy of Brown University.
Andrew G. Campbell, Ph.D., a professor of medical science at Brown University in Providence, Rhode Island, and previous dean of the graduate school, is passionate about researching understudied diseases and helping students reach their full potential.
Dr. Campbell’s lab has studied the single-cell organism Trypanosoma brucei (T. brucei), a parasite transmitted through the bite of the tsetse fly, which is only found in specific regions of Africa. In humans, T. brucei causes African Trypanosomiasis, also known as sleeping sickness. Symptoms of this illness include headache, weakne...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 7, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist STEM Education Profiles Training Source Type: blogs
An Interview with Karl Pfleger
Karl Pfleger is one of the more prolific angel investors in the longevity industry. Naturally he is an investor in Repair Biotechnologies, the company that I co-founded with Bill Cherman and which is currently focused on a gene therapy approach to reversal of atherosclerosis. In addition to his investment and conference-going activities, Pfleger runs the very useful Aging Biotech Info resource, which has expanded from the starting point of a list of companies in the longevity industry to its present state of listing of a great many more items: conferences, books, blogs, interventions, diagnostics, and so forth. In the podc...
Source: Fight Aging! - February 5, 2024 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
The Money ’ s in the Wrong Place. How to Fund Primary Care
By MATTHEW HOLT
I was invited on the Health Tech Talk Show by Kat McDavitt and Lisa Bari and I kinda ranted (go to 37.16 here) about why we don’t have primary care, and where we should find the money to fix it. I finally got around to writing it up. It’s a rant but a rant with a point!
We’re spending way too much money on stuff that is the wrong thing.
30 years ago, I was taught that we were going to have universal health care reform. And then we were going to have capitated at-risk entities. then below that, you have all these tech enabled services, which are going to make all this stuff work an...
Source: The Health Care Blog - February 5, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Matthew Holt ACA ACO CVS FQHCs Health Systems hedge funds Hospitals Medisync primary care Walgreens Walmart Source Type: blogs
Book review: Your Pain Playbook by Helen Roome
There is an enormous missing link in pain management today. That link is, as I see it, how to translate from theory (decontextualised ideas) to daily life. To my life, to your life, to the unique and varied lives people living with pain had before their pain arrived.
Your Pain Playbook is written by Helen Roome, pain occupational therapist living and working in South Africa. The South African vibe runs through her book, giving this Kiwi a lovely taste of Helen’s country via the metaphors she uses – ever heard of the ‘Go-away bird’? It’s a bird that warns impala of impending danger and Hele...
Source: HealthSkills Weblog - January 28, 2024 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Book reviews, site reviews Coping strategies Chronic pain Occupational therapy pain management Source Type: blogs
Major research papers from NEJM in 2023
Here is a pleasant surprise, a collectors issue of NEJM year book 2023, is made available free (even for a non subscribers in its website) .It is fascinating to know how fast the Internal medicine has grown. For the busy cardiologists, this will a be refreshing reminder, that there are other important organs and specialties do exist in medicine , with equal breakthroughs and Innovations.
It is indeed an amazing , whirlwind tour of medicine for all those who see medical science as single holistic specialty. It has articles, ranging from from simple clinical studies on postpartum hemorrhage (E-MOTIVE study) from deep ...
Source: Dr.S.Venkatesan MD - January 25, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized 2023 review articles acc aha esc guidlines an Aldosterone synthase antagonist for Treatment-Resistant Hypertension Baxdrostat bmj E MOTIVE STUDY PPH lancet nejm Of-course semaglutide TRUNCATE TB Source Type: blogs
