SCHISTOACT: a protocol for an open-label, five-arm, non-inferiority, individually randomized controlled trial of the efficacy and safety of praziquantel plus artemisinin-based combinations in the treatment of Schistosoma mansoni infection

This study assesses a strategy for repurposing artemisinin-based combination therapies (ACTs) for treating schistosomiasis. It adopts a head-to-head comparison of four different ACTs to test a non-inferiority hypothesis  and to strengthen local capacity to conduct clinical trials for interventions against neglected tropical diseases.Trial registrationPan-African Clinical Trials RegistryPACTR202001919442161. Retrospectively registered on 6 January 2020
Source: Trials - Category: Research Source Type: clinical trials