Comparative Effectiveness and Safety of Generic Versus Brand-Name Fluticasone-Salmeterol to Treat Chronic Obstructive Pulmonary Disease
CONCLUSION: Use of generic and brand-name fluticasone-salmeterol was associated with similar outcomes among patients with COPD treated in routine practice.PRIMARY FUNDING SOURCE: National Heart, Lung, and Blood Institute.PMID:37549393 | DOI:10.7326/M23-0615 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - August 7, 2023 Category: Internal Medicine Authors: William B Feldman Aaron S Kesselheim Jerry Avorn Massimiliano Russo Shirley V Wang Source Type: research
Comparative Effectiveness and Safety of Generic Versus Brand-Name Fluticasone-Salmeterol to Treat Chronic Obstructive Pulmonary Disease
CONCLUSION: Use of generic and brand-name fluticasone-salmeterol was associated with similar outcomes among patients with COPD treated in routine practice.PRIMARY FUNDING SOURCE: National Heart, Lung, and Blood Institute.PMID:37549393 | DOI:10.7326/M23-0615 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - August 7, 2023 Category: Internal Medicine Authors: William B Feldman Aaron S Kesselheim Jerry Avorn Massimiliano Russo Shirley V Wang Source Type: research
Comparative Effectiveness and Safety of Generic Versus Brand-Name Fluticasone-Salmeterol to Treat Chronic Obstructive Pulmonary Disease
CONCLUSION: Use of generic and brand-name fluticasone-salmeterol was associated with similar outcomes among patients with COPD treated in routine practice.PRIMARY FUNDING SOURCE: National Heart, Lung, and Blood Institute.PMID:37549393 | DOI:10.7326/M23-0615 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - August 7, 2023 Category: Internal Medicine Authors: William B Feldman Aaron S Kesselheim Jerry Avorn Massimiliano Russo Shirley V Wang Source Type: research
Comparative Effectiveness and Safety of Generic Versus Brand-Name Fluticasone-Salmeterol to Treat Chronic Obstructive Pulmonary Disease
CONCLUSION: Use of generic and brand-name fluticasone-salmeterol was associated with similar outcomes among patients with COPD treated in routine practice.PRIMARY FUNDING SOURCE: National Heart, Lung, and Blood Institute.PMID:37549393 | DOI:10.7326/M23-0615 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - August 7, 2023 Category: Internal Medicine Authors: William B Feldman Aaron S Kesselheim Jerry Avorn Massimiliano Russo Shirley V Wang Source Type: research
Comparative Effectiveness and Safety of Generic Versus Brand-Name Fluticasone-Salmeterol to Treat Chronic Obstructive Pulmonary Disease
CONCLUSION: Use of generic and brand-name fluticasone-salmeterol was associated with similar outcomes among patients with COPD treated in routine practice.PRIMARY FUNDING SOURCE: National Heart, Lung, and Blood Institute.PMID:37549393 | DOI:10.7326/M23-0615 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - August 7, 2023 Category: Internal Medicine Authors: William B Feldman Aaron S Kesselheim Jerry Avorn Massimiliano Russo Shirley V Wang Source Type: research
Budesonide/formoterol maintenance and reliever therapy versus fluticasone/salmeterol fixed-dose treatment in patients with COPD
Conclusions
This first study of MART in COPD found that budesonide/formoterol MART might be similarly effective to fluticasone/salmeterol fixed-dose therapy in moderate to severe patients with COPD, at a lower daily ICS dosage. Further evidence is needed about long-term safety. (Source: Thorax)
Source: Thorax - April 13, 2023 Category: Respiratory Medicine Authors: Muiser, S., Imkamp, K., Seigers, D., Halbersma, N. J., Vonk, J. M., Luijk, B. H. D., Braunstahl, G.-J., van den Berg, J.-W., Kroesen, B.-J., Kocks, J. W. H., Heijink, I. H., Reddel, H. K., Kerstjens, H. A. M., van den Berge, M. Tags: Thorax Chronic obstructive pulmonary disease Source Type: research
Use of digital measurement of medication adherence and lung function to guide the management of uncontrolled asthma (INCA Sun): a multicentre, single-blinded, randomised clinical trial
Lancet Respir Med. 2023 Mar 21:S2213-2600(22)00534-3. doi: 10.1016/S2213-2600(22)00534-3. Online ahead of print.ABSTRACTBACKGROUND: The clinical value of using digital tools to assess adherence and lung function in uncontrolled asthma is not known. We aimed to compare treatment decisions guided by digitally acquired data on adherence, inhaler technique, and peak flow with existing methods.METHODS: A 32-week prospective, multicentre, single-blinded, parallel, randomly controlled trial was done in ten severe asthma clinics across Ireland, Northern Ireland, and England. Participants were 18 years or older, had uncontrolled as...
Source: Respiratory Care - March 24, 2023 Category: Respiratory Medicine Authors: Elaine Mac Hale Garrett Greene Christopher Mulvey Matshediso C Mokoka Job F M van Boven Breda Cushen Imran Sulaiman Vincent Brennan Patrick J Kerr Richard B Reilly Cian Hughes Brian D Kent David J Jackson Marcus Butler Ian Counihan James Hayes John Faul M Source Type: research
Relationship between medication adherence and self-assessment responses in patients with asthma
Digital inhalers can help patients and healthcare professionals identify poor maintenance medication adherence in patients with asthma. Digihaler integrated inhalers transmit data wirelessly to a smart phone application (App), which allows for inhaler usage tracking. The App includes a voluntary, non-respiratory-specific, daily self-assessment (DSA). The CONNECT2 study (NCT04677959) compared the Digihaler Maintenance and Reliever Digital System (MRDS; fluticasone propionate/salmeterol and albuterol Digihalers) with standard of care (SoC) maintenance and reliever inhalers in participants with asthma. (Source: Journal of All...
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Giselle Mosnaim, Flavia Hoyte, Michael Wechsler, Guilherme Safioti, Katja Sagalovich, Randall Brown, Michael Depietro, Tanisha Hill Source Type: research
Relationship between short-acting beta-agonist use and self-assessment responses in patients with asthma
Digital inhalers have the potential to help improve clinical outcomes by providing information about over-reliance on short-acting beta2-agonist (SABA). Digihaler integrated inhalers transmit data wirelessly to a smart phone application (App), which allows for tracking of inhaler usage. The App includes a voluntary, non-respiratory-specific, daily self-asse ssment (DSA). The 6-month CONNECT2 study (NCT04677959) compared the Digihaler Maintenance and Reliever Digital System (MRDS; fluticasone propionate/salmeterol and albuterol Digihalers) with standard of care (SoC) maintenance and reliever inhalers in participants with ...
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Flavia Hoyte, Giselle Mosnaim, Michael Wechsler, Guilherme Safioti, Katja Sagalovich, Randall Brown, Michael Depietro, Tanisha Hill Source Type: research
Mometasone/Indacaterol/Glycopyrronium (MF/IND/GLY) and MF/IND at Different MF Strengths versus Fluticasone Propionate/Salmeterol Xinafoate (FLU/SAL) and FLU/SAL+ Tiotropium in Patients with Asthma
(Source: Journal of Asthma and Allergy)
Source: Journal of Asthma and Allergy - January 19, 2023 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Implications of treatable traits and treatment choices on exacerbation risk in moderate-severe asthma
Conclusions: Symptom control, BMI and sex contribute to ExR, irrespective of treatment. These scenarios quantify the effect of treatable traits and treatment choices in moderate-severe asthma.Funding: GlaxoSmithKline (Study 215310) (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Yorgancıoglu, A. A., Pavord, I., Brusselle, G., Pitrez, P., Oosterholt, S., Pg, A., Della Pasqua, O. Tags: 05.01 - Airway pharmacology and treatment Source Type: research
Maintenance and reliever therapy with budesonide/formoterol versus fixed dose fluticasone/salmeterol in patients with COPD
Conclusion: This first study of MART in COPD found that budesonide/formoterol MART is similarly effective as fluticasone/salmeterol fixed-dose therapy in moderate-severe COPD patients, at a lower daily inhaled corticosteroid dosage. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Muiser, S., Imkamp, K., Seigers, D., Halbersma, N., Vonk, J., Luijk, B., Braunstahl, G., Van Den Berg, J. W., Kroesen, B., Kocks, J., Heijink, I., Reddel, H., Kerstjens, H., Van Den Berge, M. Tags: 05.01 - Airway pharmacology and treatment Source Type: research
Predicting in vitro lung deposition behavior of combined dry powder inhaler via rheological properties
In conclusion, rheological properties is an effective tool for predicting the deposition behavior of DPI not only in single but also in combined DPIs.PMID:36400254 | DOI:10.1016/j.ejpb.2022.11.012 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 18, 2022 Category: Drugs & Pharmacology Authors: Jiayi Li Sibo Ma Ying Sun Ruxiao Song Baoli Cai Hao Li Ying Chen Xin Zhang Jian Guan Shirui Mao Source Type: research
Objective measurement of adherence to asthma treatment with a maintenance and reliever digital system
Suboptimal adherence to inhaled maintenance therapy is common among patients with asthma. In the Maintenance and Reliever Digital System (MRDS), the Digihaler integrated inhalers (fluticasone propionate/salmeterol [FS] and albuterol Digihalers) transmit data wirelessly to a mobile application, which synchronizes with a Digital Health Platform to store and transfer data to a web-based Dashboard. The 6-month CONNECT2 study (NCT04677959) evaluated the MRDS in comparison with the standard of care (SoC) maintenance and reliever inhalers in participants with asthma aged ≥13 years with suboptimal asthma control (Asthma Control ...
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: G. Mosnaim, F. Hoyte, G. Safioti, R. Brown, T. Li, M. DePietro, T. Hill, M. Wechsler Tags: P100 Source Type: research
Data from a maintenance and reliever digital system support patient –clinician interactions in asthma
In the Maintenance and Reliever Digital System (MRDS), the Digihaler integrated inhalers (fluticasone propionate/salmeterol and albuterol Digihalers) transmit data wirelessly to a mobile application, which transfers data to a web-based Dashboard. The 6-month CONNECT2 study (NCT04677959) evaluated the MRDS in participants aged ≥13 years with suboptimal asthma control (Asthma Control Test score (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: G. Mosnaim, F. Hoyte, G. Safioti, R. Brown, T. Li, M. DePietro, T. Hill, M. Wechsler Tags: P098 Source Type: research
