Population Pharmacokinetics of Single Bolus Dose Fentanyl in Obese Children
CONCLUSIONS: Our data demonstrated higher peak plasma fentanyl concentrations in obese compared to nonobese subjects. Population PK analysis found that FFM was a significant covariate for the central volume of distribution. Model simulation showed dosing of fentanyl in obese children based on TBW resulted in significantly higher peak concentrations than dosing based on FFM. Based on this modeling and the known concentration-effect relationship between fentanyl and adverse effects, our results suggest that bolus dosing of fentanyl in obese children should be based on FFM rather than TBW, particularly for procedures of short...
Source: Anesthesia and Analgesia - October 6, 2023 Category: Anesthesiology Authors: Carol R Okada Thomas K Henthorn Jeannie Zuk Cristina Sempio Genie Roosevelt Amanda G Ruiz Mindy N Cohen Debnath Chatterjee Jeffrey L Galinkin Source Type: research
Population Pharmacokinetics of Single Bolus Dose Fentanyl in Obese Children
CONCLUSIONS: Our data demonstrated higher peak plasma fentanyl concentrations in obese compared to nonobese subjects. Population PK analysis found that FFM was a significant covariate for the central volume of distribution. Model simulation showed dosing of fentanyl in obese children based on TBW resulted in significantly higher peak concentrations than dosing based on FFM. Based on this modeling and the known concentration-effect relationship between fentanyl and adverse effects, our results suggest that bolus dosing of fentanyl in obese children should be based on FFM rather than TBW, particularly for procedures of short...
Source: Anesthesia and Analgesia - October 6, 2023 Category: Anesthesiology Authors: Carol R Okada Thomas K Henthorn Jeannie Zuk Cristina Sempio Genie Roosevelt Amanda G Ruiz Mindy N Cohen Debnath Chatterjee Jeffrey L Galinkin Source Type: research
Population Pharmacokinetics of Single Bolus Dose Fentanyl in Obese Children
CONCLUSIONS: Our data demonstrated higher peak plasma fentanyl concentrations in obese compared to nonobese subjects. Population PK analysis found that FFM was a significant covariate for the central volume of distribution. Model simulation showed dosing of fentanyl in obese children based on TBW resulted in significantly higher peak concentrations than dosing based on FFM. Based on this modeling and the known concentration-effect relationship between fentanyl and adverse effects, our results suggest that bolus dosing of fentanyl in obese children should be based on FFM rather than TBW, particularly for procedures of short...
Source: Anesthesia and Analgesia - October 6, 2023 Category: Anesthesiology Authors: Carol R Okada Thomas K Henthorn Jeannie Zuk Cristina Sempio Genie Roosevelt Amanda G Ruiz Mindy N Cohen Debnath Chatterjee Jeffrey L Galinkin Source Type: research
Population Pharmacokinetics of Single Bolus Dose Fentanyl in Obese Children
CONCLUSIONS: Our data demonstrated higher peak plasma fentanyl concentrations in obese compared to nonobese subjects. Population PK analysis found that FFM was a significant covariate for the central volume of distribution. Model simulation showed dosing of fentanyl in obese children based on TBW resulted in significantly higher peak concentrations than dosing based on FFM. Based on this modeling and the known concentration-effect relationship between fentanyl and adverse effects, our results suggest that bolus dosing of fentanyl in obese children should be based on FFM rather than TBW, particularly for procedures of short...
Source: Anesthesia and Analgesia - October 6, 2023 Category: Anesthesiology Authors: Carol R Okada Thomas K Henthorn Jeannie Zuk Cristina Sempio Genie Roosevelt Amanda G Ruiz Mindy N Cohen Debnath Chatterjee Jeffrey L Galinkin Source Type: research
Population Pharmacokinetics of Single Bolus Dose Fentanyl in Obese Children
CONCLUSIONS: Our data demonstrated higher peak plasma fentanyl concentrations in obese compared to nonobese subjects. Population PK analysis found that FFM was a significant covariate for the central volume of distribution. Model simulation showed dosing of fentanyl in obese children based on TBW resulted in significantly higher peak concentrations than dosing based on FFM. Based on this modeling and the known concentration-effect relationship between fentanyl and adverse effects, our results suggest that bolus dosing of fentanyl in obese children should be based on FFM rather than TBW, particularly for procedures of short...
Source: Anesthesia and Analgesia - October 6, 2023 Category: Anesthesiology Authors: Carol R Okada Thomas K Henthorn Jeannie Zuk Cristina Sempio Genie Roosevelt Amanda G Ruiz Mindy N Cohen Debnath Chatterjee Jeffrey L Galinkin Source Type: research
Effects of Gabapentin on Emergence Delirium in Pediatric Tonsillectomy/Adenoidectomy Patients: A Post-Hoc Analysis
AANA J. 2023 Oct;91(5):380-384.ABSTRACTEmergence delirium (ED) is a significant source of both short- and long-term negative effects in the postoperative pediatric population, most notably following otolaryngology surgeries with an occurrence rate of 17.9%. Gabapentin, a gamma aminobutyric acid agonist, has been used for enhanced recovery in adult patients and for the purpose of decreasing ED in some pediatric patients undergoing strabismus surgery. This secondary analysis examined the effects of preoperative administration of gabapentin on the reduction of postoperative ED in pediatric patients between the ages of 3-18 un...
Source: AANA Journal - October 3, 2023 Category: Anesthesiology Authors: Emily Tuggle Margaret Gettis Ann-Marie Brown Leslie Jeter Akane Fujimoto Source Type: research
Effects of Gabapentin on Emergence Delirium in Pediatric Tonsillectomy/Adenoidectomy Patients: A Post-Hoc Analysis
AANA J. 2023 Oct;91(5):380-384.ABSTRACTEmergence delirium (ED) is a significant source of both short- and long-term negative effects in the postoperative pediatric population, most notably following otolaryngology surgeries with an occurrence rate of 17.9%. Gabapentin, a gamma aminobutyric acid agonist, has been used for enhanced recovery in adult patients and for the purpose of decreasing ED in some pediatric patients undergoing strabismus surgery. This secondary analysis examined the effects of preoperative administration of gabapentin on the reduction of postoperative ED in pediatric patients between the ages of 3-18 un...
Source: AANA Journal - October 3, 2023 Category: Anesthesiology Authors: Emily Tuggle Margaret Gettis Ann-Marie Brown Leslie Jeter Akane Fujimoto Source Type: research
