Population Pharmacokinetics of Single Bolus Dose Fentanyl in Obese Children

CONCLUSIONS: Our data demonstrated higher peak plasma fentanyl concentrations in obese compared to nonobese subjects. Population PK analysis found that FFM was a significant covariate for the central volume of distribution. Model simulation showed dosing of fentanyl in obese children based on TBW resulted in significantly higher peak concentrations than dosing based on FFM. Based on this modeling and the known concentration-effect relationship between fentanyl and adverse effects, our results suggest that bolus dosing of fentanyl in obese children should be based on FFM rather than TBW, particularly for procedures of short duration.PMID:37801572 | DOI:10.1213/ANE.0000000000006554

Source: Anesthesia and Analgesia - October 6, 2023 Category: Anesthesiology Authors: Carol R Okada Thomas K Henthorn Jeannie Zuk Cristina Sempio Genie Roosevelt Amanda G Ruiz Mindy N Cohen Debnath Chatterjee Jeffrey L Galinkin Source Type: research