Novel mTOR Inhibitors Viewed as a Safer Option by Conservative Investors
The safest sort of investment into therapeutic development is one made in a part of a field that is well established, producing a small variant of an existing drug, using the well beaten path of small molecule development, targeting a mechanism that is very well understood, and that has extensive safety data associated with it. One could argue that mTOR inhibition is the canonical example of a low risk investment in the longevity field. Like most lower-risk exercises in medical development, the potential gain for patients is modest. mTOR inhibition can produce larger gains in mouse life span than exercise, but doesn't beat...
Source: Fight Aging! - April 8, 2024 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
A young surgeon ’ s night: from calm to chaos
When you are a young academic general surgeon, even the nights are sometimes good. A good on-call night unfolds something like this. You might have spent the day working in the operating room or in the clinic seeing patients. Your on-call typically begins at 5 p.m., although occasionally, a colleague may ask to sign out
Read more…
A young surgeon’s night: from calm to chaos originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 7, 2024 Category: General Medicine Authors: Carol Scott-Conner, MD, PhD Tags: Physician Surgery Source Type: blogs
More on Freeze Peach
This is a topic I address from time to time, but it seems a new post is needed now because of various nonsense that ' s going on. First, let me make one thing perfectly clear, as a man we would all like to forget used to say: free speech and academic freedom are not the same. Legally, the only meaning of Free Speech ™ is the First Amendment, as interpreted by the courts. Originally it applied only to the federal government, but the 14th Amendment extended the protections of the Bill of Rights to the States, so it now applies to all government entities within the United States, and that includes your small tow n Board of ...
Source: Stayin' Alive - April 4, 2024 Category: American Health Source Type: blogs
Will Medical Facial Recognition Technology (mFRT) Reawaken Eugenics?
By MIKE MAGEE
How comfortable is the FDA and Medical Ethics community with a new super-charged medical Facial Recognition Technology (mFRT) that claims it can “identify the early stages of autism in infants as young as 12 months?” That test already has a name -the RightEye GeoPref Autism Test. Its’ UC San Diego designer says it was 86% accurate in testing 400 infants and toddlers.
Or how about Face2Gene which claims its’ mFRT tool already has linked half of the known human genetic syndromes to “facial patterns?”
Or how about employers using mFRT facial and speech patterns to identify employees likely t...
Source: The Health Care Blog - April 4, 2024 Category: Consumer Health News Authors: matthew holt Tags: Uncategorized Source Type: blogs
Interview with Stefany Shaheen: Revolutionizing diabetes care through cell therapies
I had the extraordinary opportunity to chat with Stefany Shaheen, the Chief Strategy Officer of Advanced Regenerative Manufacturing Institute (ARMI) and BioFab USA, about the transformative potential of cell therapies for individuals living with diabetes. Stefany shared her remarkable journey, insights on cell therapies’ current status, approval challenges, and how the diabetes community can contribute to advancing research in this field.
A few months before this discussion with Stefany, I had the opportunity to hear Dean Kamen speak at the recent ...
Source: Scott's Diabetes Blog - April 1, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, April 1st 2024
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression can promote increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes.
« Back to Top
A Skeptical View of the Role of Nuclear DNA Damage in Aging
https://www.fightaging.org/archives/2024/03/a-skeptical-view-of-the-role-of-nuclear-dna-damage-in-aging/
It is evident and settled that stochastic nuclear DNA damag...
Source: Fight Aging! - March 31, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Long and Tortured History of Alpha-Synuclein and Parkinson ’s Disease
This study tracks the decades-long journey to harness alpha-synuclein as a treatment for Parkinson’s disease. Steven Zecola an activist who tracks Parkinson’s research and was on THCB last month discussing it, offers three key changes needed to overcome the underlying challenges.
A Quick Start for Alpha-Synuclein R&D
In the mid-1990’s, Parkinson’s patient advocacy groups had become impatient by the absence of any major therapeutic advances in the 25 years since L-dopa had been approved for Parkinson’s disease (PD).
The Director of National Institute of Neurological Disorders and Stroke (NINDS) se...
Source: The Health Care Blog - March 29, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Medical Practice Parkinson's Disease Steven Zecola Source Type: blogs
How AI can save lives by simplifying communication
Artificial intelligence is here. While the hype is new, it has existed longer than most think. With a history rooted in the mid-20th century, technologies like natural language processing (NLP) and machine learning (ML) spent decades in an academic chrysalis before emerging to revolutionize our daily lives. Both were introduced in the 1950s and 1960s
Read more…
How AI can save lives by simplifying communication originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 29, 2024 Category: General Medicine Authors: Carlo Mahfouz Tags: Tech Health IT Source Type: blogs
Investigating the Primary Cilium: Q & A With Xuecai Ge
Credit: Courtesy of Dr. Xuecai Ge.
The brain is a large and complex organ, but some very small structures guide its development. Xuecai Ge, Ph.D., an associate professor of molecular and cell biology at the University of California, Merced (UC Merced), has devoted her career to understanding one of these structures called the primary cilium. In an interview, Dr. Ge shared how her childhood experience inspired her to study science and what makes the primary cilium fascinating.
Q: How did you first become interested in science?
A: When I was a little kid, my mom was a primary care doctor, and I saw her treat patients...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 27, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Cellular Processes Profiles Source Type: blogs
Predicting the Order of Arrival of the First Rejuvenation Therapies
It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven in principle but not concretely. The world progresses but my biases remain much the same: the first rejuvenation therapies to work well enough to merit the name will be based on the SENS vision, that aging is at root caused by a few classes of accumulated cell and tissue damage, and biotechnologies that either repa...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Confident Sign That Your IQ Is High
This bold and confident sign is linked to higher academic achievement. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 21, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Intelligence Source Type: blogs
Physician burnout: a surgeon ’ s story of exhaustion, recovery, and systemic change
An excerpt from Safeguarding Physician Wellbeing. There are numerous books written by physicians of various specialties, primary care, and subspecialists, on the topic of physician burnout. Most physician authors, like me, have been inspired to write a book due to personal experience with a high degree of burnout, and/or have had academic interests and research
Read more…
Physician burnout: a surgeon’s story of exhaustion, recovery, and systemic change originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 20, 2024 Category: General Medicine Authors: Julie Wei, MD Tags: Physician Otolaryngology Source Type: blogs
Research Byte: Stability and Change in Academic Achievement Goals: A Meta-Analysis of Longitudinal Studies
Stability and Change in Academic Achievement Goals: A Meta-Analysis of Longitudinal Studies Vsevolod Scherrer, Maria Jalynskij, Andrew J. Elliot, Jasmin L. Becker, and Franzis PreckelAbstract Stability and change in students ' achievement goals (AGs) are of great relevance for educational research and practice. In two separate meta-analyses, we investigated the rank-order stability (93 studies, 569 effect sizes, 54,736 students), as well as the mean-level change (157 studies, 1,170 effect sizes, 81,464 students) in AGs throughout students ' academic careers (K-12 to university). We found that the average rank-order stabili...
Source: Intelligent Insights on Intelligence Theories and Tests (aka IQ's Corner) - March 19, 2024 Category: Neuroscience Source Type: blogs
Research Byte: Predicting Achievement From WISC-V Composites: Do Cognitive-Achievement Relations Vary Based on General Intelligence?
Predicting Achievement From WISC-V Composites: Do Cognitive-Achievement Relations Vary Based on General Intelligence? Jacqueline M. Caemmerer, Stephanie Ruth Young, Danika Maddocks, Natalie R. Charamut,and Eunice Blemahdoo,Abstract In order to make appropriate educational recommendations, psychologists must understand how cognitive test scores influence specific academic outcomes for students of different ability levels. We used data from the WISC-V and WIAT-III (N = 181) to examine which WISC-V Index scores predicted children ' s specific and broad academic skills and if cognitive-achievement relations varied by gene...
Source: Intelligent Insights on Intelligence Theories and Tests (aka IQ's Corner) - March 19, 2024 Category: Neuroscience Source Type: blogs
An anxious approach to a benign arrhythmia in Holter recording
A 32-year-old high-profile businessman was advised Holter monitoring for a few ectopic beats during routine screening ECG. The 72-hour extended Holter monitoring picked up a single short pause with a blocked P wave and reported as doubtful Mobitz type 2 AV block.
The cardiologist in-charge, told the patient that findings are significant, and he would need further investigation. He was referred to their associate center for an EP study. After hearing about the procedure ,the patient was freighted about inserting multiple catheters inside his heart.
This was the time he consulted me with Holter report. It was i...
Source: Dr.S.Venkatesan MD - March 19, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized 2:1 av block a pilot with av block approach to av block in holter asymptomatic mobitz type 2 block ep study esc pacemaker guideline europace heart rhythm society holter monitoring hv interval mobitz type 2 av block we Source Type: blogs
