Continued Declining Prevalence of Screening Detected Abdominal Aortic Aneurysms in 65 Year Old Swedish Men
Randomised trials conducted in the 1990s convincingly demonstrated the effectiveness of ultrasound screening for abdominal aortic aneurysm (AAA) in men.1 This formed the basis for the introduction of population screening targeting AAA among 65 year old men in Sweden in 2006 and the UK in 2008, and other countries subsequently followed. In the Swedish screening programme, a total prevalence of 2.2% (1.7% screening detected and 0.5% already known AAAs) was initially reported,2 significantly lower than the 4 – 7% previously found in trials. (Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - April 15, 2024 Category: Surgery Authors: Anders Wanhainen, Knut Thorbj ørnsen, Sven-Erik Persson, Kevin Mani, Sverker Svensjö Tags: Research Letter Source Type: research
Neutrophil Extracellular Traps in Cardiovascular and Aortic Disease: A Narrative Review on Molecular Mechanisms and Therapeutic Targeting
Int J Mol Sci. 2024 Apr 3;25(7):3983. doi: 10.3390/ijms25073983.ABSTRACTNeutrophil extracellular traps (NETs), composed of DNA, histones, and antimicrobial proteins, are released by neutrophils in response to pathogens but are also recognized for their involvement in a range of pathological processes, including autoimmune diseases, cancer, and cardiovascular diseases. This review explores the intricate roles of NETs in different cardiovascular conditions such as thrombosis, atherosclerosis, myocardial infarction, COVID-19, and particularly in the pathogenesis of abdominal aortic aneurysms. We elucidate the mechanisms under...
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Nahla Ibrahim Wolf Eilenberg Christoph Neumayer Christine Brostjan Source Type: research
Neutrophil Extracellular Traps in Cardiovascular and Aortic Disease: A Narrative Review on Molecular Mechanisms and Therapeutic Targeting
Int J Mol Sci. 2024 Apr 3;25(7):3983. doi: 10.3390/ijms25073983.ABSTRACTNeutrophil extracellular traps (NETs), composed of DNA, histones, and antimicrobial proteins, are released by neutrophils in response to pathogens but are also recognized for their involvement in a range of pathological processes, including autoimmune diseases, cancer, and cardiovascular diseases. This review explores the intricate roles of NETs in different cardiovascular conditions such as thrombosis, atherosclerosis, myocardial infarction, COVID-19, and particularly in the pathogenesis of abdominal aortic aneurysms. We elucidate the mechanisms under...
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Nahla Ibrahim Wolf Eilenberg Christoph Neumayer Christine Brostjan Source Type: research
SHP2 knockout promotes formation of abdominal aortic aneurysm by activating ERK1/2 signal pathway in mice
Asian J Surg. 2024 Apr 12:S1015-9584(24)00633-X. doi: 10.1016/j.asjsur.2024.04.001. Online ahead of print.NO ABSTRACTPMID:38614846 | DOI:10.1016/j.asjsur.2024.04.001 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 13, 2024 Category: Surgery Authors: Jian Huang Jiawei Zhuang Jiamao Wang Zhonggui Shan Source Type: research
Abdominal aortic aneurysm: epidemiology, screening, and work-up for repair
Abdominal aortic aneurysm (AAA) is a dilatation greater than 3 cm of the abdominal aorta inferior to the aortic hiatus. In the UK, population screening for AAA is offered to men in the year of their 65th birthday. Men with small AAAs (3.0–5.4 cm) are entered into an ultrasound surveillance program and have their cardiovascular risk factors managed aggress ively. An aortic aneurysm that is either symptomatic or has a diameter ≥5.5 cm should be considered for repair to prevent rupture. Repair can be undertaken using either an open surgical or endovascular approach; the decision when to repair an AAA, an by what meth...
Source: Surgery (Medicine Publishing) - April 13, 2024 Category: Surgery Authors: Emily Salt, Matthew Bown Tags: Vascular – i Source Type: research
Can HALP score predict post-contrast acute kidney injury and 6-year mortality in patients undergoing endovascular abdominal aneurysm repair?
CONCLUSIONS: The HALP score, which can be calculated with a simple formula, can be used to predict PC-AKI and medium-long-term mortality in EVAR patients.PMID:38607832 | DOI:10.1177/17085381241246905 (Source: Vascular)
Source: Vascular - April 12, 2024 Category: Surgery Authors: Ahmet Özderya Sinan Şahin Tolga Ko şmaz Mehmet Ali Maz Murat G ökhan Yerlikaya Ali R ıza Akyüz Muhammet Ra şit Sayın Hakan Erkan Source Type: research
Mid-term results of "off-label" use of the Endurant stentgraft in patients with infrarenal abdominal aortic aneurysms
CONCLUSION: In this study, real-life experience with the Endurant II and IIS stentgraft is described. Non-adherence with instructions for use was associated with a higher risk of endoleak type IA (p = .06). In the early postoperative period, there were more patients with limb occlusion; this finding was not observed anymore at the end of the follow-up period.PMID:38606774 | DOI:10.1177/17085381241247265 (Source: Vascular)
Source: Vascular - April 12, 2024 Category: Surgery Authors: Denise Michelle Danielle Özdemir-van Brunschot David Holzhey Spiridon Botsios Source Type: research
Resolvin D2 prevents vascular remodeling, hypercontractility and endothelial dysfunction in obese hypertensive mice through modulation of vascular and proinflammatory factors
Biomed Pharmacother. 2024 Apr 11;174:116564. doi: 10.1016/j.biopha.2024.116564. Online ahead of print.ABSTRACTDuring resolution of inflammation, specialized proresolving mediators (SPMs), including resolvins, are produced to restore tissue homeostasis. We hypothesized that there might be a dysregulation of SPMs pathways in pathological vascular remodeling and that resolvin D2 (RvD2) might prevent vascular remodeling and contractile and endothelial dysfunction in a model of obesity and hypertension. In aortic samples of patients with or without abdominal aortic aneurysms (AAA), we evaluated gene expression of enzymes involv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2024 Category: Drugs & Pharmacology Authors: Raquel Rodrigues-Diez Constanza Ballesteros-Martinez Rosa Mar ía Moreno-Carriles Francisco Nistal Luc ía S Díaz Del Campo Victoria Cachofeiro Jesmond Dalli Ana B Garc ía-Redondo Juan M Redondo Mercedes Salaices Ana M Briones Source Type: research
Can HALP score predict post-contrast acute kidney injury and 6-year mortality in patients undergoing endovascular abdominal aneurysm repair?
CONCLUSIONS: The HALP score, which can be calculated with a simple formula, can be used to predict PC-AKI and medium-long-term mortality in EVAR patients.PMID:38607832 | DOI:10.1177/17085381241246905 (Source: Vascular)
Source: Vascular - April 12, 2024 Category: Surgery Authors: Ahmet Özderya Sinan Şahin Tolga Ko şmaz Mehmet Ali Maz Murat G ökhan Yerlikaya Ali R ıza Akyüz Muhammet Ra şit Sayın Hakan Erkan Source Type: research
Mid-term results of "off-label" use of the Endurant stentgraft in patients with infrarenal abdominal aortic aneurysms
CONCLUSION: In this study, real-life experience with the Endurant II and IIS stentgraft is described. Non-adherence with instructions for use was associated with a higher risk of endoleak type IA (p = .06). In the early postoperative period, there were more patients with limb occlusion; this finding was not observed anymore at the end of the follow-up period.PMID:38606774 | DOI:10.1177/17085381241247265 (Source: Vascular)
Source: Vascular - April 12, 2024 Category: Surgery Authors: Denise Michelle Danielle Özdemir-van Brunschot David Holzhey Spiridon Botsios Source Type: research
Can HALP score predict post-contrast acute kidney injury and 6-year mortality in patients undergoing endovascular abdominal aneurysm repair?
CONCLUSIONS: The HALP score, which can be calculated with a simple formula, can be used to predict PC-AKI and medium-long-term mortality in EVAR patients.PMID:38607832 | DOI:10.1177/17085381241246905 (Source: Vascular)
Source: Vascular - April 12, 2024 Category: Surgery Authors: Ahmet Özderya Sinan Şahin Tolga Ko şmaz Mehmet Ali Maz Murat G ökhan Yerlikaya Ali R ıza Akyüz Muhammet Ra şit Sayın Hakan Erkan Source Type: research
Mid-term results of "off-label" use of the Endurant stentgraft in patients with infrarenal abdominal aortic aneurysms
CONCLUSION: In this study, real-life experience with the Endurant II and IIS stentgraft is described. Non-adherence with instructions for use was associated with a higher risk of endoleak type IA (p = .06). In the early postoperative period, there were more patients with limb occlusion; this finding was not observed anymore at the end of the follow-up period.PMID:38606774 | DOI:10.1177/17085381241247265 (Source: Vascular)
Source: Vascular - April 12, 2024 Category: Surgery Authors: Denise Michelle Danielle Özdemir-van Brunschot David Holzhey Spiridon Botsios Source Type: research
Resolvin D2 prevents vascular remodeling, hypercontractility and endothelial dysfunction in obese hypertensive mice through modulation of vascular and proinflammatory factors
Biomed Pharmacother. 2024 Apr 11;174:116564. doi: 10.1016/j.biopha.2024.116564. Online ahead of print.ABSTRACTDuring resolution of inflammation, specialized proresolving mediators (SPMs), including resolvins, are produced to restore tissue homeostasis. We hypothesized that there might be a dysregulation of SPMs pathways in pathological vascular remodeling and that resolvin D2 (RvD2) might prevent vascular remodeling and contractile and endothelial dysfunction in a model of obesity and hypertension. In aortic samples of patients with or without abdominal aortic aneurysms (AAA), we evaluated gene expression of enzymes involv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2024 Category: Drugs & Pharmacology Authors: Raquel Rodrigues-Diez Constanza Ballesteros-Martinez Rosa Mar ía Moreno-Carriles Francisco Nistal Luc ía S Díaz Del Campo Victoria Cachofeiro Jesmond Dalli Ana B Garc ía-Redondo Juan M Redondo Mercedes Salaices Ana M Briones Source Type: research
Can HALP score predict post-contrast acute kidney injury and 6-year mortality in patients undergoing endovascular abdominal aneurysm repair?
CONCLUSIONS: The HALP score, which can be calculated with a simple formula, can be used to predict PC-AKI and medium-long-term mortality in EVAR patients.PMID:38607832 | DOI:10.1177/17085381241246905 (Source: Vascular)
Source: Vascular - April 12, 2024 Category: Surgery Authors: Ahmet Özderya Sinan Şahin Tolga Ko şmaz Mehmet Ali Maz Murat G ökhan Yerlikaya Ali R ıza Akyüz Muhammet Ra şit Sayın Hakan Erkan Source Type: research
Mid-term results of "off-label" use of the Endurant stentgraft in patients with infrarenal abdominal aortic aneurysms
CONCLUSION: In this study, real-life experience with the Endurant II and IIS stentgraft is described. Non-adherence with instructions for use was associated with a higher risk of endoleak type IA (p = .06). In the early postoperative period, there were more patients with limb occlusion; this finding was not observed anymore at the end of the follow-up period.PMID:38606774 | DOI:10.1177/17085381241247265 (Source: Vascular)
Source: Vascular - April 12, 2024 Category: Surgery Authors: Denise Michelle Danielle Özdemir-van Brunschot David Holzhey Spiridon Botsios Source Type: research
