COVID-19-Associated Coagulopathy: Role of Vitamins D and K

Curr Pharm Biotechnol. 2022 May 27. doi: 10.2174/1389201023666220527110455. Online ahead of print.ABSTRACTRecent reports show coagulopathy as a potential complication and poorer outcome of coronavirus disease 2019 (COVID-19), especially in those with comorbid conditions such as diabetes and hypertension as thrombosis could result in stroke and heart attacks. Indeed, cardiovascular complications in COVID-19 accounts for 40% of mortality. Although there is no standard treatment protocol or guidelines for COVID-19, it is a common practice to use anti-inflammatory corticosteroids and anti-coagulants, especially for severe COVID-19 patients. It has also been confirmed that deficiencies in vitamin D and/or vitamin K can exacerbate premorbid cardiovascular and diabetes conditions associated with COVID-19, at least partially due to higher incidence of coagulopathy. Here, we discuss the roles of vitamins D and K and their roles in COVID-19-related coagulopathy. Moreover, suggestion for proper supplementations of these vitamins in countering COVID-19 is provided.PMID:35638271 | DOI:10.2174/1389201023666220527110455
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Source Type: research