Aetiology, secondary prevention strategies and outcomes of ischaemic stroke despite oral anticoagulant therapy in patients with atrial fibrillation

Conclusions Stroke despite anticoagulation comprises heterogeneous aetiologies and cardioembolism despite sufficient anticoagulation is most common. While DOAC were associated with better outcomes than VKA, adding antiplatelets was linked to worse outcomes in these high-risk patients. Our findings indicate that individualised and novel preventive strategies beyond the currently available anticoagulants are needed. Trial registration number ISRCTN48292829.

http://jnnp.bmj.com/cgi/content/short/93/6/588?rss=1

Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Polymeris, A. A., Meinel, T. R., Oehler, H., Hölscher, K., Zietz, A., Scheitz, J. F., Nolte, C. H., Stretz, C., Yaghi, S., Stoll, S., Wang, R., Häusler, K. G., Hellwig, S., Klammer, M. G., Litmeier, S., Leon Guerrero, C. R., Moeini-Naghani Tags: Open access Cerebrovascular disease Source Type: research