Predictors of cochleovestibular dysfunction in children with congenital cytomegalovirus infection

Conclusion: Besides the symptomatic status of the CMV infection at birth, we found that antenatal imaging brain damage and early infection (mainly during the first trimester) constitute the two best independent predictive factors of inner ear involvement in congenitally CMV-infected children.What is Known:• Congenital cytomegalovirus infection is the leading infectious cause of neurological disabilities and sensorineural hearing loss in children  and responsible of vestibular disorders, which are probably underestimated.• No articles have yet defined the predictive factors of the entire inner ear impairment (vestibule and cochlea).What is New:• The timing of the infection during pregnancy (first and second trimester, ORa=4.47) and antenatal imaging lesions (ORa=8.02) are independently predictive (in a multivariate analysis) of inner ear involvement.• The symptomatic status at birth is a poor predictor of inner ear impairment.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research