Thromboelastography/Platelet Mapping® and Aspirin: Is There Evidence of a Meaningful Dose-Response Relationship in Children Supported With the Berlin Heart EXCOR Ventricular Assist Device?

Thromboelastography with Platelet Mapping® (TEG/PM) is widely used to adjust the dose of Aspirin (ASA) for children supported with the Berlin Heart EXCOR Pediatric Ventricular Assist Device (VAD). The use of TEG/PM is controversial in part because stroke remains a common occurrence and TEG/PM has never been validated for this purpose. We sought to determine whether there is a meaningful correlation between the dose of ASA and the TEG/PM ‘percent arachadonic acid (%AA) inhibition’ value in children supported with the EXCOR.

Source: The Journal of Heart and Lung Transplantation - April 1, 2015 Category: Transplant Surgery Authors: L.J. May, C. Lo, T.M. Tesoro, J.L. Zehnder, S. Chen, J. Lee, M. Desai, D.B. McElhinney, D.N. Rosenthal, K. Maeda, C.S. Almond Source Type: research