Partial and complete loss of myosin binding protein H-like cause cardiac conduction defects

A premature truncation of MYBPHL in humans and a loss of Mybphl in mice is associated with dilated cardiomyopathy, atrial and ventricular arrhythmias, and atrial enlargement. MYBPHL encodes myosin binding protein H-like (MyBP-HL). Prior work in mice indirectly identified Mybphl expression in the atria and in small puncta throughout the ventricle. Because of its genetic association with human and mouse cardiac conduction system disease, we evaluated the anatomical localization of MyBP-HL and the consequences of loss of MyBP-HL on conduction system function.

Source: Journal of Molecular and Cellular Cardiology - May 6, 2022 Category: Cytology Authors: David Y. Barefield, Sean Yamakawa, Ibrahim Tahtah, Jordan J. Sell, Michael Broman, Brigitte Laforest, Sloane Harris, Alejandro A. Alvarez, Kelly N. Araujo, Megan J. Puckelwartz, J. Andrew Wasserstrom, Glenn I. Fishman, Elizabeth M. McNally Source Type: research