White Matter and Alzheimer ’s Disease: A Bidirectional Mendelian Randomization Study

ConclusionsIn this bidirectional MR study, we did not observe that WM injuries were associated with a higher risk of AD. Likewise, genetically predicted AD did not result in a causal effect on white matter damage. However, our research revealed that underlying mechanisms linking AD and white matter lesions might be related to the SNPs nearAPOE regions.

http://link.springer.com/10.1007/s40120-022-00353-9

Source: Neurology and Therapy - May 3, 2022 Category: Neurology Source Type: research