The feasibility of using an autologous GM-CSF-secreting breast cancer vaccine to induce immunity in patients with stage II-III and metastatic breast cancers

CONCLUSION: We conclude that tumor cells can be harvested from patients with metastatic or stage II-III breast cancer to prepare autologous GM-CSF-secreting vaccines that induce coordinated immune responses with limited toxicity. TRIAL REGISTRATION AND DATE OF REGISTRATION: clinicaltrials.gov, NCT00317603 (April 25, 2006) and NCT00880464 (April 13, 2009).PMID:35482127 | PMC:PMC9046531 | DOI:10.1007/s10549-022-06562-y

Source: Cell Research - April 28, 2022 Category: Cytology Authors: Karen S Anderson Timothy K Erick Meixuan Chen Heather Daley Margaret Campbell Yolonda Colson Martin Mihm Labib R Zakka Marika Hopper William Barry Eric P Winer Glenn Dranoff Beth Overmoyer Source Type: research