Up next: The dawn of systems biology in HFpEF research

Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome with heterogeneous pathophysiology and presentation [1]. Despite this, on tissue and cellular level, common pathogenetic substrates have emerged as critical in the development and progression of HFpEF: e.g., systemic (meta)-inflammation, abnormal myocardial energetics, tissue fibrosis, vascular dysfunction and dysregulated signaling pathways in cardiomyocytes [2,3].
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Tags: Letter to the editor Source Type: research