Neuronal internalization of immunoglobulin G injected into the mouse brain by a novel absorption strategy to avoid unwanted interaction with immune complex using centrifugal filtration

This study is the first demonstration of neuronal redistribution of injected IgG in the mouse brain. Neuronal internaliza tion of exogenous IgG may be advantageous especially when the therapeutic targets of monoclonal IgG are intraneuronal such as neurofibrillary tangles or Lewy bodies.

http://link.springer.com/10.1007/s00418-022-02107-y

Source: Histochemistry and Cell Biology - April 25, 2022 Category: Biomedical Science Source Type: research