Precision Medicine Approach for Cardiometabolic Risk Factors in Therapeutic Apheresis
This study revealed that proteomic analysis
correlates well with routine clinical chemistry in these patients. The method is
eminently suited to discover new biomarkers and risk factors for cardiovascular
disease in these patients. Different filters achieve reduction and removal of
proatherogenic proteins in different quantities. This includes not only
apolipoproteins, C-reactive protein, fibrinogen, and plasminogen but also
proteins like complement factor B (CFAB), protein AMBP, afamin, and the low
affinity immunoglobulin gamma Fc region receptor III-A (FcγRIIIa) among
others that have been described as atherosclerosis and metabolic vascular
diseases promoting factors. We therefore conclude that future trials should be
designed to develop an individualized therapy approach for patients on LA based
on their metabolic and vascular risk profile. Furthermore, the power of such
cascade filter treatment protocols may improve the prevention of cardiometabolic
disease and its complications. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Yin, X. Takov, K. Straube, R. Voit-Bak, K. Graessler, J. Julius, U. Tselmin, S. Rodionov, R. Barbir, M. Walls, M. Theofilatos, K. Mayr, M. Bornstein, S.R. Tags: Original Article: Endocrine Care Source Type: research